XBP1.H12INVITRO.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	XBP1.H12INVITRO.0.PS.A
Gene (human)	XBP1 (GeneCards)
Gene synonyms (human)	TREB5, XBP2
Gene (mouse)	Xbp1
Gene synonyms (mouse)	Treb5
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	12
Consensus	nvvWKACGTRdh
GC content	55.2%
Information content (bits; total / per base)	9.986 / 0.832
Data sources	ChIP-Seq + HT-SELEX
Aligned words	9930

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (19)	0.756	0.83	0.686	0.739	0.693	0.785	2.484	2.842	151.31	193.77
Mouse	5 (34)	0.836	0.909	0.764	0.848	0.771	0.866	2.985	3.392	148.068	354.469

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.936	0.922	0.858	0.816	0.807	0.765
Overall, 6 experiments	best	0.985	0.975	0.969	0.954	0.946	0.923
Methyl HT-SELEX, 2 experiments	median	0.904	0.869	0.858	0.816	0.807	0.765
Methyl HT-SELEX, 2 experiments	best	0.957	0.937	0.917	0.887	0.869	0.833
Non-Methyl HT-SELEX, 4 experiments	median	0.941	0.927	0.839	0.832	0.763	0.761
Non-Methyl HT-SELEX, 4 experiments	best	0.985	0.975	0.969	0.954	0.946	0.923

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.849	0.341	0.708	0.512

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	XBP1-related {1.1.5} (TFClass)
TF subfamily	{1.1.5.0} (TFClass)
TFClass ID	TFClass: 1.1.5.0.1
HGNC	HGNC:12801
MGI	MGI:98970
EntrezGene (human)	GeneID:7494 (SSTAR profile)
EntrezGene (mouse)	GeneID:22433 (SSTAR profile)
UniProt ID (human)	XBP1_HUMAN
UniProt ID (mouse)	XBP1_MOUSE
UniProt AC (human)	P17861 (TFClass)
UniProt AC (mouse)	O35426 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 5 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	XBP1.H12INVITRO.0.PS.A.pcm
PWM	XBP1.H12INVITRO.0.PS.A.pwm
PFM	XBP1.H12INVITRO.0.PS.A.pfm
Alignment	XBP1.H12INVITRO.0.PS.A.words.tsv
Threshold to P-value map	XBP1.H12INVITRO.0.PS.A.thr
Motif in other formats
JASPAR format	XBP1.H12INVITRO.0.PS.A_jaspar_format.txt
MEME format	XBP1.H12INVITRO.0.PS.A_meme_format.meme
Transfac format	XBP1.H12INVITRO.0.PS.A_transfac_format.txt
Homer format	XBP1.H12INVITRO.0.PS.A_homer_format_0.001.txt XBP1.H12INVITRO.0.PS.A_homer_format_0.0005.txt XBP1.H12INVITRO.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2056.75	2290.75	2569.75	3012.75
02	1688.0	1577.0	5117.0	1548.0
03	3947.0	1882.0	2976.0	1125.0
04	1300.0	968.0	792.0	6870.0
05	393.0	1136.0	6982.0	1419.0
06	9868.0	5.0	56.0	1.0
07	16.0	9842.0	31.0	41.0
08	102.0	22.0	9725.0	81.0
09	382.0	688.0	185.0	8675.0
10	1081.0	786.0	7386.0	677.0
11	946.75	568.75	4202.75	4211.75
12	1982.0	4472.0	1512.0	1964.0

PFM

	A	C	G	T
01	0.207	0.231	0.259	0.303
02	0.17	0.159	0.515	0.156
03	0.397	0.19	0.3	0.113
04	0.131	0.097	0.08	0.692
05	0.04	0.114	0.703	0.143
06	0.994	0.001	0.006	0.0
07	0.002	0.991	0.003	0.004
08	0.01	0.002	0.979	0.008
09	0.038	0.069	0.019	0.874
10	0.109	0.079	0.744	0.068
11	0.095	0.057	0.423	0.424
12	0.2	0.45	0.152	0.198

PWM

	A	C	G	T
01	-0.188	-0.08	0.035	0.193
02	-0.385	-0.453	0.723	-0.472
03	0.463	-0.277	0.181	-0.79
04	-0.646	-0.94	-1.14	1.017
05	-1.838	-0.781	1.033	-0.559
06	1.379	-5.83	-3.752	-6.624
07	-4.911	1.377	-4.312	-4.05
08	-3.171	-4.627	1.365	-3.395
09	-1.867	-1.281	-2.585	1.251
10	-0.83	-1.148	1.09	-1.297
11	-0.962	-1.47	0.526	0.528
12	-0.225	0.588	-0.495	-0.234

Standard thresholds

P-value	Threshold
0.001	4.82941
0.0005	5.708225
0.0001	7.369055