XBP1.H12INVIVO.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	XBP1.H12INVIVO.0.PS.A
Gene (human)	XBP1 (GeneCards)
Gene synonyms (human)	TREB5, XBP2
Gene (mouse)	Xbp1
Gene synonyms (mouse)	Treb5
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	11
Consensus	RvhbACGTGKM
GC content	62.4%
Information content (bits; total / per base)	10.172 / 0.925
Data sources	ChIP-Seq + HT-SELEX
Aligned words	995

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (19)	0.747	0.826	0.69	0.738	0.709	0.813	2.625	3.044	153.77	194.509
Mouse	5 (34)	0.832	0.901	0.767	0.843	0.814	0.883	3.184	3.649	137.102	382.292

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.928	0.913	0.865	0.823	0.796	0.761
Overall, 6 experiments	best	0.976	0.961	0.957	0.936	0.916	0.889
Methyl HT-SELEX, 2 experiments	median	0.912	0.873	0.865	0.823	0.796	0.761
Methyl HT-SELEX, 2 experiments	best	0.959	0.936	0.924	0.894	0.857	0.827
Non-Methyl HT-SELEX, 4 experiments	median	0.93	0.914	0.827	0.818	0.746	0.742
Non-Methyl HT-SELEX, 4 experiments	best	0.976	0.961	0.957	0.936	0.916	0.889

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.801	0.182	0.684	0.495

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	XBP1-related {1.1.5} (TFClass)
TF subfamily	{1.1.5.0} (TFClass)
TFClass ID	TFClass: 1.1.5.0.1
HGNC	HGNC:12801
MGI	MGI:98970
EntrezGene (human)	GeneID:7494 (SSTAR profile)
EntrezGene (mouse)	GeneID:22433 (SSTAR profile)
UniProt ID (human)	XBP1_HUMAN
UniProt ID (mouse)	XBP1_MOUSE
UniProt AC (human)	P17861 (TFClass)
UniProt AC (mouse)	O35426 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 5 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	XBP1.H12INVIVO.0.PS.A.pcm
PWM	XBP1.H12INVIVO.0.PS.A.pwm
PFM	XBP1.H12INVIVO.0.PS.A.pfm
Alignment	XBP1.H12INVIVO.0.PS.A.words.tsv
Threshold to P-value map	XBP1.H12INVIVO.0.PS.A.thr
Motif in other formats
JASPAR format	XBP1.H12INVIVO.0.PS.A_jaspar_format.txt
MEME format	XBP1.H12INVIVO.0.PS.A_meme_format.meme
Transfac format	XBP1.H12INVIVO.0.PS.A_transfac_format.txt
Homer format	XBP1.H12INVIVO.0.PS.A_homer_format_0.001.txt XBP1.H12INVIVO.0.PS.A_homer_format_0.0005.txt XBP1.H12INVIVO.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	177.0	86.0	600.0	132.0
02	195.0	345.0	399.0	56.0
03	159.0	138.0	126.0	572.0
04	51.0	280.0	519.0	145.0
05	927.0	14.0	35.0	19.0
06	14.0	839.0	61.0	81.0
07	28.0	37.0	922.0	8.0
08	13.0	25.0	4.0	953.0
09	17.0	20.0	937.0	21.0
10	55.0	30.0	656.0	254.0
11	150.0	661.0	96.0	88.0

PFM

	A	C	G	T
01	0.178	0.086	0.603	0.133
02	0.196	0.347	0.401	0.056
03	0.16	0.139	0.127	0.575
04	0.051	0.281	0.522	0.146
05	0.932	0.014	0.035	0.019
06	0.014	0.843	0.061	0.081
07	0.028	0.037	0.927	0.008
08	0.013	0.025	0.004	0.958
09	0.017	0.02	0.942	0.021
10	0.055	0.03	0.659	0.255
11	0.151	0.664	0.096	0.088

PWM

	A	C	G	T
01	-0.338	-1.049	0.876	-0.628
02	-0.242	0.325	0.47	-1.468
03	-0.444	-0.584	-0.673	0.829
04	-1.558	0.118	0.732	-0.535
05	1.31	-2.768	-1.92	-2.492
06	-2.768	1.211	-1.385	-1.108
07	-2.131	-1.867	1.305	-3.249
08	-2.834	-2.238	-3.778	1.338
09	-2.593	-2.445	1.321	-2.4
10	-1.485	-2.066	0.965	0.021
11	-0.501	0.973	-0.941	-1.027

Standard thresholds

P-value	Threshold
0.001	4.672225
0.0005	5.52786
0.0001	7.29442