XBP1.H12RSNP.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	XBP1.H12RSNP.0.PS.A
Gene (human)	XBP1 (GeneCards)
Gene synonyms (human)	TREB5, XBP2
Gene (mouse)	Xbp1
Gene synonyms (mouse)	Treb5
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	14
Consensus	ndvRTGACGTRdvn
GC content	56.98%
Information content (bits; total / per base)	13.229 / 0.945
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1490

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (19)	0.732	0.808	0.653	0.714	0.68	0.78	2.325	2.727	132.066	157.301
Mouse	5 (34)	0.821	0.896	0.752	0.84	0.771	0.866	2.92	3.347	117.018	311.0

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.925	0.911	0.843	0.807	0.801	0.756
Overall, 6 experiments	best	0.984	0.974	0.968	0.952	0.935	0.913
Methyl HT-SELEX, 2 experiments	median	0.894	0.86	0.843	0.801	0.801	0.756
Methyl HT-SELEX, 2 experiments	best	0.956	0.936	0.907	0.876	0.866	0.826
Non-Methyl HT-SELEX, 4 experiments	median	0.93	0.915	0.833	0.822	0.758	0.753
Non-Methyl HT-SELEX, 4 experiments	best	0.984	0.974	0.968	0.952	0.935	0.913

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.835	0.343	0.743	0.519

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	XBP1-related {1.1.5} (TFClass)
TF subfamily	{1.1.5.0} (TFClass)
TFClass ID	TFClass: 1.1.5.0.1
HGNC	HGNC:12801
MGI	MGI:98970
EntrezGene (human)	GeneID:7494 (SSTAR profile)
EntrezGene (mouse)	GeneID:22433 (SSTAR profile)
UniProt ID (human)	XBP1_HUMAN
UniProt ID (mouse)	XBP1_MOUSE
UniProt AC (human)	P17861 (TFClass)
UniProt AC (mouse)	O35426 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 5 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	XBP1.H12RSNP.0.PS.A.pcm
PWM	XBP1.H12RSNP.0.PS.A.pwm
PFM	XBP1.H12RSNP.0.PS.A.pfm
Alignment	XBP1.H12RSNP.0.PS.A.words.tsv
Threshold to P-value map	XBP1.H12RSNP.0.PS.A.thr
Motif in other formats
JASPAR format	XBP1.H12RSNP.0.PS.A_jaspar_format.txt
MEME format	XBP1.H12RSNP.0.PS.A_meme_format.meme
Transfac format	XBP1.H12RSNP.0.PS.A_transfac_format.txt
Homer format	XBP1.H12RSNP.0.PS.A_homer_format_0.001.txt XBP1.H12RSNP.0.PS.A_homer_format_0.0005.txt XBP1.H12RSNP.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	435.0	281.0	489.0	285.0
02	343.75	202.75	578.75	364.75
03	221.0	326.0	803.0	140.0
04	668.0	167.0	596.0	59.0
05	24.0	65.0	42.0	1359.0
06	5.0	91.0	1333.0	61.0
07	1489.0	0.0	1.0	0.0
08	0.0	1490.0	0.0	0.0
09	0.0	0.0	1490.0	0.0
10	0.0	5.0	0.0	1485.0
11	243.0	78.0	1130.0	39.0
12	222.0	63.0	803.0	402.0
13	232.5	749.5	276.5	231.5
14	424.75	355.75	468.75	240.75

PFM

	A	C	G	T
01	0.292	0.189	0.328	0.191
02	0.231	0.136	0.388	0.245
03	0.148	0.219	0.539	0.094
04	0.448	0.112	0.4	0.04
05	0.016	0.044	0.028	0.912
06	0.003	0.061	0.895	0.041
07	0.999	0.0	0.001	0.0
08	0.0	1.0	0.0	0.0
09	0.0	0.0	1.0	0.0
10	0.0	0.003	0.0	0.997
11	0.163	0.052	0.758	0.026
12	0.149	0.042	0.539	0.27
13	0.156	0.503	0.186	0.155
14	0.285	0.239	0.315	0.162

PWM

	A	C	G	T
01	0.154	-0.28	0.271	-0.266
02	-0.08	-0.604	0.439	-0.021
03	-0.519	-0.133	0.765	-0.971
04	0.582	-0.796	0.468	-1.817
05	-2.674	-1.723	-2.145	1.291
06	-4.004	-1.394	1.271	-1.785
07	1.382	-5.323	-4.886	-5.323
08	-5.323	1.383	-5.323	-5.323
09	-5.323	-5.323	1.383	-5.323
10	-5.323	-4.004	-5.323	1.379
11	-0.425	-1.545	1.106	-2.216
12	-0.514	-1.753	0.765	0.076
13	-0.468	0.697	-0.296	-0.473
14	0.131	-0.046	0.229	-0.434

Standard thresholds

P-value	Threshold
0.001	3.21351
0.0005	4.54966
0.0001	7.170775