ZIC3.H12CORE.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ZIC3.H12CORE.1.S.B
Gene (human)	ZIC3 (GeneCards)
Gene synonyms (human)	ZNF203
Gene (mouse)	Zic3
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	16
Consensus	dMdCMGCGGGGGKbvn
GC content	68.24%
Information content (bits; total / per base)	13.782 / 0.861
Data sources	HT-SELEX
Aligned words	7487

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	4 (27)	0.852	0.909	0.708	0.823	0.756	0.855	2.086	2.858	77.201	261.658

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.747	0.769	0.61	0.638	0.554	0.579
Overall, 6 experiments	best	1.0	0.999	0.999	0.999	0.998	0.997
Methyl HT-SELEX, 2 experiments	median	0.81	0.823	0.777	0.786	0.766	0.77
Methyl HT-SELEX, 2 experiments	best	1.0	0.999	0.999	0.999	0.998	0.997
Non-Methyl HT-SELEX, 4 experiments	median	0.747	0.769	0.61	0.638	0.554	0.579
Non-Methyl HT-SELEX, 4 experiments	best	0.999	0.998	0.998	0.997	0.995	0.993

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.907	0.097	0.818	0.433
batch 2	0.831	0.577	0.674	0.485

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	GLI-lile {2.3.3.1} (TFClass)
TFClass ID	TFClass: 2.3.3.1.9
HGNC	HGNC:12874
MGI	MGI:106676
EntrezGene (human)	GeneID:7547 (SSTAR profile)
EntrezGene (mouse)	GeneID:22773 (SSTAR profile)
UniProt ID (human)	ZIC3_HUMAN
UniProt ID (mouse)	ZIC3_MOUSE
UniProt AC (human)	O60481 (TFClass)
UniProt AC (mouse)	Q62521 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 4 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	ZIC3.H12CORE.1.S.B.pcm
PWM	ZIC3.H12CORE.1.S.B.pwm
PFM	ZIC3.H12CORE.1.S.B.pfm
Alignment	ZIC3.H12CORE.1.S.B.words.tsv
Threshold to P-value map	ZIC3.H12CORE.1.S.B.thr
Motif in other formats
JASPAR format	ZIC3.H12CORE.1.S.B_jaspar_format.txt
MEME format	ZIC3.H12CORE.1.S.B_meme_format.meme
Transfac format	ZIC3.H12CORE.1.S.B_transfac_format.txt
Homer format	ZIC3.H12CORE.1.S.B_homer_format_0.001.txt ZIC3.H12CORE.1.S.B_homer_format_0.0005.txt ZIC3.H12CORE.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2247.0	712.0	2133.0	2395.0
02	1711.75	4750.75	609.75	414.75
03	3639.0	744.0	1994.0	1110.0
04	178.0	6806.0	197.0	306.0
05	5447.0	1056.0	453.0	531.0
06	1064.0	113.0	6271.0	39.0
07	45.0	6688.0	182.0	572.0
08	2245.0	1.0	5209.0	32.0
09	48.0	65.0	7159.0	215.0
10	104.0	64.0	7152.0	167.0
11	752.0	104.0	6083.0	548.0
12	328.0	273.0	6111.0	775.0
13	626.0	237.0	5961.0	663.0
14	446.0	1840.0	1326.0	3875.0
15	2123.75	3224.75	1069.75	1068.75
16	1921.5	1479.5	1679.5	2406.5

PFM

	A	C	G	T
01	0.3	0.095	0.285	0.32
02	0.229	0.635	0.081	0.055
03	0.486	0.099	0.266	0.148
04	0.024	0.909	0.026	0.041
05	0.728	0.141	0.061	0.071
06	0.142	0.015	0.838	0.005
07	0.006	0.893	0.024	0.076
08	0.3	0.0	0.696	0.004
09	0.006	0.009	0.956	0.029
10	0.014	0.009	0.955	0.022
11	0.1	0.014	0.812	0.073
12	0.044	0.036	0.816	0.104
13	0.084	0.032	0.796	0.089
14	0.06	0.246	0.177	0.518
15	0.284	0.431	0.143	0.143
16	0.257	0.198	0.224	0.321

PWM

	A	C	G	T
01	0.183	-0.965	0.131	0.246
02	-0.089	0.931	-1.119	-1.503
03	0.664	-0.921	0.063	-0.522
04	-2.342	1.29	-2.241	-1.805
05	1.067	-0.571	-1.415	-1.257
06	-0.564	-2.789	1.208	-3.817
07	-3.681	1.273	-2.32	-1.183
08	0.182	-6.363	1.023	-4.003
09	-3.619	-3.328	1.341	-2.155
10	-2.87	-3.343	1.34	-2.405
11	-0.91	-2.87	1.178	-1.225
12	-1.736	-1.918	1.182	-0.88
13	-1.093	-2.058	1.158	-1.036
14	-1.431	-0.017	-0.344	0.727
15	0.126	0.543	-0.559	-0.559
16	0.026	-0.235	-0.108	0.251

Standard thresholds

P-value	Threshold
0.001	3.53646
0.0005	4.60136
0.0001	6.82201