ZN449.H12RSNP.1.S.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ZN449.H12RSNP.1.S.C
Gene (human)	ZNF449 (GeneCards)
Gene synonyms (human)	ZSCAN19
Gene (mouse)
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	C

Motif length	18
Consensus	dddRGKWGGKMGbKddvb
GC content	64.91%
Information content (bits; total / per base)	11.171 / 0.621
Data sources	HT-SELEX
Aligned words	1825

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (12)	0.633	0.659	0.424	0.449	0.685	0.727	1.954	2.206	44.584	72.469

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.686	0.625	0.643	0.598	0.599	0.573
Non-Methyl HT-SELEX, 1 experiments	best	0.686	0.625	0.643	0.598	0.599	0.573

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	4.716	1.961	0.088	0.047

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	Unclassified {2.3.3.0} (TFClass)
TFClass ID	TFClass: 2.3.3.0.41
HGNC	HGNC:21039
MGI
EntrezGene (human)	GeneID:203523 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	ZN449_HUMAN
UniProt ID (mouse)
UniProt AC (human)	Q6P9G9 (TFClass)
UniProt AC (mouse)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	ZN449.H12RSNP.1.S.C.pcm
PWM	ZN449.H12RSNP.1.S.C.pwm
PFM	ZN449.H12RSNP.1.S.C.pfm
Alignment	ZN449.H12RSNP.1.S.C.words.tsv
Threshold to P-value map	ZN449.H12RSNP.1.S.C.thr
Motif in other formats
JASPAR format	ZN449.H12RSNP.1.S.C_jaspar_format.txt
MEME format	ZN449.H12RSNP.1.S.C_meme_format.meme
Transfac format	ZN449.H12RSNP.1.S.C_transfac_format.txt
Homer format	ZN449.H12RSNP.1.S.C_homer_format_0.001.txt ZN449.H12RSNP.1.S.C_homer_format_0.0005.txt ZN449.H12RSNP.1.S.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	335.0	318.0	827.0	345.0
02	564.75	183.75	746.75	329.75
03	729.0	146.0	505.0	445.0
04	221.0	162.0	1284.0	158.0
05	28.0	243.0	1460.0	94.0
06	174.0	9.0	689.0	953.0
07	500.0	2.0	77.0	1246.0
08	5.0	3.0	1814.0	3.0
09	4.0	334.0	1471.0	16.0
10	67.0	9.0	1202.0	547.0
11	387.0	1218.0	186.0	34.0
12	293.0	3.0	1467.0	62.0
13	192.0	669.0	556.0	408.0
14	191.0	51.0	1359.0	224.0
15	599.0	166.0	680.0	380.0
16	305.0	284.0	820.0	416.0
17	318.0	294.0	947.0	266.0
18	309.0	362.0	775.0	379.0

PFM

	A	C	G	T
01	0.184	0.174	0.453	0.189
02	0.309	0.101	0.409	0.181
03	0.399	0.08	0.277	0.244
04	0.121	0.089	0.704	0.087
05	0.015	0.133	0.8	0.052
06	0.095	0.005	0.378	0.522
07	0.274	0.001	0.042	0.683
08	0.003	0.002	0.994	0.002
09	0.002	0.183	0.806	0.009
10	0.037	0.005	0.659	0.3
11	0.212	0.667	0.102	0.019
12	0.161	0.002	0.804	0.034
13	0.105	0.367	0.305	0.224
14	0.105	0.028	0.745	0.123
15	0.328	0.091	0.373	0.208
16	0.167	0.156	0.449	0.228
17	0.174	0.161	0.519	0.146
18	0.169	0.198	0.425	0.208

PWM

	A	C	G	T
01	-0.307	-0.359	0.593	-0.278
02	0.213	-0.903	0.491	-0.323
03	0.467	-1.131	0.101	-0.025
04	-0.721	-1.028	1.032	-1.053
05	-2.73	-0.626	1.16	-1.564
06	-0.957	-3.74	0.411	0.734
07	0.091	-4.772	-1.759	1.002
08	-4.199	-4.543	1.377	-4.543
09	-4.356	-0.31	1.168	-3.244
10	-1.895	-3.74	0.966	0.181
11	-0.164	0.979	-0.891	-2.547
12	-0.441	-4.543	1.165	-1.97
13	-0.86	0.381	0.197	-0.111
14	-0.865	-2.159	1.089	-0.707
15	0.271	-1.004	0.398	-0.182
16	-0.401	-0.472	0.584	-0.092
17	-0.359	-0.437	0.728	-0.537
18	-0.388	-0.23	0.528	-0.185

Standard thresholds

P-value	Threshold
0.001	4.49446
0.0005	5.41051
0.0001	7.24411