| Motif | THA.H12INVITRO.1.PS.A |
| Gene (human) | THRA (GeneCards) |
| Gene synonyms (human) | EAR7, ERBA1, NR1A1, THRA1, THRA2 |
| Gene (mouse) | Thra |
| Gene synonyms (mouse) | C-erba-alpha, Nr1a1 |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 1 |
| Quality | A |
| Motif | THA.H12INVITRO.1.PS.A |
| Gene (human) | THRA (GeneCards) |
| Gene synonyms (human) | EAR7, ERBA1, NR1A1, THRA1, THRA2 |
| Gene (mouse) | Thra |
| Gene synonyms (mouse) | C-erba-alpha, Nr1a1 |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 1 |
| Quality | A |
| Motif length | 8 |
| Consensus | YRAGGWCA |
| GC content | 54.22% |
| Information content (bits; total / per base) | 9.964 / 1.245 |
| Data sources | ChIP-Seq + HT-SELEX |
| Aligned words | 980 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 1 (6) | 0.821 | 0.866 | 0.7 | 0.717 | 0.817 | 0.868 | 2.412 | 2.705 | 40.658 | 138.018 |
| Mouse | 2 (12) | 0.798 | 0.816 | 0.647 | 0.67 | 0.771 | 0.784 | 2.044 | 2.079 | 154.956 | 192.481 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Non-Methyl HT-SELEX, 2 experiments | median | 0.783 | 0.771 | 0.649 | 0.655 | 0.573 | 0.591 |
| best | 0.852 | 0.839 | 0.688 | 0.697 | 0.593 | 0.616 | |
| TF superclass | Zinc-coordinating DNA-binding domains {2} (TFClass) |
| TF class | Nuclear receptors with C4 zinc fingers {2.1} (TFClass) |
| TF family | Thyroid hormone receptor-related {2.1.2} (TFClass) |
| TF subfamily | T3R (NR1A) {2.1.2.2} (TFClass) |
| TFClass ID | TFClass: 2.1.2.2.1 |
| HGNC | HGNC:11796 |
| MGI | MGI:98742 |
| EntrezGene (human) | GeneID:7067 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:21833 (SSTAR profile) |
| UniProt ID (human) | THA_HUMAN |
| UniProt ID (mouse) | THA_MOUSE |
| UniProt AC (human) | P10827 (TFClass) |
| UniProt AC (mouse) | P63058 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 1 human, 2 mouse |
| HT-SELEX | 2 |
| Methyl-HT-SELEX | 0 |
| PCM | THA.H12INVITRO.1.PS.A.pcm |
| PWM | THA.H12INVITRO.1.PS.A.pwm |
| PFM | THA.H12INVITRO.1.PS.A.pfm |
| Alignment | THA.H12INVITRO.1.PS.A.words.tsv |
| Threshold to P-value map | THA.H12INVITRO.1.PS.A.thr |
| Motif in other formats | |
| JASPAR format | THA.H12INVITRO.1.PS.A_jaspar_format.txt |
| MEME format | THA.H12INVITRO.1.PS.A_meme_format.meme |
| Transfac format | THA.H12INVITRO.1.PS.A_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 95.0 | 251.0 | 58.0 | 576.0 |
| 02 | 263.0 | 145.0 | 538.0 | 34.0 |
| 03 | 721.0 | 2.0 | 249.0 | 8.0 |
| 04 | 4.0 | 0.0 | 972.0 | 4.0 |
| 05 | 3.0 | 0.0 | 965.0 | 12.0 |
| 06 | 315.0 | 68.0 | 35.0 | 562.0 |
| 07 | 15.0 | 946.0 | 10.0 | 9.0 |
| 08 | 963.0 | 7.0 | 5.0 | 5.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.097 | 0.256 | 0.059 | 0.588 |
| 02 | 0.268 | 0.148 | 0.549 | 0.035 |
| 03 | 0.736 | 0.002 | 0.254 | 0.008 |
| 04 | 0.004 | 0.0 | 0.992 | 0.004 |
| 05 | 0.003 | 0.0 | 0.985 | 0.012 |
| 06 | 0.321 | 0.069 | 0.036 | 0.573 |
| 07 | 0.015 | 0.965 | 0.01 | 0.009 |
| 08 | 0.983 | 0.007 | 0.005 | 0.005 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.936 | 0.024 | -1.419 | 0.851 |
| 02 | 0.07 | -0.52 | 0.783 | -1.932 |
| 03 | 1.075 | -4.194 | 0.016 | -3.234 |
| 04 | -3.764 | -4.965 | 1.373 | -3.764 |
| 05 | -3.956 | -4.965 | 1.366 | -2.889 |
| 06 | 0.25 | -1.264 | -1.905 | 0.826 |
| 07 | -2.692 | 1.346 | -3.047 | -3.136 |
| 08 | 1.364 | -3.342 | -3.603 | -3.603 |
| P-value | Threshold |
|---|---|
| 0.001 | 4.722795 |
| 0.0005 | 5.96082 |
| 0.0001 | 7.635625 |