TFEB.H12RSNP.1.P.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TFEB.H12RSNP.1.P.C
Gene (human)	TFEB (GeneCards)
Gene synonyms (human)	BHLHE35
Gene (mouse)	Tfeb
Gene synonyms (mouse)	Tcfeb
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	C

Motif length	9
Consensus	dGTCACGTG
GC content	57.57%
Information content (bits; total / per base)	15.296 / 1.7
Data sources	ChIP-Seq
Aligned words	259

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.553	0.557	0.451	0.46	0.8	0.805	2.522	2.581	174.328	182.745

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.999	0.998	0.998	0.996	0.98	0.971
Overall, 6 experiments	best	0.999	0.999	0.999	0.998	0.999	0.998
Methyl HT-SELEX, 2 experiments	median	0.998	0.996	0.988	0.985	0.98	0.971
Methyl HT-SELEX, 2 experiments	best	0.998	0.997	0.989	0.986	0.982	0.974
Non-Methyl HT-SELEX, 4 experiments	median	0.999	0.998	0.998	0.998	0.975	0.974
Non-Methyl HT-SELEX, 4 experiments	best	0.999	0.999	0.999	0.998	0.999	0.998

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.8	0.658	0.837	0.658

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	TFE3 {1.2.6.1} (TFClass)
TFClass ID	TFClass: 1.2.6.1.2
HGNC	HGNC:11753
MGI	MGI:103270
EntrezGene (human)	GeneID:7942 (SSTAR profile)
EntrezGene (mouse)	GeneID:21425 (SSTAR profile)
UniProt ID (human)	TFEB_HUMAN
UniProt ID (mouse)	TFEB_MOUSE
UniProt AC (human)	P19484 (TFClass)
UniProt AC (mouse)	Q9R210 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	TFEB.H12RSNP.1.P.C.pcm
PWM	TFEB.H12RSNP.1.P.C.pwm
PFM	TFEB.H12RSNP.1.P.C.pfm
Alignment	TFEB.H12RSNP.1.P.C.words.tsv
Threshold to P-value map	TFEB.H12RSNP.1.P.C.thr
Motif in other formats
JASPAR format	TFEB.H12RSNP.1.P.C_jaspar_format.txt
MEME format	TFEB.H12RSNP.1.P.C_meme_format.meme
Transfac format	TFEB.H12RSNP.1.P.C_transfac_format.txt
Homer format	TFEB.H12RSNP.1.P.C_homer_format_0.001.txt TFEB.H12RSNP.1.P.C_homer_format_0.0005.txt TFEB.H12RSNP.1.P.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	94.732	8.777	116.086	39.38
02	73.288	0.0	185.686	0.0
03	0.0	0.0	0.0	258.974
04	0.0	258.974	0.0	0.0
05	258.974	0.0	0.0	0.0
06	0.0	258.974	0.0	0.0
07	0.0	0.0	258.974	0.0
08	0.0	0.0	0.0	258.974
09	2.256	2.256	252.207	2.256

PFM

	A	C	G	T
01	0.366	0.034	0.448	0.152
02	0.283	0.0	0.717	0.0
03	0.0	0.0	0.0	1.0
04	0.0	1.0	0.0	0.0
05	1.0	0.0	0.0	0.0
06	0.0	1.0	0.0	0.0
07	0.0	0.0	1.0	0.0
08	0.0	0.0	0.0	1.0
09	0.009	0.009	0.974	0.009

PWM

	A	C	G	T
01	0.374	-1.873	0.575	-0.484
02	0.122	-3.863	1.04	-3.863
03	-3.863	-3.863	-3.863	1.37
04	-3.863	1.37	-3.863	-3.863
05	1.37	-3.863	-3.863	-3.863
06	-3.863	1.37	-3.863	-3.863
07	-3.863	-3.863	1.37	-3.863
08	-3.863	-3.863	-3.863	1.37
09	-2.898	-2.898	1.344	-2.898

Standard thresholds

P-value	Threshold
0.001	1.30832
0.0005	3.93462
0.0001	5.92155