ZIC3.H12RSNP.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ZIC3.H12RSNP.0.P.B
Gene (human)	ZIC3 (GeneCards)
Gene synonyms (human)	ZNF203
Gene (mouse)	Zic3
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	14
Consensus	SnSWSCWGGddvbn
GC content	63.95%
Information content (bits; total / per base)	7.946 / 0.568
Data sources	ChIP-Seq
Aligned words	1054

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	4 (27)	0.87	0.917	0.754	0.835	0.776	0.88	2.267	3.362	88.42	258.06

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.718	0.74	0.6	0.618	0.547	0.567
Overall, 6 experiments	best	0.999	0.999	0.998	0.997	0.986	0.984
Methyl HT-SELEX, 2 experiments	median	0.81	0.822	0.773	0.783	0.753	0.761
Methyl HT-SELEX, 2 experiments	best	0.999	0.999	0.998	0.997	0.986	0.984
Non-Methyl HT-SELEX, 4 experiments	median	0.718	0.74	0.6	0.618	0.547	0.567
Non-Methyl HT-SELEX, 4 experiments	best	0.997	0.995	0.991	0.986	0.969	0.96

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.684	0.093	0.774	0.433
batch 2	0.749	0.362	0.55	0.405

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	GLI-lile {2.3.3.1} (TFClass)
TFClass ID	TFClass: 2.3.3.1.9
HGNC	HGNC:12874
MGI	MGI:106676
EntrezGene (human)	GeneID:7547 (SSTAR profile)
EntrezGene (mouse)	GeneID:22773 (SSTAR profile)
UniProt ID (human)	ZIC3_HUMAN
UniProt ID (mouse)	ZIC3_MOUSE
UniProt AC (human)	O60481 (TFClass)
UniProt AC (mouse)	Q62521 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 4 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	ZIC3.H12RSNP.0.P.B.pcm
PWM	ZIC3.H12RSNP.0.P.B.pwm
PFM	ZIC3.H12RSNP.0.P.B.pfm
Alignment	ZIC3.H12RSNP.0.P.B.words.tsv
Threshold to P-value map	ZIC3.H12RSNP.0.P.B.thr
Motif in other formats
JASPAR format	ZIC3.H12RSNP.0.P.B_jaspar_format.txt
MEME format	ZIC3.H12RSNP.0.P.B_meme_format.meme
Transfac format	ZIC3.H12RSNP.0.P.B_transfac_format.txt
Homer format	ZIC3.H12RSNP.0.P.B_homer_format_0.001.txt ZIC3.H12RSNP.0.P.B_homer_format_0.0005.txt ZIC3.H12RSNP.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	180.0	641.0	204.0	29.0
02	377.0	228.0	213.0	236.0
03	95.0	770.0	160.0	29.0
04	636.0	147.0	86.0	185.0
05	102.0	155.0	771.0	26.0
06	37.0	935.0	24.0	58.0
07	770.0	23.0	130.0	131.0
08	59.0	7.0	904.0	84.0
09	130.0	19.0	851.0	54.0
10	349.0	100.0	463.0	142.0
11	301.0	98.0	519.0	136.0
12	192.0	194.0	524.0	144.0
13	105.0	442.0	272.0	235.0
14	275.0	361.0	196.0	222.0

PFM

	A	C	G	T
01	0.171	0.608	0.194	0.028
02	0.358	0.216	0.202	0.224
03	0.09	0.731	0.152	0.028
04	0.603	0.139	0.082	0.176
05	0.097	0.147	0.731	0.025
06	0.035	0.887	0.023	0.055
07	0.731	0.022	0.123	0.124
08	0.056	0.007	0.858	0.08
09	0.123	0.018	0.807	0.051
10	0.331	0.095	0.439	0.135
11	0.286	0.093	0.492	0.129
12	0.182	0.184	0.497	0.137
13	0.1	0.419	0.258	0.223
14	0.261	0.343	0.186	0.211

PWM

	A	C	G	T
01	-0.378	0.885	-0.254	-2.155
02	0.356	-0.144	-0.211	-0.109
03	-1.009	1.068	-0.495	-2.155
04	0.877	-0.578	-1.106	-0.351
05	-0.939	-0.526	1.069	-2.258
06	-1.924	1.262	-2.333	-1.491
07	1.068	-2.372	-0.7	-0.692
08	-1.474	-3.413	1.228	-1.129
09	-0.7	-2.549	1.168	-1.56
10	0.279	-0.958	0.561	-0.613
11	0.132	-0.978	0.675	-0.655
12	-0.314	-0.304	0.684	-0.599
13	-0.91	0.515	0.032	-0.114
14	0.042	0.313	-0.294	-0.17

Standard thresholds

P-value	Threshold
0.001	4.93321
0.0005	5.61371
0.0001	7.01081