THB.H12INVIVO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	THB.H12INVIVO.0.P.B
Gene (human)	THRB (GeneCards)
Gene synonyms (human)	ERBA2, NR1A2, THR1
Gene (mouse)	Thrb
Gene synonyms (mouse)	Erba2, Nr1a2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	17
Consensus	vRGKKSRnnYvAGGhSA
GC content	56.87%
Information content (bits; total / per base)	13.005 / 0.765
Data sources	ChIP-Seq
Aligned words	1001

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.884	0.891	0.77	0.782	0.908	0.915	4.329	4.426	309.854	341.292
Mouse	1 (5)	0.706	0.762	0.66	0.745	0.669	0.74	2.629	3.186	78.432	120.959

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.859	0.815	0.786	0.743	0.711	0.681
Overall, 6 experiments	best	0.957	0.943	0.895	0.867	0.838	0.801
Methyl HT-SELEX, 2 experiments	median	0.919	0.892	0.851	0.817	0.78	0.749
Methyl HT-SELEX, 2 experiments	best	0.957	0.943	0.894	0.867	0.829	0.797
Non-Methyl HT-SELEX, 4 experiments	median	0.714	0.678	0.657	0.63	0.607	0.593
Non-Methyl HT-SELEX, 4 experiments	best	0.946	0.927	0.895	0.863	0.838	0.801

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Thyroid hormone receptor-related {2.1.2} (TFClass)
TF subfamily	T3R (NR1A) {2.1.2.2} (TFClass)
TFClass ID	TFClass: 2.1.2.2.2
HGNC	HGNC:11799
MGI	MGI:98743
EntrezGene (human)	GeneID:7068 (SSTAR profile)
EntrezGene (mouse)	GeneID:21834 (SSTAR profile)
UniProt ID (human)	THB_HUMAN
UniProt ID (mouse)	THB_MOUSE
UniProt AC (human)	P10828 (TFClass)
UniProt AC (mouse)	P37242 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 1 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	THB.H12INVIVO.0.P.B.pcm
PWM	THB.H12INVIVO.0.P.B.pwm
PFM	THB.H12INVIVO.0.P.B.pfm
Alignment	THB.H12INVIVO.0.P.B.words.tsv
Threshold to P-value map	THB.H12INVIVO.0.P.B.thr
Motif in other formats
JASPAR format	THB.H12INVIVO.0.P.B_jaspar_format.txt
MEME format	THB.H12INVIVO.0.P.B_meme_format.meme
Transfac format	THB.H12INVIVO.0.P.B_transfac_format.txt
Homer format	THB.H12INVIVO.0.P.B_homer_format_0.001.txt THB.H12INVIVO.0.P.B_homer_format_0.0005.txt THB.H12INVIVO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	295.0	171.0	429.0	106.0
02	511.0	25.0	455.0	10.0
03	71.0	15.0	871.0	44.0
04	105.0	16.0	746.0	134.0
05	17.0	106.0	167.0	711.0
06	55.0	694.0	127.0	125.0
07	777.0	54.0	105.0	65.0
08	169.0	310.0	237.0	285.0
09	171.0	395.0	200.0	235.0
10	34.0	304.0	82.0	581.0
11	227.0	232.0	477.0	65.0
12	733.0	12.0	250.0	6.0
13	4.0	1.0	985.0	11.0
14	6.0	3.0	957.0	35.0
15	297.0	164.0	94.0	446.0
16	64.0	763.0	96.0	78.0
17	809.0	51.0	84.0	57.0

PFM

	A	C	G	T
01	0.295	0.171	0.429	0.106
02	0.51	0.025	0.455	0.01
03	0.071	0.015	0.87	0.044
04	0.105	0.016	0.745	0.134
05	0.017	0.106	0.167	0.71
06	0.055	0.693	0.127	0.125
07	0.776	0.054	0.105	0.065
08	0.169	0.31	0.237	0.285
09	0.171	0.395	0.2	0.235
10	0.034	0.304	0.082	0.58
11	0.227	0.232	0.477	0.065
12	0.732	0.012	0.25	0.006
13	0.004	0.001	0.984	0.011
14	0.006	0.003	0.956	0.035
15	0.297	0.164	0.094	0.446
16	0.064	0.762	0.096	0.078
17	0.808	0.051	0.084	0.057

PWM

	A	C	G	T
01	0.163	-0.378	0.536	-0.85
02	0.71	-2.244	0.595	-3.067
03	-1.243	-2.712	1.242	-1.707
04	-0.859	-2.654	1.088	-0.619
05	-2.599	-0.85	-0.401	1.04
06	-1.491	1.016	-0.672	-0.687
07	1.128	-1.509	-0.859	-1.329
08	-0.389	0.213	-0.054	0.129
09	-0.378	0.454	-0.222	-0.062
10	-1.953	0.193	-1.102	0.838
11	-0.097	-0.075	0.642	-1.329
12	1.07	-2.91	-0.001	-3.485
13	-3.784	-4.526	1.365	-2.986
14	-3.485	-3.976	1.336	-1.926
15	0.17	-0.419	-0.968	0.575
16	-1.344	1.11	-0.947	-1.151
17	1.169	-1.564	-1.078	-1.456

Standard thresholds

P-value	Threshold
0.001	3.93186
0.0005	4.92886
0.0001	6.99426