XBP1.H12INVIVO.1.M.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	XBP1.H12INVIVO.1.M.B
Gene (human)	XBP1 (GeneCards)
Gene synonyms (human)	TREB5, XBP2
Gene (mouse)	Xbp1
Gene synonyms (mouse)	Treb5
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	14
Consensus	dbSRTGACKYvnbn
GC content	55.49%
Information content (bits; total / per base)	10.563 / 0.755
Data sources	Methyl-HT-SELEX
Aligned words	2291

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (19)	0.684	0.725	0.577	0.628	0.667	0.702	1.987	2.194	82.854	102.585
Mouse	5 (34)	0.727	0.763	0.624	0.667	0.692	0.719	2.187	2.564	66.45	126.337

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.938	0.905	0.897	0.857	0.826	0.791
Overall, 6 experiments	best	0.98	0.967	0.957	0.938	0.905	0.879
Methyl HT-SELEX, 2 experiments	median	0.952	0.926	0.922	0.889	0.864	0.832
Methyl HT-SELEX, 2 experiments	best	0.976	0.962	0.954	0.933	0.905	0.879
Non-Methyl HT-SELEX, 4 experiments	median	0.901	0.885	0.783	0.779	0.698	0.701
Non-Methyl HT-SELEX, 4 experiments	best	0.98	0.967	0.957	0.938	0.897	0.875

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.694	0.107	0.636	0.443

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	XBP1-related {1.1.5} (TFClass)
TF subfamily	{1.1.5.0} (TFClass)
TFClass ID	TFClass: 1.1.5.0.1
HGNC	HGNC:12801
MGI	MGI:98970
EntrezGene (human)	GeneID:7494 (SSTAR profile)
EntrezGene (mouse)	GeneID:22433 (SSTAR profile)
UniProt ID (human)	XBP1_HUMAN
UniProt ID (mouse)	XBP1_MOUSE
UniProt AC (human)	P17861 (TFClass)
UniProt AC (mouse)	O35426 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 5 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	XBP1.H12INVIVO.1.M.B.pcm
PWM	XBP1.H12INVIVO.1.M.B.pwm
PFM	XBP1.H12INVIVO.1.M.B.pfm
Alignment	XBP1.H12INVIVO.1.M.B.words.tsv
Threshold to P-value map	XBP1.H12INVIVO.1.M.B.thr
Motif in other formats
JASPAR format	XBP1.H12INVIVO.1.M.B_jaspar_format.txt
MEME format	XBP1.H12INVIVO.1.M.B_meme_format.meme
Transfac format	XBP1.H12INVIVO.1.M.B_transfac_format.txt
Homer format	XBP1.H12INVIVO.1.M.B_homer_format_0.001.txt XBP1.H12INVIVO.1.M.B_homer_format_0.0005.txt XBP1.H12INVIVO.1.M.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	915.25	278.25	804.25	293.25
02	285.0	517.0	733.0	756.0
03	160.0	319.0	1747.0	65.0
04	1367.0	377.0	520.0	27.0
05	6.0	10.0	38.0	2237.0
06	19.0	1.0	2250.0	21.0
07	2285.0	0.0	6.0	0.0
08	2.0	1813.0	146.0	330.0
09	119.0	26.0	1712.0	434.0
10	275.0	798.0	75.0	1143.0
11	658.0	311.0	1072.0	250.0
12	498.0	337.0	829.0	627.0
13	262.75	1366.75	346.75	314.75
14	584.0	618.0	748.0	341.0

PFM

	A	C	G	T
01	0.399	0.121	0.351	0.128
02	0.124	0.226	0.32	0.33
03	0.07	0.139	0.763	0.028
04	0.597	0.165	0.227	0.012
05	0.003	0.004	0.017	0.976
06	0.008	0.0	0.982	0.009
07	0.997	0.0	0.003	0.0
08	0.001	0.791	0.064	0.144
09	0.052	0.011	0.747	0.189
10	0.12	0.348	0.033	0.499
11	0.287	0.136	0.468	0.109
12	0.217	0.147	0.362	0.274
13	0.115	0.597	0.151	0.137
14	0.255	0.27	0.326	0.149

PWM

	A	C	G	T
01	0.467	-0.718	0.338	-0.666
02	-0.695	-0.102	0.246	0.277
03	-1.267	-0.583	1.113	-2.15
04	0.868	-0.416	-0.096	-2.989
05	-4.283	-3.874	-2.667	1.36
06	-3.312	-5.277	1.366	-3.221
07	1.381	-5.694	-4.283	-5.694
08	-4.984	1.15	-1.357	-0.549
09	-1.559	-3.024	1.093	-0.276
10	-0.73	0.331	-2.011	0.689
11	0.138	-0.608	0.625	-0.825
12	-0.139	-0.528	0.369	0.09
13	-0.775	0.868	-0.5	-0.596
14	0.019	0.076	0.266	-0.516

Standard thresholds

P-value	Threshold
0.001	4.67251
0.0005	5.62241
0.0001	7.40591