ZIC1.H12INVITRO.1.M.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ZIC1.H12INVITRO.1.M.B
Gene (human)	ZIC1 (GeneCards)
Gene synonyms (human)	ZIC, ZNF201
Gene (mouse)	Zic1
Gene synonyms (mouse)	Zic
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	16
Consensus	ndMWCAGCAGGGGGYn
GC content	65.94%
Information content (bits; total / per base)	16.95 / 1.059
Data sources	Methyl-HT-SELEX
Aligned words	9998

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	2 (14)	0.835	0.854	0.691	0.72	0.703	0.745	1.941	2.033	59.777	79.432

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.998	0.997	0.996	0.994	0.984	0.98
Overall, 6 experiments	best	1.0	1.0	1.0	0.999	0.998	0.998
Methyl HT-SELEX, 2 experiments	median	1.0	0.999	0.999	0.999	0.996	0.995
Methyl HT-SELEX, 2 experiments	best	1.0	1.0	1.0	0.999	0.998	0.998
Non-Methyl HT-SELEX, 4 experiments	median	0.926	0.928	0.831	0.843	0.777	0.791
Non-Methyl HT-SELEX, 4 experiments	best	0.999	0.998	0.998	0.996	0.992	0.989

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.929	0.396	0.923	0.583
batch 2	0.8	0.527	0.787	0.582

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	GLI-lile {2.3.3.1} (TFClass)
TFClass ID	TFClass: 2.3.3.1.7
HGNC	HGNC:12872
MGI	MGI:106683
EntrezGene (human)	GeneID:7545 (SSTAR profile)
EntrezGene (mouse)	GeneID:22771 (SSTAR profile)
UniProt ID (human)	ZIC1_HUMAN
UniProt ID (mouse)	ZIC1_MOUSE
UniProt AC (human)	Q15915 (TFClass)
UniProt AC (mouse)	P46684 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 2 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	ZIC1.H12INVITRO.1.M.B.pcm
PWM	ZIC1.H12INVITRO.1.M.B.pwm
PFM	ZIC1.H12INVITRO.1.M.B.pfm
Alignment	ZIC1.H12INVITRO.1.M.B.words.tsv
Threshold to P-value map	ZIC1.H12INVITRO.1.M.B.thr
Motif in other formats
JASPAR format	ZIC1.H12INVITRO.1.M.B_jaspar_format.txt
MEME format	ZIC1.H12INVITRO.1.M.B_meme_format.meme
Transfac format	ZIC1.H12INVITRO.1.M.B_transfac_format.txt
Homer format	ZIC1.H12INVITRO.1.M.B_homer_format_0.001.txt ZIC1.H12INVITRO.1.M.B_homer_format_0.0005.txt ZIC1.H12INVITRO.1.M.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2403.0	2895.0	2224.0	2476.0
02	2140.5	807.5	3380.5	3669.5
03	2944.0	6526.0	441.0	87.0
04	7109.0	368.0	750.0	1771.0
05	70.0	9698.0	50.0	180.0
06	8104.0	1401.0	320.0	173.0
07	475.0	38.0	9475.0	10.0
08	16.0	9378.0	113.0	491.0
09	7826.0	0.0	2151.0	21.0
10	7.0	16.0	9629.0	346.0
11	21.0	41.0	9910.0	26.0
12	740.0	71.0	8518.0	669.0
13	459.0	133.0	8792.0	614.0
14	622.0	131.0	8108.0	1137.0
15	146.5	2234.5	1929.5	5687.5
16	2572.0	3463.0	2485.0	1478.0

PFM

	A	C	G	T
01	0.24	0.29	0.222	0.248
02	0.214	0.081	0.338	0.367
03	0.294	0.653	0.044	0.009
04	0.711	0.037	0.075	0.177
05	0.007	0.97	0.005	0.018
06	0.811	0.14	0.032	0.017
07	0.048	0.004	0.948	0.001
08	0.002	0.938	0.011	0.049
09	0.783	0.0	0.215	0.002
10	0.001	0.002	0.963	0.035
11	0.002	0.004	0.991	0.003
12	0.074	0.007	0.852	0.067
13	0.046	0.013	0.879	0.061
14	0.062	0.013	0.811	0.114
15	0.015	0.223	0.193	0.569
16	0.257	0.346	0.249	0.148

PWM

	A	C	G	T
01	-0.039	0.147	-0.117	-0.009
02	-0.155	-1.128	0.302	0.384
03	0.164	0.959	-1.731	-3.333
04	1.045	-1.91	-1.202	-0.344
05	-3.544	1.355	-3.868	-2.619
06	1.176	-0.578	-2.049	-2.658
07	-1.657	-4.128	1.332	-5.315
08	-4.918	1.322	-3.077	-1.624
09	1.141	-6.991	-0.15	-4.676
10	-5.594	-4.918	1.348	-1.972
11	-4.676	-4.057	1.377	-4.482
12	-1.215	-3.53	1.225	-1.316
13	-1.691	-2.917	1.257	-1.401
14	-1.388	-2.932	1.176	-0.787
15	-2.822	-0.112	-0.259	0.822
16	0.029	0.326	-0.006	-0.525

Standard thresholds

P-value	Threshold
0.001	1.51286
0.0005	2.89781
0.0001	5.77656