ZIC1.H12INVIVO.2.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ZIC1.H12INVIVO.2.S.B
Gene (human)	ZIC1 (GeneCards)
Gene synonyms (human)	ZIC, ZNF201
Gene (mouse)	Zic1
Gene synonyms (mouse)	Zic
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	15
Consensus	ndMdCAGCGGGGRKb
GC content	71.71%
Information content (bits; total / per base)	16.842 / 1.123
Data sources	HT-SELEX
Aligned words	2256

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	2 (14)	0.82	0.843	0.688	0.73	0.715	0.764	1.972	2.285	76.682	89.796

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.997	0.995	0.991	0.987	0.962	0.954
Overall, 6 experiments	best	0.999	0.998	0.997	0.996	0.987	0.984
Methyl HT-SELEX, 2 experiments	median	0.998	0.997	0.995	0.992	0.98	0.975
Methyl HT-SELEX, 2 experiments	best	0.999	0.998	0.997	0.996	0.987	0.984
Non-Methyl HT-SELEX, 4 experiments	median	0.915	0.916	0.826	0.835	0.763	0.774
Non-Methyl HT-SELEX, 4 experiments	best	0.998	0.997	0.996	0.994	0.982	0.977

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.854	0.36	0.817	0.52
batch 2	0.742	0.448	0.68	0.505

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	GLI-lile {2.3.3.1} (TFClass)
TFClass ID	TFClass: 2.3.3.1.7
HGNC	HGNC:12872
MGI	MGI:106683
EntrezGene (human)	GeneID:7545 (SSTAR profile)
EntrezGene (mouse)	GeneID:22771 (SSTAR profile)
UniProt ID (human)	ZIC1_HUMAN
UniProt ID (mouse)	ZIC1_MOUSE
UniProt AC (human)	Q15915 (TFClass)
UniProt AC (mouse)	P46684 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 2 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	ZIC1.H12INVIVO.2.S.B.pcm
PWM	ZIC1.H12INVIVO.2.S.B.pwm
PFM	ZIC1.H12INVIVO.2.S.B.pfm
Alignment	ZIC1.H12INVIVO.2.S.B.words.tsv
Threshold to P-value map	ZIC1.H12INVIVO.2.S.B.thr
Motif in other formats
JASPAR format	ZIC1.H12INVIVO.2.S.B_jaspar_format.txt
MEME format	ZIC1.H12INVIVO.2.S.B_meme_format.meme
Transfac format	ZIC1.H12INVIVO.2.S.B_transfac_format.txt
Homer format	ZIC1.H12INVIVO.2.S.B_homer_format_0.001.txt ZIC1.H12INVIVO.2.S.B_homer_format_0.0005.txt ZIC1.H12INVIVO.2.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	560.75	504.75	581.75	608.75
02	481.25	130.25	938.25	706.25
03	305.0	1716.0	208.0	27.0
04	1204.0	143.0	628.0	281.0
05	7.0	2216.0	12.0	21.0
06	2103.0	52.0	7.0	94.0
07	10.0	0.0	2246.0	0.0
08	0.0	2239.0	6.0	11.0
09	248.0	0.0	2008.0	0.0
10	5.0	8.0	2235.0	8.0
11	4.0	7.0	2225.0	20.0
12	261.0	7.0	1785.0	203.0
13	407.0	77.0	1540.0	232.0
14	263.5	114.5	1610.5	267.5
15	130.0	637.0	383.0	1106.0

PFM

	A	C	G	T
01	0.249	0.224	0.258	0.27
02	0.213	0.058	0.416	0.313
03	0.135	0.761	0.092	0.012
04	0.534	0.063	0.278	0.125
05	0.003	0.982	0.005	0.009
06	0.932	0.023	0.003	0.042
07	0.004	0.0	0.996	0.0
08	0.0	0.992	0.003	0.005
09	0.11	0.0	0.89	0.0
10	0.002	0.004	0.991	0.004
11	0.002	0.003	0.986	0.009
12	0.116	0.003	0.791	0.09
13	0.18	0.034	0.683	0.103
14	0.117	0.051	0.714	0.119
15	0.058	0.282	0.17	0.49

PWM

	A	C	G	T
01	-0.006	-0.111	0.031	0.076
02	-0.158	-1.454	0.508	0.224
03	-0.612	1.11	-0.992	-2.974
04	0.757	-1.362	0.107	-0.693
05	-4.149	1.366	-3.704	-3.206
06	1.314	-2.351	-4.149	-1.775
07	-3.859	-5.681	1.379	-5.681
08	-5.681	1.376	-4.268	-3.779
09	-0.817	-5.681	1.267	-5.681
10	-4.403	-4.043	1.374	-4.043
11	-4.558	-4.149	1.37	-3.251
12	-0.767	-4.149	1.15	-1.016
13	-0.325	-1.97	1.002	-0.883
14	-0.757	-1.581	1.047	-0.742
15	-1.456	0.121	-0.385	0.672

Standard thresholds

P-value	Threshold
0.001	1.16946
0.0005	2.64136
0.0001	5.68891