ZBT7A.H12RSNP.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ZBT7A.H12RSNP.1.SM.B
Gene (human)	ZBTB7A (GeneCards)
Gene synonyms (human)	FBI1, LRF, ZBTB7, ZNF857A
Gene (mouse)	Zbtb7a
Gene synonyms (mouse)	Lrf, Zbtb7
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	14
Consensus	dddvRGKGGTCGhb
GC content	68.59%
Information content (bits; total / per base)	11.855 / 0.847
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9532

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	9 (61)	0.686	0.749	0.484	0.548	0.623	0.752	1.505	2.014	39.585	87.276

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.926	0.888	0.862	0.822	0.78	0.749
Overall, 2 experiments	best	0.94	0.906	0.877	0.84	0.795	0.765
Methyl HT-SELEX, 1 experiments	median	0.912	0.87	0.847	0.803	0.765	0.733
Methyl HT-SELEX, 1 experiments	best	0.912	0.87	0.847	0.803	0.765	0.733
Non-Methyl HT-SELEX, 1 experiments	median	0.94	0.906	0.877	0.84	0.795	0.765
Non-Methyl HT-SELEX, 1 experiments	best	0.94	0.906	0.877	0.84	0.795	0.765

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	4.05	0.975	0.125	0.102

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	ZBTB7 {2.3.3.8} (TFClass)
TFClass ID	TFClass: 2.3.3.8.1
HGNC	HGNC:18078
MGI	MGI:1335091
EntrezGene (human)	GeneID:51341 (SSTAR profile)
EntrezGene (mouse)	GeneID:16969 (SSTAR profile)
UniProt ID (human)	ZBT7A_HUMAN
UniProt ID (mouse)	ZBT7A_MOUSE
UniProt AC (human)	O95365 (TFClass)
UniProt AC (mouse)	O88939 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	9 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	ZBT7A.H12RSNP.1.SM.B.pcm
PWM	ZBT7A.H12RSNP.1.SM.B.pwm
PFM	ZBT7A.H12RSNP.1.SM.B.pfm
Alignment	ZBT7A.H12RSNP.1.SM.B.words.tsv
Threshold to P-value map	ZBT7A.H12RSNP.1.SM.B.thr
Motif in other formats
JASPAR format	ZBT7A.H12RSNP.1.SM.B_jaspar_format.txt
MEME format	ZBT7A.H12RSNP.1.SM.B_meme_format.meme
Transfac format	ZBT7A.H12RSNP.1.SM.B_transfac_format.txt
Homer format	ZBT7A.H12RSNP.1.SM.B_homer_format_0.001.txt ZBT7A.H12RSNP.1.SM.B_homer_format_0.0005.txt ZBT7A.H12RSNP.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1693.0	1210.0	4607.0	2022.0
02	1826.0	1183.0	4517.0	2006.0
03	1876.0	815.0	4506.0	2335.0
04	1810.0	1970.0	3964.0	1788.0
05	1459.0	618.0	6872.0	583.0
06	863.0	79.0	8352.0	238.0
07	157.0	25.0	4680.0	4670.0
08	17.0	76.0	9424.0	15.0
09	37.0	72.0	9328.0	95.0
10	152.0	1.0	954.0	8425.0
11	151.0	8451.0	765.0	165.0
12	241.0	142.0	8609.0	540.0
13	2162.5	3906.5	563.5	2899.5
14	1762.5	1965.5	3877.5	1926.5

PFM

	A	C	G	T
01	0.178	0.127	0.483	0.212
02	0.192	0.124	0.474	0.21
03	0.197	0.086	0.473	0.245
04	0.19	0.207	0.416	0.188
05	0.153	0.065	0.721	0.061
06	0.091	0.008	0.876	0.025
07	0.016	0.003	0.491	0.49
08	0.002	0.008	0.989	0.002
09	0.004	0.008	0.979	0.01
10	0.016	0.0	0.1	0.884
11	0.016	0.887	0.08	0.017
12	0.025	0.015	0.903	0.057
13	0.227	0.41	0.059	0.304
14	0.185	0.206	0.407	0.202

PWM

	A	C	G	T
01	-0.341	-0.677	0.659	-0.164
02	-0.266	-0.699	0.639	-0.172
03	-0.239	-1.071	0.637	-0.02
04	-0.275	-0.19	0.509	-0.287
05	-0.49	-1.347	1.058	-1.405
06	-1.014	-3.379	1.253	-2.295
07	-2.706	-4.471	0.674	0.672
08	-4.817	-3.417	1.374	-4.927
09	-4.106	-3.469	1.364	-3.199
10	-2.738	-6.586	-0.914	1.262
11	-2.745	1.265	-1.134	-2.657
12	-2.283	-2.805	1.284	-1.481
13	-0.097	0.494	-1.439	0.196
14	-0.301	-0.192	0.486	-0.212

Standard thresholds

P-value	Threshold
0.001	4.11276
0.0005	5.14806
0.0001	7.24986