ZN454.H12CORE.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ZN454.H12CORE.1.SM.B
Gene (human)	ZNF454 (GeneCards)
Gene synonyms (human)
Gene (mouse)
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	14
Consensus	vvSSMYGGCGCCWn
GC content	76.43%
Information content (bits; total / per base)	13.803 / 0.986
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	2411

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (7)	0.5	0.575	0.319	0.367	0.343	0.62	0.755	1.771	12.076	14.149

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.893	0.895	0.813	0.824	0.772	0.783
Overall, 2 experiments	best	1.0	1.0	0.997	0.996	0.983	0.979
Methyl HT-SELEX, 1 experiments	median	0.787	0.791	0.63	0.653	0.561	0.587
Methyl HT-SELEX, 1 experiments	best	0.787	0.791	0.63	0.653	0.561	0.587
Non-Methyl HT-SELEX, 1 experiments	median	1.0	1.0	0.997	0.996	0.983	0.979
Non-Methyl HT-SELEX, 1 experiments	best	1.0	1.0	0.997	0.996	0.983	0.979

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	Unclassified {2.3.3.0} (TFClass)
TFClass ID	TFClass: 2.3.3.0.125
HGNC	HGNC:21200
MGI
EntrezGene (human)	GeneID:285676 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	ZN454_HUMAN
UniProt ID (mouse)
UniProt AC (human)	Q8N9F8 (TFClass)
UniProt AC (mouse)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	ZN454.H12CORE.1.SM.B.pcm
PWM	ZN454.H12CORE.1.SM.B.pwm
PFM	ZN454.H12CORE.1.SM.B.pfm
Alignment	ZN454.H12CORE.1.SM.B.words.tsv
Threshold to P-value map	ZN454.H12CORE.1.SM.B.thr
Motif in other formats
JASPAR format	ZN454.H12CORE.1.SM.B_jaspar_format.txt
MEME format	ZN454.H12CORE.1.SM.B_meme_format.meme
Transfac format	ZN454.H12CORE.1.SM.B_transfac_format.txt
Homer format	ZN454.H12CORE.1.SM.B_homer_format_0.001.txt ZN454.H12CORE.1.SM.B_homer_format_0.0005.txt ZN454.H12CORE.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	817.0	404.0	923.0	267.0
02	534.75	460.75	1165.75	249.75
03	253.0	1539.0	397.0	222.0
04	206.0	626.0	1469.0	110.0
05	423.0	1736.0	172.0	80.0
06	126.0	1590.0	22.0	673.0
07	54.0	65.0	2275.0	17.0
08	26.0	16.0	2352.0	17.0
09	2.0	2409.0	0.0	0.0
10	9.0	6.0	2396.0	0.0
11	2.0	2392.0	1.0	16.0
12	38.0	1806.0	22.0	545.0
13	1379.75	344.75	92.75	593.75
14	756.0	635.0	480.0	540.0

PFM

	A	C	G	T
01	0.339	0.168	0.383	0.111
02	0.222	0.191	0.484	0.104
03	0.105	0.638	0.165	0.092
04	0.085	0.26	0.609	0.046
05	0.175	0.72	0.071	0.033
06	0.052	0.659	0.009	0.279
07	0.022	0.027	0.944	0.007
08	0.011	0.007	0.976	0.007
09	0.001	0.999	0.0	0.0
10	0.004	0.002	0.994	0.0
11	0.001	0.992	0.0	0.007
12	0.016	0.749	0.009	0.226
13	0.572	0.143	0.038	0.246
14	0.314	0.263	0.199	0.224

PWM

	A	C	G	T
01	0.303	-0.399	0.425	-0.81
02	-0.119	-0.268	0.658	-0.877
03	-0.864	0.935	-0.416	-0.993
04	-1.067	0.038	0.889	-1.687
05	-0.353	1.056	-1.246	-1.999
06	-1.553	0.968	-3.229	0.11
07	-2.38	-2.201	1.326	-3.463
08	-3.074	-3.517	1.359	-3.463
09	-5.032	1.383	-5.738	-5.738
10	-4.012	-4.332	1.378	-5.738
11	-5.032	1.376	-5.324	-3.517
12	-2.717	1.095	-3.229	-0.1
13	0.826	-0.556	-1.854	-0.015
14	0.226	0.052	-0.227	-0.11

Standard thresholds

P-value	Threshold
0.001	3.05576
0.0005	4.31631
0.0001	6.91756