ZN281.H12INVIVO.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ZN281.H12INVIVO.1.SM.B
Gene (human)	ZNF281 (GeneCards)
Gene synonyms (human)	GZP1, ZBP99
Gene (mouse)	Znf281
Gene synonyms (mouse)	Zfp281
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	26
Consensus	dddRRRGGAGGGdvRRRRRRRRdddd
GC content	70.22%
Information content (bits; total / per base)	17.958 / 0.691
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	7177

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (5)	0.737	0.751	0.557	0.585	0.807	0.827	3.338	3.51	43.602	60.244
Mouse	6 (42)	0.874	0.905	0.737	0.796	0.929	0.945	4.731	5.31	140.969	221.959

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.706	0.644	0.609	0.591	0.538	0.55
Overall, 2 experiments	best	0.714	0.652	0.616	0.597	0.542	0.554
Methyl HT-SELEX, 1 experiments	median	0.699	0.635	0.602	0.586	0.534	0.546
Methyl HT-SELEX, 1 experiments	best	0.699	0.635	0.602	0.586	0.534	0.546
Non-Methyl HT-SELEX, 1 experiments	median	0.714	0.652	0.616	0.597	0.542	0.554
Non-Methyl HT-SELEX, 1 experiments	best	0.714	0.652	0.616	0.597	0.542	0.554

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	ZNF148-like {2.3.3.13} (TFClass)
TFClass ID	TFClass: 2.3.3.13.2
HGNC	HGNC:13075
MGI	MGI:3029290
EntrezGene (human)	GeneID:23528 (SSTAR profile)
EntrezGene (mouse)	GeneID:226442 (SSTAR profile)
UniProt ID (human)	ZN281_HUMAN
UniProt ID (mouse)	ZN281_MOUSE
UniProt AC (human)	Q9Y2X9 (TFClass)
UniProt AC (mouse)	Q99LI5 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 6 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	ZN281.H12INVIVO.1.SM.B.pcm
PWM	ZN281.H12INVIVO.1.SM.B.pwm
PFM	ZN281.H12INVIVO.1.SM.B.pfm
Alignment	ZN281.H12INVIVO.1.SM.B.words.tsv
Threshold to P-value map	ZN281.H12INVIVO.1.SM.B.thr
Motif in other formats
JASPAR format	ZN281.H12INVIVO.1.SM.B_jaspar_format.txt
MEME format	ZN281.H12INVIVO.1.SM.B_meme_format.meme
Transfac format	ZN281.H12INVIVO.1.SM.B_transfac_format.txt
Homer format	ZN281.H12INVIVO.1.SM.B_homer_format_0.001.txt ZN281.H12INVIVO.1.SM.B_homer_format_0.0005.txt ZN281.H12INVIVO.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1228.0	892.0	3379.0	1678.0
02	1134.75	570.75	3690.75	1780.75
03	986.0	480.0	3711.0	2000.0
04	861.0	425.0	5128.0	763.0
05	1108.0	575.0	4543.0	951.0
06	703.0	229.0	5713.0	532.0
07	78.0	233.0	6620.0	246.0
08	678.0	91.0	6327.0	81.0
09	6548.0	26.0	0.0	603.0
10	0.0	193.0	6814.0	170.0
11	2.0	6.0	7168.0	1.0
12	217.0	334.0	6046.0	580.0
13	1721.0	657.0	3752.0	1047.0
14	1843.0	1140.0	3388.0	806.0
15	1432.0	535.0	4556.0	654.0
16	1078.0	488.0	4763.0	848.0
17	978.0	589.0	4654.0	956.0
18	1263.0	635.0	4309.0	970.0
19	1320.0	535.0	4432.0	890.0
20	1194.0	585.0	4451.0	947.0
21	1161.0	549.0	4625.0	842.0
22	1228.0	546.0	4338.0	1065.0
23	1394.0	534.0	4096.0	1153.0
24	1515.0	560.0	4075.0	1027.0
25	1513.75	600.75	4013.75	1048.75
26	1585.75	771.75	3663.75	1155.75

PFM

	A	C	G	T
01	0.171	0.124	0.471	0.234
02	0.158	0.08	0.514	0.248
03	0.137	0.067	0.517	0.279
04	0.12	0.059	0.715	0.106
05	0.154	0.08	0.633	0.133
06	0.098	0.032	0.796	0.074
07	0.011	0.032	0.922	0.034
08	0.094	0.013	0.882	0.011
09	0.912	0.004	0.0	0.084
10	0.0	0.027	0.949	0.024
11	0.0	0.001	0.999	0.0
12	0.03	0.047	0.842	0.081
13	0.24	0.092	0.523	0.146
14	0.257	0.159	0.472	0.112
15	0.2	0.075	0.635	0.091
16	0.15	0.068	0.664	0.118
17	0.136	0.082	0.648	0.133
18	0.176	0.088	0.6	0.135
19	0.184	0.075	0.618	0.124
20	0.166	0.082	0.62	0.132
21	0.162	0.076	0.644	0.117
22	0.171	0.076	0.604	0.148
23	0.194	0.074	0.571	0.161
24	0.211	0.078	0.568	0.143
25	0.211	0.084	0.559	0.146
26	0.221	0.108	0.51	0.161

PWM

	A	C	G	T
01	-0.379	-0.698	0.632	-0.067
02	-0.457	-1.143	0.721	-0.008
03	-0.598	-1.315	0.726	0.108
04	-0.733	-1.436	1.049	-0.853
05	-0.481	-1.135	0.928	-0.634
06	-0.935	-2.05	1.157	-1.213
07	-3.109	-2.033	1.305	-1.979
08	-0.971	-2.959	1.259	-3.072
09	1.294	-4.154	-6.696	-1.088
10	-6.696	-2.219	1.333	-2.345
11	-6.054	-5.387	1.384	-6.324
12	-2.104	-1.676	1.214	-1.127
13	-0.042	-1.003	0.737	-0.538
14	0.027	-0.453	0.635	-0.799
15	-0.225	-1.207	0.931	-1.007
16	-0.509	-1.299	0.976	-0.748
17	-0.606	-1.111	0.952	-0.629
18	-0.351	-1.036	0.875	-0.614
19	-0.307	-1.207	0.904	-0.7
20	-0.407	-1.118	0.908	-0.638
21	-0.435	-1.181	0.946	-0.755
22	-0.379	-1.187	0.882	-0.521
23	-0.252	-1.209	0.825	-0.442
24	-0.169	-1.162	0.82	-0.557
25	-0.17	-1.092	0.804	-0.536
26	-0.123	-0.842	0.713	-0.439

Standard thresholds

P-value	Threshold
0.001	2.06146
0.0005	3.29281
0.0001	5.86026