ZIC1.H12RSNP.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ZIC1.H12RSNP.0.P.B
Gene (human)	ZIC1 (GeneCards)
Gene synonyms (human)	ZIC, ZNF201
Gene (mouse)	Zic1
Gene synonyms (mouse)	Zic
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	10
Consensus	CnCWGCRGGv
GC content	74.5%
Information content (bits; total / per base)	12.501 / 1.25
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	2 (14)	0.865	0.871	0.721	0.746	0.758	0.799	2.079	2.258	103.602	115.921

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.983	0.969	0.97	0.953	0.949	0.931
Overall, 6 experiments	best	0.993	0.984	0.986	0.977	0.962	0.95
Methyl HT-SELEX, 2 experiments	median	0.989	0.978	0.98	0.968	0.954	0.938
Methyl HT-SELEX, 2 experiments	best	0.993	0.984	0.986	0.977	0.962	0.95
Non-Methyl HT-SELEX, 4 experiments	median	0.892	0.883	0.806	0.805	0.758	0.764
Non-Methyl HT-SELEX, 4 experiments	best	0.99	0.982	0.983	0.972	0.96	0.937

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.787	0.267	0.767	0.501
batch 2	0.647	0.353	0.563	0.425

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	GLI-lile {2.3.3.1} (TFClass)
TFClass ID	TFClass: 2.3.3.1.7
HGNC	HGNC:12872
MGI	MGI:106683
EntrezGene (human)	GeneID:7545 (SSTAR profile)
EntrezGene (mouse)	GeneID:22771 (SSTAR profile)
UniProt ID (human)	ZIC1_HUMAN
UniProt ID (mouse)	ZIC1_MOUSE
UniProt AC (human)	Q15915 (TFClass)
UniProt AC (mouse)	P46684 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 2 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	ZIC1.H12RSNP.0.P.B.pcm
PWM	ZIC1.H12RSNP.0.P.B.pwm
PFM	ZIC1.H12RSNP.0.P.B.pfm
Alignment	ZIC1.H12RSNP.0.P.B.words.tsv
Threshold to P-value map	ZIC1.H12RSNP.0.P.B.thr
Motif in other formats
JASPAR format	ZIC1.H12RSNP.0.P.B_jaspar_format.txt
MEME format	ZIC1.H12RSNP.0.P.B_meme_format.meme
Transfac format	ZIC1.H12RSNP.0.P.B_transfac_format.txt
Homer format	ZIC1.H12RSNP.0.P.B_homer_format_0.001.txt ZIC1.H12RSNP.0.P.B_homer_format_0.0005.txt ZIC1.H12RSNP.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	99.0	849.0	46.0	6.0
02	243.0	277.0	299.0	181.0
03	1.0	998.0	1.0	0.0
04	764.0	107.0	11.0	118.0
05	5.0	1.0	994.0	0.0
06	9.0	977.0	3.0	11.0
07	585.0	1.0	403.0	11.0
08	5.0	3.0	922.0	70.0
09	1.0	1.0	991.0	7.0
10	350.0	185.0	381.0	84.0

PFM

	A	C	G	T
01	0.099	0.849	0.046	0.006
02	0.243	0.277	0.299	0.181
03	0.001	0.998	0.001	0.0
04	0.764	0.107	0.011	0.118
05	0.005	0.001	0.994	0.0
06	0.009	0.977	0.003	0.011
07	0.585	0.001	0.403	0.011
08	0.005	0.003	0.922	0.07
09	0.001	0.001	0.991	0.007
10	0.35	0.185	0.381	0.084

PWM

	A	C	G	T
01	-0.916	1.218	-1.663	-3.484
02	-0.028	0.102	0.178	-0.32
03	-4.525	1.379	-4.525	-4.982
04	1.112	-0.84	-2.985	-0.743
05	-3.622	-4.525	1.375	-4.982
06	-3.156	1.358	-3.975	-2.985
07	0.846	-4.525	0.475	-2.985
08	-3.622	-3.975	1.3	-1.255
09	-4.525	-4.525	1.372	-3.362
10	0.335	-0.299	0.419	-1.077

Standard thresholds

P-value	Threshold
0.001	3.593295
0.0005	4.834925
0.0001	7.494685