| Motif | USF2.H12RSNP.0.PSM.A |
| Gene (human) | USF2 (GeneCards) |
| Gene synonyms (human) | BHLHB12 |
| Gene (mouse) | Usf2 |
| Gene synonyms (mouse) | |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | A |
| Motif | USF2.H12RSNP.0.PSM.A |
| Gene (human) | USF2 (GeneCards) |
| Gene synonyms (human) | BHLHB12 |
| Gene (mouse) | Usf2 |
| Gene synonyms (mouse) | |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | A |
| Motif length | 18 |
| Consensus | nnnnndRYCACRTGvbbn |
| GC content | 56.44% |
| Information content (bits; total / per base) | 11.931 / 0.663 |
| Data sources | ChIP-Seq + HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 877 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 14 (93) | 0.982 | 0.994 | 0.96 | 0.985 | 0.977 | 0.993 | 5.681 | 6.445 | 694.886 | 830.921 |
| Mouse | 5 (33) | 0.969 | 0.992 | 0.95 | 0.98 | 0.966 | 0.993 | 5.724 | 6.358 | 513.174 | 887.097 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 4 experiments | median | 0.999 | 0.998 | 0.996 | 0.995 | 0.948 | 0.95 |
| best | 0.999 | 0.999 | 0.998 | 0.997 | 0.997 | 0.995 | |
| Methyl HT-SELEX, 2 experiments | median | 0.999 | 0.998 | 0.996 | 0.995 | 0.949 | 0.951 |
| best | 0.999 | 0.998 | 0.998 | 0.997 | 0.997 | 0.995 | |
| Non-Methyl HT-SELEX, 2 experiments | median | 0.999 | 0.998 | 0.953 | 0.957 | 0.86 | 0.878 |
| best | 0.999 | 0.999 | 0.998 | 0.996 | 0.997 | 0.995 | |
| rSNP benchmarking, ADASTRA | odds-ratio | -log-Fisher's P | Pearson r | Kendall tau |
|---|---|---|---|---|
| # | 6.468 | 5.881 | 0.201 | 0.114 |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 2 | 0.933 | 0.55 | 0.849 | 0.605 |
| TF superclass | Basic domains {1} (TFClass) |
| TF class | Basic helix-loop-helix factors (bHLH) {1.2} (TFClass) |
| TF family | bHLH-ZIP {1.2.6} (TFClass) |
| TF subfamily | USF {1.2.6.2} (TFClass) |
| TFClass ID | TFClass: 1.2.6.2.2 |
| HGNC | HGNC:12594 |
| MGI | MGI:99961 |
| EntrezGene (human) | GeneID:7392 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:22282 (SSTAR profile) |
| UniProt ID (human) | USF2_HUMAN |
| UniProt ID (mouse) | USF2_MOUSE |
| UniProt AC (human) | Q15853 (TFClass) |
| UniProt AC (mouse) | Q64705 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 14 human, 5 mouse |
| HT-SELEX | 2 |
| Methyl-HT-SELEX | 2 |
| PCM | USF2.H12RSNP.0.PSM.A.pcm |
| PWM | USF2.H12RSNP.0.PSM.A.pwm |
| PFM | USF2.H12RSNP.0.PSM.A.pfm |
| Alignment | USF2.H12RSNP.0.PSM.A.words.tsv |
| Threshold to P-value map | USF2.H12RSNP.0.PSM.A.thr |
| Motif in other formats | |
| JASPAR format | USF2.H12RSNP.0.PSM.A_jaspar_format.txt |
| MEME format | USF2.H12RSNP.0.PSM.A_meme_format.meme |
| Transfac format | USF2.H12RSNP.0.PSM.A_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 199.0 | 208.0 | 271.0 | 199.0 |
| 02 | 231.0 | 279.0 | 213.0 | 154.0 |
| 03 | 221.0 | 219.0 | 218.0 | 219.0 |
| 04 | 188.0 | 243.0 | 245.0 | 201.0 |
| 05 | 287.0 | 183.0 | 223.0 | 184.0 |
| 06 | 244.0 | 89.0 | 377.0 | 167.0 |
| 07 | 152.0 | 96.0 | 604.0 | 25.0 |
| 08 | 40.0 | 153.0 | 31.0 | 653.0 |
| 09 | 2.0 | 873.0 | 0.0 | 2.0 |
| 10 | 868.0 | 8.0 | 0.0 | 1.0 |
| 11 | 5.0 | 774.0 | 52.0 | 46.0 |
| 12 | 185.0 | 27.0 | 656.0 | 9.0 |
| 13 | 14.0 | 22.0 | 15.0 | 826.0 |
| 14 | 4.0 | 8.0 | 852.0 | 13.0 |
| 15 | 329.0 | 169.0 | 279.0 | 100.0 |
| 16 | 55.0 | 341.0 | 146.0 | 335.0 |
| 17 | 116.0 | 378.0 | 202.0 | 181.0 |
| 18 | 260.0 | 282.0 | 174.0 | 161.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.227 | 0.237 | 0.309 | 0.227 |
| 02 | 0.263 | 0.318 | 0.243 | 0.176 |
| 03 | 0.252 | 0.25 | 0.249 | 0.25 |
| 04 | 0.214 | 0.277 | 0.279 | 0.229 |
| 05 | 0.327 | 0.209 | 0.254 | 0.21 |
| 06 | 0.278 | 0.101 | 0.43 | 0.19 |
| 07 | 0.173 | 0.109 | 0.689 | 0.029 |
| 08 | 0.046 | 0.174 | 0.035 | 0.745 |
| 09 | 0.002 | 0.995 | 0.0 | 0.002 |
| 10 | 0.99 | 0.009 | 0.0 | 0.001 |
| 11 | 0.006 | 0.883 | 0.059 | 0.052 |
| 12 | 0.211 | 0.031 | 0.748 | 0.01 |
| 13 | 0.016 | 0.025 | 0.017 | 0.942 |
| 14 | 0.005 | 0.009 | 0.971 | 0.015 |
| 15 | 0.375 | 0.193 | 0.318 | 0.114 |
| 16 | 0.063 | 0.389 | 0.166 | 0.382 |
| 17 | 0.132 | 0.431 | 0.23 | 0.206 |
| 18 | 0.296 | 0.322 | 0.198 | 0.184 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.096 | -0.052 | 0.21 | -0.096 |
| 02 | 0.052 | 0.239 | -0.029 | -0.35 |
| 03 | 0.008 | -0.001 | -0.006 | -0.001 |
| 04 | -0.152 | 0.102 | 0.11 | -0.086 |
| 05 | 0.267 | -0.179 | 0.017 | -0.174 |
| 06 | 0.106 | -0.89 | 0.539 | -0.27 |
| 07 | -0.363 | -0.816 | 1.008 | -2.113 |
| 08 | -1.668 | -0.356 | -1.911 | 1.086 |
| 09 | -4.091 | 1.376 | -4.871 | -4.091 |
| 10 | 1.37 | -3.126 | -4.871 | -4.407 |
| 11 | -3.497 | 1.256 | -1.415 | -1.533 |
| 12 | -0.168 | -2.041 | 1.091 | -3.028 |
| 13 | -2.645 | -2.233 | -2.583 | 1.321 |
| 14 | -3.658 | -3.126 | 1.352 | -2.71 |
| 15 | 0.403 | -0.258 | 0.239 | -0.776 |
| 16 | -1.36 | 0.439 | -0.403 | 0.421 |
| 17 | -0.63 | 0.541 | -0.081 | -0.19 |
| 18 | 0.169 | 0.25 | -0.229 | -0.306 |
| P-value | Threshold |
|---|---|
| 0.001 | 4.13871 |
| 0.0005 | 5.17926 |
| 0.0001 | 7.29181 |