ZN454.H12INVITRO.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ZN454.H12INVITRO.1.SM.B
Gene (human)	ZNF454 (GeneCards)
Gene synonyms (human)
Gene (mouse)
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	13
Consensus	vvvMYGGCGCYWn
GC content	73.64%
Information content (bits; total / per base)	11.6 / 0.892
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	8526

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (7)	0.488	0.542	0.311	0.349	0.329	0.55	0.654	1.482	7.201	11.824

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.896	0.897	0.818	0.827	0.779	0.787
Overall, 2 experiments	best	0.999	0.999	0.997	0.996	0.985	0.981
Methyl HT-SELEX, 1 experiments	median	0.793	0.796	0.639	0.659	0.573	0.593
Methyl HT-SELEX, 1 experiments	best	0.793	0.796	0.639	0.659	0.573	0.593
Non-Methyl HT-SELEX, 1 experiments	median	0.999	0.999	0.997	0.996	0.985	0.981
Non-Methyl HT-SELEX, 1 experiments	best	0.999	0.999	0.997	0.996	0.985	0.981

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	Unclassified {2.3.3.0} (TFClass)
TFClass ID	TFClass: 2.3.3.0.125
HGNC	HGNC:21200
MGI
EntrezGene (human)	GeneID:285676 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	ZN454_HUMAN
UniProt ID (mouse)
UniProt AC (human)	Q8N9F8 (TFClass)
UniProt AC (mouse)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	ZN454.H12INVITRO.1.SM.B.pcm
PWM	ZN454.H12INVITRO.1.SM.B.pwm
PFM	ZN454.H12INVITRO.1.SM.B.pfm
Alignment	ZN454.H12INVITRO.1.SM.B.words.tsv
Threshold to P-value map	ZN454.H12INVITRO.1.SM.B.thr
Motif in other formats
JASPAR format	ZN454.H12INVITRO.1.SM.B_jaspar_format.txt
MEME format	ZN454.H12INVITRO.1.SM.B_meme_format.meme
Transfac format	ZN454.H12INVITRO.1.SM.B_transfac_format.txt
Homer format	ZN454.H12INVITRO.1.SM.B_homer_format_0.001.txt ZN454.H12INVITRO.1.SM.B_homer_format_0.0005.txt ZN454.H12INVITRO.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1924.5	2118.5	3347.5	1135.5
02	1304.25	4749.25	1570.25	902.25
03	1077.0	2508.0	4151.0	790.0
04	1782.0	5431.0	809.0	504.0
05	956.0	4959.0	101.0	2510.0
06	280.0	581.0	7400.0	265.0
07	344.0	61.0	7892.0	229.0
08	0.0	8525.0	0.0	1.0
09	78.0	78.0	8370.0	0.0
10	41.0	8133.0	0.0	352.0
11	132.0	5390.0	155.0	2849.0
12	5242.25	1154.25	300.25	1829.25
13	2865.25	2417.25	1422.25	1821.25

PFM

	A	C	G	T
01	0.226	0.248	0.393	0.133
02	0.153	0.557	0.184	0.106
03	0.126	0.294	0.487	0.093
04	0.209	0.637	0.095	0.059
05	0.112	0.582	0.012	0.294
06	0.033	0.068	0.868	0.031
07	0.04	0.007	0.926	0.027
08	0.0	1.0	0.0	0.0
09	0.009	0.009	0.982	0.0
10	0.005	0.954	0.0	0.041
11	0.015	0.632	0.018	0.334
12	0.615	0.135	0.035	0.215
13	0.336	0.284	0.167	0.214

PWM

	A	C	G	T
01	-0.102	-0.006	0.451	-0.629
02	-0.491	0.801	-0.305	-0.858
03	-0.682	0.163	0.666	-0.991
04	-0.179	0.935	-0.967	-1.439
05	-0.801	0.844	-3.028	0.163
06	-2.023	-1.297	1.244	-2.077
07	-1.818	-3.518	1.308	-2.222
08	-6.849	1.385	-6.849	-6.483
09	-3.28	-3.28	1.367	-6.849
10	-3.898	1.338	-6.849	-1.796
11	-2.766	0.927	-2.608	0.29
12	0.899	-0.612	-1.954	-0.153
13	0.296	0.126	-0.404	-0.157

Standard thresholds

P-value	Threshold
0.001	4.23031
0.0005	5.27221
0.0001	7.34197