TFEC.H12CORE.0.M.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TFEC.H12CORE.0.M.B
Gene (human)	TFEC (GeneCards)
Gene synonyms (human)	BHLHE34, TCFEC, TFECL
Gene (mouse)	Tfec
Gene synonyms (mouse)	Tcfec
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	14
Consensus	ndvGTCACGTGAYn
GC content	51.88%
Information content (bits; total / per base)	16.701 / 1.193
Data sources	Methyl-HT-SELEX
Aligned words	9648

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	1.0	0.999	0.999	0.999	0.968	0.97
Overall, 4 experiments	best	1.0	0.999	1.0	0.999	0.997	0.996
Methyl HT-SELEX, 2 experiments	median	1.0	0.999	0.999	0.999	0.969	0.971
Methyl HT-SELEX, 2 experiments	best	1.0	0.999	1.0	0.999	0.997	0.996
Non-Methyl HT-SELEX, 2 experiments	median	0.999	0.998	0.998	0.997	0.968	0.969
Non-Methyl HT-SELEX, 2 experiments	best	1.0	0.999	0.999	0.998	0.995	0.993

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.853	0.601	0.831	0.638

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	TFE3 {1.2.6.1} (TFClass)
TFClass ID	TFClass: 1.2.6.1.3
HGNC	HGNC:11754
MGI	MGI:1333760
EntrezGene (human)	GeneID:22797 (SSTAR profile)
EntrezGene (mouse)	GeneID:21426 (SSTAR profile)
UniProt ID (human)	TFEC_HUMAN
UniProt ID (mouse)	TFEC_MOUSE
UniProt AC (human)	O14948 (TFClass)
UniProt AC (mouse)	Q9WTW4 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	TFEC.H12CORE.0.M.B.pcm
PWM	TFEC.H12CORE.0.M.B.pwm
PFM	TFEC.H12CORE.0.M.B.pfm
Alignment	TFEC.H12CORE.0.M.B.words.tsv
Threshold to P-value map	TFEC.H12CORE.0.M.B.thr
Motif in other formats
JASPAR format	TFEC.H12CORE.0.M.B_jaspar_format.txt
MEME format	TFEC.H12CORE.0.M.B_meme_format.meme
Transfac format	TFEC.H12CORE.0.M.B_transfac_format.txt
Homer format	TFEC.H12CORE.0.M.B_homer_format_0.001.txt TFEC.H12CORE.0.M.B_homer_format_0.0005.txt TFEC.H12CORE.0.M.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2264.0	2526.0	2790.0	2068.0
02	3480.25	1125.25	2933.25	2109.25
03	2303.0	1684.0	4651.0	1010.0
04	1270.0	3.0	8368.0	7.0
05	0.0	3.0	15.0	9630.0
06	0.0	9648.0	0.0	0.0
07	9647.0	1.0	0.0	0.0
08	0.0	8099.0	20.0	1529.0
09	977.0	1.0	8670.0	0.0
10	7.0	1.0	1.0	9639.0
11	1.0	1.0	9645.0	1.0
12	8740.0	324.0	406.0	178.0
13	118.0	3452.0	644.0	5434.0
14	2311.5	1802.5	3265.5	2268.5

PFM

	A	C	G	T
01	0.235	0.262	0.289	0.214
02	0.361	0.117	0.304	0.219
03	0.239	0.175	0.482	0.105
04	0.132	0.0	0.867	0.001
05	0.0	0.0	0.002	0.998
06	0.0	1.0	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.0	0.839	0.002	0.158
09	0.101	0.0	0.899	0.0
10	0.001	0.0	0.0	0.999
11	0.0	0.0	1.0	0.0
12	0.906	0.034	0.042	0.018
13	0.012	0.358	0.067	0.563
14	0.24	0.187	0.338	0.235

PWM

	A	C	G	T
01	-0.063	0.046	0.145	-0.154
02	0.366	-0.761	0.195	-0.134
03	-0.046	-0.359	0.656	-0.869
04	-0.641	-6.123	1.243	-5.56
05	-6.959	-6.123	-4.939	1.384
06	-6.959	1.386	-6.959	-6.959
07	1.385	-6.597	-6.959	-6.959
08	-6.959	1.211	-4.685	-0.455
09	-0.902	-6.597	1.279	-6.959
10	-5.56	-6.597	-6.597	1.385
11	-6.597	-6.597	1.385	-6.597
12	1.287	-2.001	-1.777	-2.595
13	-2.999	0.358	-1.318	0.812
14	-0.043	-0.291	0.303	-0.061

Standard thresholds

P-value	Threshold
0.001	-1.37504
0.0005	0.55286
0.0001	4.52117