XBP1.H12CORE.1.M.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	XBP1.H12CORE.1.M.B
Gene (human)	XBP1 (GeneCards)
Gene synonyms (human)	TREB5, XBP2
Gene (mouse)	Xbp1
Gene synonyms (mouse)	Treb5
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	14
Consensus	dbGRTGACGYvdSn
GC content	55.49%
Information content (bits; total / per base)	11.35 / 0.811
Data sources	Methyl-HT-SELEX
Aligned words	1983

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (19)	0.682	0.72	0.577	0.624	0.668	0.698	1.993	2.175	81.959	104.569
Mouse	5 (34)	0.721	0.759	0.618	0.663	0.69	0.72	2.18	2.548	72.512	130.432

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.938	0.904	0.897	0.857	0.827	0.791
Overall, 6 experiments	best	0.98	0.967	0.956	0.937	0.905	0.88
Methyl HT-SELEX, 2 experiments	median	0.953	0.926	0.922	0.889	0.865	0.832
Methyl HT-SELEX, 2 experiments	best	0.976	0.962	0.954	0.933	0.905	0.88
Non-Methyl HT-SELEX, 4 experiments	median	0.901	0.885	0.784	0.779	0.7	0.702
Non-Methyl HT-SELEX, 4 experiments	best	0.98	0.967	0.956	0.937	0.899	0.876

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.707	0.102	0.643	0.458

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	XBP1-related {1.1.5} (TFClass)
TF subfamily	{1.1.5.0} (TFClass)
TFClass ID	TFClass: 1.1.5.0.1
HGNC	HGNC:12801
MGI	MGI:98970
EntrezGene (human)	GeneID:7494 (SSTAR profile)
EntrezGene (mouse)	GeneID:22433 (SSTAR profile)
UniProt ID (human)	XBP1_HUMAN
UniProt ID (mouse)	XBP1_MOUSE
UniProt AC (human)	P17861 (TFClass)
UniProt AC (mouse)	O35426 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 5 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	XBP1.H12CORE.1.M.B.pcm
PWM	XBP1.H12CORE.1.M.B.pwm
PFM	XBP1.H12CORE.1.M.B.pfm
Alignment	XBP1.H12CORE.1.M.B.words.tsv
Threshold to P-value map	XBP1.H12CORE.1.M.B.thr
Motif in other formats
JASPAR format	XBP1.H12CORE.1.M.B_jaspar_format.txt
MEME format	XBP1.H12CORE.1.M.B_meme_format.meme
Transfac format	XBP1.H12CORE.1.M.B_transfac_format.txt
Homer format	XBP1.H12CORE.1.M.B_homer_format_0.001.txt XBP1.H12CORE.1.M.B_homer_format_0.0005.txt XBP1.H12CORE.1.M.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	816.75	223.75	696.75	245.75
02	215.25	428.25	636.25	703.25
03	105.0	247.0	1583.0	48.0
04	1260.0	306.0	407.0	10.0
05	2.0	6.0	14.0	1961.0
06	17.0	0.0	1949.0	17.0
07	1981.0	0.0	2.0	0.0
08	0.0	1621.0	103.0	259.0
09	84.0	14.0	1533.0	352.0
10	211.0	670.0	46.0	1056.0
11	591.0	250.0	948.0	194.0
12	427.0	263.0	743.0	550.0
13	203.0	1262.0	265.0	253.0
14	505.25	509.25	680.25	288.25

PFM

	A	C	G	T
01	0.412	0.113	0.351	0.124
02	0.109	0.216	0.321	0.355
03	0.053	0.125	0.798	0.024
04	0.635	0.154	0.205	0.005
05	0.001	0.003	0.007	0.989
06	0.009	0.0	0.983	0.009
07	0.999	0.0	0.001	0.0
08	0.0	0.817	0.052	0.131
09	0.042	0.007	0.773	0.178
10	0.106	0.338	0.023	0.533
11	0.298	0.126	0.478	0.098
12	0.215	0.133	0.375	0.277
13	0.102	0.636	0.134	0.128
14	0.255	0.257	0.343	0.145

PWM

	A	C	G	T
01	0.498	-0.791	0.339	-0.698
02	-0.829	-0.146	0.249	0.349
03	-1.538	-0.693	1.158	-2.3
04	0.93	-0.48	-0.196	-3.734
05	-4.849	-4.143	-3.444	1.372
06	-3.271	-5.569	1.366	-3.271
07	1.382	-5.569	-4.849	-5.569
08	-5.569	1.182	-1.557	-0.646
09	-1.757	-3.444	1.126	-0.341
10	-0.849	0.3	-2.341	0.754
11	0.175	-0.681	0.646	-0.932
12	-0.149	-0.631	0.403	0.103
13	-0.887	0.932	-0.623	-0.669
14	0.019	0.027	0.315	-0.54

Standard thresholds

P-value	Threshold
0.001	4.38511
0.0005	5.42801
0.0001	7.38831