MotifTLX3.H12CORE.0.SM.B
Gene (human)TLX3
(GeneCards)
Gene synonyms (human)HOX11L2
Gene (mouse)Tlx3
Gene synonyms (mouse)Hox11l2, Rnx, Tlx1l2
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
B
Motif length12
ConsensusnhSTTAAYKRnn
GC content35.32%
Information content (bits; total / per base)9.872 / 0.823
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words2244

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 3 experiments median 0.724 0.669 0.662 0.62 0.607 0.585
best 0.785 0.724 0.72 0.671 0.652 0.625
Methyl HT-SELEX, 2 experiments median 0.755 0.697 0.687 0.645 0.624 0.603
best 0.785 0.724 0.72 0.671 0.652 0.625
Non-Methyl HT-SELEX, 1 experiments median 0.717 0.659 0.662 0.619 0.607 0.585
best 0.717 0.659 0.662 0.619 0.607 0.585

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.592 0.127 0.514 0.302
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyNK-related {3.1.2} (TFClass)
TF subfamilyTLX {3.1.2.21} (TFClass)
TFClass IDTFClass: 3.1.2.21.3
HGNCHGNC:13532
MGIMGI:1351209
EntrezGene (human)GeneID:30012
(SSTAR profile)
EntrezGene (mouse)GeneID:27140
(SSTAR profile)
UniProt ID (human)TLX3_HUMAN
UniProt ID (mouse)TLX3_MOUSE
UniProt AC (human)O43711
(TFClass)
UniProt AC (mouse)O55144
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 0 human, 0 mouse
HT-SELEX 1
Methyl-HT-SELEX 2
PCM
ACGT
01762.25351.25504.25626.25
02417.751152.75291.75381.75
03421.0450.01278.095.0
0422.0176.041.02005.0
050.012.00.02232.0
062243.00.01.00.0
072244.00.00.00.0
08195.0391.0195.01463.0
09144.0195.0743.01162.0
101025.036.01146.037.0
11549.75635.75696.75361.75
12444.0624.0591.0585.0
PFM
ACGT
010.340.1570.2250.279
020.1860.5140.130.17
030.1880.2010.570.042
040.010.0780.0180.893
050.00.0050.00.995
061.00.00.00.0
071.00.00.00.0
080.0870.1740.0870.652
090.0640.0870.3310.518
100.4570.0160.5110.016
110.2450.2830.310.161
120.1980.2780.2630.261
PWM
ACGT
010.306-0.466-0.1060.11
02-0.2940.718-0.651-0.383
03-0.286-0.220.821-1.759
04-3.158-1.152-2.5741.271
05-5.676-3.699-5.6761.378
061.383-5.676-5.258-5.676
071.384-5.676-5.676-5.676
08-1.05-0.36-1.050.956
09-1.35-1.050.280.726
100.601-2.6970.713-2.671
11-0.020.1250.216-0.437
12-0.2330.1060.0520.042
Standard thresholds
P-value Threshold
0.001 5.02587
0.0005 5.94969
0.0001 7.50333