TFEB.H12RSNP.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TFEB.H12RSNP.0.SM.B
Gene (human)	TFEB (GeneCards)
Gene synonyms (human)	BHLHE35
Gene (mouse)	Tfeb
Gene synonyms (mouse)	Tcfeb
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	18
Consensus	nnnnhRRTCACGTGAYhn
GC content	47.78%
Information content (bits; total / per base)	18.696 / 1.039
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	2325

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.576	0.578	0.486	0.493	0.762	0.766	2.306	2.348	146.921	162.886

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.999	0.999	0.998	0.997	0.991	0.988
Overall, 6 experiments	best	1.0	1.0	0.999	0.998	0.998	0.997
Methyl HT-SELEX, 2 experiments	median	0.999	0.999	0.997	0.996	0.994	0.991
Methyl HT-SELEX, 2 experiments	best	1.0	0.999	0.998	0.997	0.997	0.995
Non-Methyl HT-SELEX, 4 experiments	median	0.999	0.999	0.998	0.998	0.962	0.963
Non-Methyl HT-SELEX, 4 experiments	best	1.0	1.0	0.999	0.998	0.998	0.997

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.788	0.621	0.863	0.669

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	TFE3 {1.2.6.1} (TFClass)
TFClass ID	TFClass: 1.2.6.1.2
HGNC	HGNC:11753
MGI	MGI:103270
EntrezGene (human)	GeneID:7942 (SSTAR profile)
EntrezGene (mouse)	GeneID:21425 (SSTAR profile)
UniProt ID (human)	TFEB_HUMAN
UniProt ID (mouse)	TFEB_MOUSE
UniProt AC (human)	P19484 (TFClass)
UniProt AC (mouse)	Q9R210 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	TFEB.H12RSNP.0.SM.B.pcm
PWM	TFEB.H12RSNP.0.SM.B.pwm
PFM	TFEB.H12RSNP.0.SM.B.pfm
Alignment	TFEB.H12RSNP.0.SM.B.words.tsv
Threshold to P-value map	TFEB.H12RSNP.0.SM.B.thr
Motif in other formats
JASPAR format	TFEB.H12RSNP.0.SM.B_jaspar_format.txt
MEME format	TFEB.H12RSNP.0.SM.B_meme_format.meme
Transfac format	TFEB.H12RSNP.0.SM.B_transfac_format.txt
Homer format	TFEB.H12RSNP.0.SM.B_homer_format_0.001.txt TFEB.H12RSNP.0.SM.B_homer_format_0.0005.txt TFEB.H12RSNP.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	555.5	518.5	610.5	640.5
02	644.75	493.75	597.75	588.75
03	625.0	548.0	569.0	583.0
04	645.0	572.0	365.0	743.0
05	1009.0	296.0	260.0	760.0
06	1348.0	91.0	612.0	274.0
07	1035.0	5.0	1284.0	1.0
08	0.0	3.0	38.0	2284.0
09	0.0	2325.0	0.0	0.0
10	2325.0	0.0	0.0	0.0
11	0.0	2325.0	0.0	0.0
12	0.0	0.0	2325.0	0.0
13	0.0	0.0	0.0	2325.0
14	0.0	0.0	2325.0	0.0
15	2314.0	8.0	3.0	0.0
16	3.0	1354.0	22.0	946.0
17	481.0	956.0	302.0	586.0
18	653.0	832.0	357.0	483.0

PFM

	A	C	G	T
01	0.239	0.223	0.263	0.275
02	0.277	0.212	0.257	0.253
03	0.269	0.236	0.245	0.251
04	0.277	0.246	0.157	0.32
05	0.434	0.127	0.112	0.327
06	0.58	0.039	0.263	0.118
07	0.445	0.002	0.552	0.0
08	0.0	0.001	0.016	0.982
09	0.0	1.0	0.0	0.0
10	1.0	0.0	0.0	0.0
11	0.0	1.0	0.0	0.0
12	0.0	0.0	1.0	0.0
13	0.0	0.0	0.0	1.0
14	0.0	0.0	1.0	0.0
15	0.995	0.003	0.001	0.0
16	0.001	0.582	0.009	0.407
17	0.207	0.411	0.13	0.252
18	0.281	0.358	0.154	0.208

PWM

	A	C	G	T
01	-0.045	-0.114	0.049	0.097
02	0.103	-0.163	0.028	0.013
03	0.072	-0.059	-0.021	0.003
04	0.104	-0.016	-0.463	0.245
05	0.55	-0.672	-0.8	0.267
06	0.839	-1.837	0.051	-0.748
07	0.576	-4.432	0.791	-5.291
08	-5.707	-4.772	-2.681	1.366
09	-5.707	1.384	-5.707	-5.707
10	1.384	-5.707	-5.707	-5.707
11	-5.707	1.384	-5.707	-5.707
12	-5.707	-5.707	1.384	-5.707
13	-5.707	-5.707	-5.707	1.384
14	-5.707	-5.707	1.384	-5.707
15	1.379	-4.072	-4.772	-5.707
16	-4.772	0.844	-3.193	0.486
17	-0.189	0.496	-0.652	0.008
18	0.116	0.358	-0.485	-0.184

Standard thresholds

P-value	Threshold
0.001	-2.90564
0.0005	-1.10614
0.0001	3.07066