MotifTHB.H12INVITRO.2.SM.B
Gene (human)THRB
(GeneCards)
Gene synonyms (human)ERBA2, NR1A2, THR1
Gene (mouse)Thrb
Gene synonyms (mouse)Erba2, Nr1a2
LOGO
LOGO (reverse complement)
Motif subtype2
Quality
B
Motif length14
ConsensusRGGTCAAAGGTCAn
GC content49.85%
Information content (bits; total / per base)17.363 / 1.24
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words9779

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 1 (7) 0.712 0.725 0.539 0.552 0.656 0.661 1.681 1.702 29.699 33.959
Mouse 1 (5) 0.53 0.541 0.353 0.358 0.464 0.47 0.976 0.978 1.409 1.523

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 6 experiments median 0.851 0.78 0.82 0.751 0.776 0.716
best 1.0 1.0 1.0 1.0 0.981 0.98
Methyl HT-SELEX, 2 experiments median 0.921 0.885 0.904 0.869 0.871 0.839
best 0.999 0.999 0.997 0.996 0.977 0.973
Non-Methyl HT-SELEX, 4 experiments median 0.71 0.662 0.687 0.644 0.656 0.623
best 1.0 1.0 1.0 1.0 0.981 0.98
TF superclassZinc-coordinating DNA-binding domains {2} (TFClass)
TF classNuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF familyThyroid hormone receptor-related {2.1.2} (TFClass)
TF subfamilyT3R (NR1A) {2.1.2.2} (TFClass)
TFClass IDTFClass: 2.1.2.2.2
HGNCHGNC:11799
MGIMGI:98743
EntrezGene (human)GeneID:7068
(SSTAR profile)
EntrezGene (mouse)GeneID:21834
(SSTAR profile)
UniProt ID (human)THB_HUMAN
UniProt ID (mouse)THB_MOUSE
UniProt AC (human)P10828
(TFClass)
UniProt AC (mouse)P37242
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 1 human, 1 mouse
HT-SELEX 4
Methyl-HT-SELEX 2
PCM
ACGT
014296.75694.754269.75517.75
02464.0593.08242.0480.0
03326.0464.08092.0897.0
04266.0571.0652.08290.0
05379.08151.0451.0798.0
068999.0202.0329.0249.0
078287.072.0837.0583.0
089223.08.0547.01.0
092.04.09771.02.0
105.02.09423.0349.0
116.031.0341.09401.0
1256.08547.0213.0963.0
138058.25117.251487.25116.25
142472.02549.01593.03165.0
PFM
ACGT
010.4390.0710.4370.053
020.0470.0610.8430.049
030.0330.0470.8270.092
040.0270.0580.0670.848
050.0390.8340.0460.082
060.920.0210.0340.025
070.8470.0070.0860.06
080.9430.0010.0560.0
090.00.00.9990.0
100.0010.00.9640.036
110.0010.0030.0350.961
120.0060.8740.0220.098
130.8240.0120.1520.012
140.2530.2610.1630.324
PWM
ACGT
010.564-1.2560.557-1.549
02-1.658-1.4141.215-1.624
03-2.009-1.6581.196-1.001
04-2.211-1.451-1.3191.22
05-1.8591.204-1.686-1.118
061.302-2.483-2.0-2.276
071.22-3.495-1.07-1.431
081.327-5.471-1.494-6.61
09-6.345-5.9631.385-6.345
10-5.815-6.3451.349-1.941
11-5.687-4.297-1.9641.346
12-3.7371.251-2.431-0.93
131.192-3.019-0.496-3.027
140.0110.042-0.4280.258
Standard thresholds
P-value Threshold
0.001 1.42226
0.0005 2.82831
0.0001 5.69461