ZIC5.H12CORE.1.M.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ZIC5.H12CORE.1.M.C
Gene (human)	ZIC5 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Zic5
Gene synonyms (mouse)	Opr
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	C

Motif length	17
Consensus	ndCACAGCAGGGGGTMn
GC content	67.83%
Information content (bits; total / per base)	22.461 / 1.321
Data sources	Methyl-HT-SELEX
Aligned words	9323

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	9 (61)	0.925	0.971	0.883	0.955	0.876	0.945	3.585	5.304	334.013	491.155

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.963	0.965	0.779	0.81	0.624	0.677
Overall, 2 experiments	best	1.0	1.0	0.87	0.89	0.668	0.726
Methyl HT-SELEX, 1 experiments	median	1.0	1.0	0.87	0.89	0.668	0.726
Methyl HT-SELEX, 1 experiments	best	1.0	1.0	0.87	0.89	0.668	0.726
Non-Methyl HT-SELEX, 1 experiments	median	0.926	0.93	0.689	0.73	0.581	0.628
Non-Methyl HT-SELEX, 1 experiments	best	0.926	0.93	0.689	0.73	0.581	0.628

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	GLI-lile {2.3.3.1} (TFClass)
TFClass ID	TFClass: 2.3.3.1.11
HGNC	HGNC:20322
MGI	MGI:1929518
EntrezGene (human)	GeneID:85416 (SSTAR profile)
EntrezGene (mouse)	GeneID:65100 (SSTAR profile)
UniProt ID (human)	ZIC5_HUMAN
UniProt ID (mouse)	ZIC5_MOUSE
UniProt AC (human)	Q96T25 (TFClass)
UniProt AC (mouse)	Q7TQ40 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	9 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	ZIC5.H12CORE.1.M.C.pcm
PWM	ZIC5.H12CORE.1.M.C.pwm
PFM	ZIC5.H12CORE.1.M.C.pfm
Alignment	ZIC5.H12CORE.1.M.C.words.tsv
Threshold to P-value map	ZIC5.H12CORE.1.M.C.thr
Motif in other formats
JASPAR format	ZIC5.H12CORE.1.M.C_jaspar_format.txt
MEME format	ZIC5.H12CORE.1.M.C_meme_format.meme
Transfac format	ZIC5.H12CORE.1.M.C_transfac_format.txt
Homer format	ZIC5.H12CORE.1.M.C_homer_format_0.001.txt ZIC5.H12CORE.1.M.C_homer_format_0.0005.txt ZIC5.H12CORE.1.M.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1899.25	2946.25	1850.25	2627.25
02	1684.75	409.75	3305.75	3922.75
03	1027.0	8201.0	88.0	7.0
04	7744.0	205.0	193.0	1181.0
05	4.0	9305.0	1.0	13.0
06	8837.0	407.0	49.0	30.0
07	74.0	6.0	9243.0	0.0
08	4.0	9070.0	7.0	242.0
09	6357.0	0.0	2966.0	0.0
10	1.0	0.0	9291.0	31.0
11	1.0	1.0	9321.0	0.0
12	72.0	3.0	9100.0	148.0
13	22.0	2.0	9274.0	25.0
14	27.0	3.0	8811.0	482.0
15	13.0	1259.0	703.0	7348.0
16	1973.25	5995.25	1054.25	300.25
17	1794.0	2496.0	1932.0	3101.0

PFM

	A	C	G	T
01	0.204	0.316	0.198	0.282
02	0.181	0.044	0.355	0.421
03	0.11	0.88	0.009	0.001
04	0.831	0.022	0.021	0.127
05	0.0	0.998	0.0	0.001
06	0.948	0.044	0.005	0.003
07	0.008	0.001	0.991	0.0
08	0.0	0.973	0.001	0.026
09	0.682	0.0	0.318	0.0
10	0.0	0.0	0.997	0.003
11	0.0	0.0	1.0	0.0
12	0.008	0.0	0.976	0.016
13	0.002	0.0	0.995	0.003
14	0.003	0.0	0.945	0.052
15	0.001	0.135	0.075	0.788
16	0.212	0.643	0.113	0.032
17	0.192	0.268	0.207	0.333

PWM

	A	C	G	T
01	-0.205	0.234	-0.231	0.12
02	-0.324	-1.734	0.349	0.52
03	-0.818	1.257	-3.252	-5.527
04	1.2	-2.421	-2.48	-0.679
05	-5.917	1.384	-6.566	-5.028
06	1.332	-1.741	-3.818	-4.28
07	-3.42	-5.64	1.377	-6.929
08	-5.917	1.358	-5.527	-2.257
09	1.003	-6.929	0.241	-6.929
10	-6.566	-6.929	1.382	-4.25
11	-6.566	-6.566	1.385	-6.929
12	-3.447	-6.09	1.361	-2.742
13	-4.565	-6.3	1.38	-4.449
14	-4.378	-6.09	1.329	-1.572
15	-5.028	-0.615	-1.196	1.148
16	-0.166	0.944	-0.792	-2.043
17	-0.261	0.068	-0.187	0.285

Standard thresholds

P-value	Threshold
0.001	-5.47799
0.0005	-3.38419
0.0001	1.02206