TFEC.H12RSNP.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TFEC.H12RSNP.1.SM.B
Gene (human)	TFEC (GeneCards)
Gene synonyms (human)	BHLHE34, TCFEC, TFECL
Gene (mouse)	Tfec
Gene synonyms (mouse)	Tcfec
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	13
Consensus	nnRGTCACGTGAY
GC content	51.91%
Information content (bits; total / per base)	17.939 / 1.38
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9113

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	1.0	0.999	0.998	0.997	0.996	0.995
Overall, 4 experiments	best	1.0	0.999	1.0	0.999	1.0	0.999
Methyl HT-SELEX, 2 experiments	median	1.0	0.999	0.997	0.996	0.994	0.992
Methyl HT-SELEX, 2 experiments	best	1.0	0.999	0.997	0.996	0.996	0.994
Non-Methyl HT-SELEX, 2 experiments	median	0.999	0.998	0.999	0.998	0.998	0.997
Non-Methyl HT-SELEX, 2 experiments	best	1.0	0.999	1.0	0.999	1.0	0.999

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.9	0.772	0.888	0.674

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	TFE3 {1.2.6.1} (TFClass)
TFClass ID	TFClass: 1.2.6.1.3
HGNC	HGNC:11754
MGI	MGI:1333760
EntrezGene (human)	GeneID:22797 (SSTAR profile)
EntrezGene (mouse)	GeneID:21426 (SSTAR profile)
UniProt ID (human)	TFEC_HUMAN
UniProt ID (mouse)	TFEC_MOUSE
UniProt AC (human)	O14948 (TFClass)
UniProt AC (mouse)	Q9WTW4 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	TFEC.H12RSNP.1.SM.B.pcm
PWM	TFEC.H12RSNP.1.SM.B.pwm
PFM	TFEC.H12RSNP.1.SM.B.pfm
Alignment	TFEC.H12RSNP.1.SM.B.words.tsv
Threshold to P-value map	TFEC.H12RSNP.1.SM.B.thr
Motif in other formats
JASPAR format	TFEC.H12RSNP.1.SM.B_jaspar_format.txt
MEME format	TFEC.H12RSNP.1.SM.B_meme_format.meme
Transfac format	TFEC.H12RSNP.1.SM.B_transfac_format.txt
Homer format	TFEC.H12RSNP.1.SM.B_homer_format_0.001.txt TFEC.H12RSNP.1.SM.B_homer_format_0.0005.txt TFEC.H12RSNP.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2028.5	2201.5	2591.5	2291.5
02	2953.75	1290.75	2359.75	2508.75
03	3104.0	346.0	4737.0	926.0
04	2258.0	2.0	6853.0	0.0
05	0.0	0.0	0.0	9113.0
06	0.0	9113.0	0.0	0.0
07	9113.0	0.0	0.0	0.0
08	0.0	9113.0	0.0	0.0
09	0.0	0.0	9113.0	0.0
10	0.0	0.0	0.0	9113.0
11	0.0	0.0	9113.0	0.0
12	8566.25	245.25	223.25	78.25
13	158.25	3651.25	549.25	4754.25

PFM

	A	C	G	T
01	0.223	0.242	0.284	0.251
02	0.324	0.142	0.259	0.275
03	0.341	0.038	0.52	0.102
04	0.248	0.0	0.752	0.0
05	0.0	0.0	0.0	1.0
06	0.0	1.0	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.0	1.0	0.0	0.0
09	0.0	0.0	1.0	0.0
10	0.0	0.0	0.0	1.0
11	0.0	0.0	1.0	0.0
12	0.94	0.027	0.024	0.009
13	0.017	0.401	0.06	0.522

PWM

	A	C	G	T
01	-0.116	-0.034	0.129	0.006
02	0.259	-0.567	0.035	0.096
03	0.309	-1.879	0.731	-0.899
04	-0.009	-6.278	1.101	-6.908
05	-6.908	-6.908	-6.908	1.386
06	-6.908	1.386	-6.908	-6.908
07	1.386	-6.908	-6.908	-6.908
08	-6.908	1.386	-6.908	-6.908
09	-6.908	-6.908	1.386	-6.908
10	-6.908	-6.908	-6.908	1.386
11	-6.908	-6.908	1.386	-6.908
12	1.324	-2.221	-2.314	-3.344
13	-2.654	0.471	-1.419	0.735

Standard thresholds

P-value	Threshold
0.001	-4.475705
0.0005	-2.18756
0.0001	2.63333