TFEB.H12INVITRO.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TFEB.H12INVITRO.0.SM.B
Gene (human)	TFEB (GeneCards)
Gene synonyms (human)	BHLHE35
Gene (mouse)	Tfeb
Gene synonyms (mouse)	Tcfeb
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	13
Consensus	nnRTCACGTGvbn
GC content	55.89%
Information content (bits; total / per base)	15.055 / 1.158
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9308

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.813	0.819	0.708	0.725	0.792	0.797	2.639	2.687	180.041	197.602

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.999	0.999	0.998	0.997	0.987	0.981
Overall, 6 experiments	best	1.0	1.0	0.999	0.999	0.999	0.998
Methyl HT-SELEX, 2 experiments	median	0.999	0.998	0.992	0.99	0.987	0.981
Methyl HT-SELEX, 2 experiments	best	0.999	0.999	0.992	0.99	0.988	0.983
Non-Methyl HT-SELEX, 4 experiments	median	0.999	0.999	0.999	0.998	0.976	0.975
Non-Methyl HT-SELEX, 4 experiments	best	1.0	1.0	0.999	0.999	0.999	0.998

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.786	0.621	0.831	0.633

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	TFE3 {1.2.6.1} (TFClass)
TFClass ID	TFClass: 1.2.6.1.2
HGNC	HGNC:11753
MGI	MGI:103270
EntrezGene (human)	GeneID:7942 (SSTAR profile)
EntrezGene (mouse)	GeneID:21425 (SSTAR profile)
UniProt ID (human)	TFEB_HUMAN
UniProt ID (mouse)	TFEB_MOUSE
UniProt AC (human)	P19484 (TFClass)
UniProt AC (mouse)	Q9R210 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	TFEB.H12INVITRO.0.SM.B.pcm
PWM	TFEB.H12INVITRO.0.SM.B.pwm
PFM	TFEB.H12INVITRO.0.SM.B.pfm
Alignment	TFEB.H12INVITRO.0.SM.B.words.tsv
Threshold to P-value map	TFEB.H12INVITRO.0.SM.B.thr
Motif in other formats
JASPAR format	TFEB.H12INVITRO.0.SM.B_jaspar_format.txt
MEME format	TFEB.H12INVITRO.0.SM.B_meme_format.meme
Transfac format	TFEB.H12INVITRO.0.SM.B_transfac_format.txt
Homer format	TFEB.H12INVITRO.0.SM.B_homer_format_0.001.txt TFEB.H12INVITRO.0.SM.B_homer_format_0.0005.txt TFEB.H12INVITRO.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2793.5	1642.5	2825.5	2046.5
02	1945.75	2302.75	3422.75	1636.75
03	2927.0	384.0	5950.0	47.0
04	0.0	2.0	39.0	9267.0
05	0.0	9308.0	0.0	0.0
06	9308.0	0.0	0.0	0.0
07	0.0	9307.0	0.0	1.0
08	0.0	0.0	9308.0	0.0
09	1.0	2.0	2.0	9303.0
10	6.0	0.0	9287.0	15.0
11	3323.0	2956.0	1964.0	1065.0
12	1298.0	2270.0	2142.0	3598.0
13	2209.25	2197.25	2323.25	2578.25

PFM

	A	C	G	T
01	0.3	0.176	0.304	0.22
02	0.209	0.247	0.368	0.176
03	0.314	0.041	0.639	0.005
04	0.0	0.0	0.004	0.996
05	0.0	1.0	0.0	0.0
06	1.0	0.0	0.0	0.0
07	0.0	1.0	0.0	0.0
08	0.0	0.0	1.0	0.0
09	0.0	0.0	0.0	0.999
10	0.001	0.0	0.998	0.002
11	0.357	0.318	0.211	0.114
12	0.139	0.244	0.23	0.387
13	0.237	0.236	0.25	0.277

PWM

	A	C	G	T
01	0.183	-0.348	0.194	-0.128
02	-0.179	-0.01	0.386	-0.351
03	0.229	-1.797	0.938	-3.856
04	-6.927	-6.298	-4.033	1.381
05	-6.927	1.386	-6.927	-6.927
06	1.386	-6.927	-6.927	-6.927
07	-6.927	1.385	-6.927	-6.564
08	-6.927	-6.927	1.386	-6.927
09	-6.564	-6.298	-6.298	1.385
10	-5.639	-6.927	1.383	-4.903
11	0.356	0.239	-0.169	-0.78
12	-0.583	-0.025	-0.083	0.435
13	-0.052	-0.057	-0.002	0.102

Standard thresholds

P-value	Threshold
0.001	-1.004555
0.0005	1.68599
0.0001	4.03736