ZN281.H12INVITRO.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ZN281.H12INVITRO.1.SM.B
Gene (human)	ZNF281 (GeneCards)
Gene synonyms (human)	GZP1, ZBP99
Gene (mouse)	Znf281
Gene synonyms (mouse)	Zfp281
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	26
Consensus	ddddKKdKKdRdKGGAGGGndRKKdd
GC content	67.85%
Information content (bits; total / per base)	17.719 / 0.682
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	800

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (5)	0.729	0.746	0.541	0.57	0.793	0.817	3.013	3.22	36.42	48.004
Mouse	6 (42)	0.869	0.907	0.707	0.792	0.926	0.947	4.332	4.936	131.054	208.77

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.714	0.645	0.614	0.594	0.54	0.551
Overall, 2 experiments	best	0.719	0.65	0.621	0.598	0.544	0.555
Methyl HT-SELEX, 1 experiments	median	0.708	0.64	0.607	0.589	0.536	0.548
Methyl HT-SELEX, 1 experiments	best	0.708	0.64	0.607	0.589	0.536	0.548
Non-Methyl HT-SELEX, 1 experiments	median	0.719	0.65	0.621	0.598	0.544	0.555
Non-Methyl HT-SELEX, 1 experiments	best	0.719	0.65	0.621	0.598	0.544	0.555

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	ZNF148-like {2.3.3.13} (TFClass)
TFClass ID	TFClass: 2.3.3.13.2
HGNC	HGNC:13075
MGI	MGI:3029290
EntrezGene (human)	GeneID:23528 (SSTAR profile)
EntrezGene (mouse)	GeneID:226442 (SSTAR profile)
UniProt ID (human)	ZN281_HUMAN
UniProt ID (mouse)	ZN281_MOUSE
UniProt AC (human)	Q9Y2X9 (TFClass)
UniProt AC (mouse)	Q99LI5 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 6 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	ZN281.H12INVITRO.1.SM.B.pcm
PWM	ZN281.H12INVITRO.1.SM.B.pwm
PFM	ZN281.H12INVITRO.1.SM.B.pfm
Alignment	ZN281.H12INVITRO.1.SM.B.words.tsv
Threshold to P-value map	ZN281.H12INVITRO.1.SM.B.thr
Motif in other formats
JASPAR format	ZN281.H12INVITRO.1.SM.B_jaspar_format.txt
MEME format	ZN281.H12INVITRO.1.SM.B_meme_format.meme
Transfac format	ZN281.H12INVITRO.1.SM.B_transfac_format.txt
Homer format	ZN281.H12INVITRO.1.SM.B_homer_format_0.001.txt ZN281.H12INVITRO.1.SM.B_homer_format_0.0005.txt ZN281.H12INVITRO.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	126.75	105.75	363.75	203.75
02	108.0	75.0	412.0	205.0
03	107.0	89.0	405.0	199.0
04	133.0	70.0	454.0	143.0
05	108.0	79.0	492.0	121.0
06	93.0	69.0	491.0	147.0
07	120.0	81.0	440.0	159.0
08	112.0	53.0	503.0	132.0
09	106.0	48.0	497.0	149.0
10	130.0	70.0	459.0	141.0
11	140.0	37.0	550.0	73.0
12	190.0	67.0	399.0	144.0
13	77.0	21.0	587.0	115.0
14	0.0	12.0	779.0	9.0
15	11.0	7.0	782.0	0.0
16	696.0	1.0	0.0	103.0
17	0.0	0.0	791.0	9.0
18	0.0	0.0	800.0	0.0
19	35.0	25.0	700.0	40.0
20	262.0	98.0	239.0	201.0
21	202.0	70.0	392.0	136.0
22	112.0	42.0	537.0	109.0
23	97.0	62.0	469.0	172.0
24	67.0	64.0	437.0	232.0
25	110.5	89.5	360.5	239.5
26	122.5	114.5	324.5	238.5

PFM

	A	C	G	T
01	0.158	0.132	0.455	0.255
02	0.135	0.094	0.515	0.256
03	0.134	0.111	0.506	0.249
04	0.166	0.088	0.568	0.179
05	0.135	0.099	0.615	0.151
06	0.116	0.086	0.614	0.184
07	0.15	0.101	0.55	0.199
08	0.14	0.066	0.629	0.165
09	0.133	0.06	0.621	0.186
10	0.163	0.088	0.574	0.176
11	0.175	0.046	0.688	0.091
12	0.238	0.084	0.499	0.18
13	0.096	0.026	0.734	0.144
14	0.0	0.015	0.974	0.011
15	0.014	0.009	0.978	0.0
16	0.87	0.001	0.0	0.129
17	0.0	0.0	0.989	0.011
18	0.0	0.0	1.0	0.0
19	0.044	0.031	0.875	0.05
20	0.328	0.123	0.299	0.251
21	0.253	0.088	0.49	0.17
22	0.14	0.053	0.671	0.136
23	0.121	0.078	0.586	0.215
24	0.084	0.08	0.546	0.29
25	0.138	0.112	0.451	0.299
26	0.153	0.143	0.406	0.298

PWM

	A	C	G	T
01	-0.451	-0.63	0.594	0.018
02	-0.609	-0.967	0.718	0.024
03	-0.618	-0.799	0.701	-0.005
04	-0.404	-1.035	0.815	-0.332
05	-0.609	-0.916	0.895	-0.497
06	-0.756	-1.049	0.893	-0.305
07	-0.505	-0.892	0.784	-0.227
08	-0.573	-1.305	0.917	-0.411
09	-0.628	-1.401	0.905	-0.292
10	-0.426	-1.035	0.826	-0.346
11	-0.353	-1.652	1.006	-0.994
12	-0.051	-1.077	0.687	-0.325
13	-0.941	-2.186	1.071	-0.547
14	-4.793	-2.691	1.354	-2.939
15	-2.767	-3.147	1.357	-4.793
16	1.241	-4.324	-4.793	-0.656
17	-4.793	-4.793	1.369	-2.939
18	-4.793	-4.793	1.38	-4.793
19	-1.705	-2.023	1.247	-1.577
20	0.268	-0.705	0.177	0.005
21	0.01	-1.035	0.669	-0.382
22	-0.573	-1.53	0.982	-0.6
23	-0.715	-1.153	0.848	-0.149
24	-1.077	-1.122	0.777	0.147
25	-0.587	-0.794	0.585	0.179
26	-0.485	-0.552	0.481	0.175

Standard thresholds

P-value	Threshold
0.001	1.94996
0.0005	3.24051
0.0001	5.92321