TFE3.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TFE3.H12INVIVO.0.PSM.A
Gene (human)	TFE3 (GeneCards)
Gene synonyms (human)	BHLHE33
Gene (mouse)	Tfe3
Gene synonyms (mouse)	Tcfe3
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	11
Consensus	RGTCACGTGRY
GC content	54.83%
Information content (bits; total / per base)	15.848 / 1.441
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	1006

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.852	0.888	0.791	0.823	0.812	0.854	3.025	3.296	280.367	344.658
Mouse	9 (60)	0.995	0.999	0.99	0.999	0.995	1.0	7.896	8.616	655.321	1150.77

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.984	0.977	0.9	0.901	0.82	0.834
Overall, 4 experiments	best	0.997	0.995	0.996	0.993	0.992	0.988
Methyl HT-SELEX, 1 experiments	median	0.997	0.995	0.996	0.993	0.992	0.988
Methyl HT-SELEX, 1 experiments	best	0.997	0.995	0.996	0.993	0.992	0.988
Non-Methyl HT-SELEX, 3 experiments	median	0.973	0.965	0.808	0.817	0.653	0.689
Non-Methyl HT-SELEX, 3 experiments	best	0.994	0.989	0.992	0.986	0.987	0.979

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.92	0.577	0.93	0.597
batch 2	0.668	0.393	0.671	0.454

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	TFE3 {1.2.6.1} (TFClass)
TFClass ID	TFClass: 1.2.6.1.1
HGNC	HGNC:11752
MGI	MGI:98511
EntrezGene (human)	GeneID:7030 (SSTAR profile)
EntrezGene (mouse)	GeneID:209446 (SSTAR profile)
UniProt ID (human)	TFE3_HUMAN
UniProt ID (mouse)	TFE3_MOUSE
UniProt AC (human)	P19532 (TFClass)
UniProt AC (mouse)	Q64092 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 9 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	TFE3.H12INVIVO.0.PSM.A.pcm
PWM	TFE3.H12INVIVO.0.PSM.A.pwm
PFM	TFE3.H12INVIVO.0.PSM.A.pfm
Alignment	TFE3.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	TFE3.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	TFE3.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	TFE3.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	TFE3.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	TFE3.H12INVIVO.0.PSM.A_homer_format_0.001.txt TFE3.H12INVIVO.0.PSM.A_homer_format_0.0005.txt TFE3.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	317.0	31.0	510.0	148.0
02	105.0	3.0	894.0	4.0
03	0.0	4.0	11.0	991.0
04	0.0	1005.0	1.0	0.0
05	998.0	4.0	2.0	2.0
06	0.0	953.0	10.0	43.0
07	109.0	4.0	893.0	0.0
08	32.0	3.0	9.0	962.0
09	1.0	0.0	1005.0	0.0
10	778.0	74.0	121.0	33.0
11	23.0	414.0	116.0	453.0

PFM

	A	C	G	T
01	0.315	0.031	0.507	0.147
02	0.104	0.003	0.889	0.004
03	0.0	0.004	0.011	0.985
04	0.0	0.999	0.001	0.0
05	0.992	0.004	0.002	0.002
06	0.0	0.947	0.01	0.043
07	0.108	0.004	0.888	0.0
08	0.032	0.003	0.009	0.956
09	0.001	0.0	0.999	0.0
10	0.773	0.074	0.12	0.033
11	0.023	0.412	0.115	0.45

PWM

	A	C	G	T
01	0.23	-2.046	0.704	-0.525
02	-0.864	-3.981	1.263	-3.789
03	-4.987	-3.789	-2.99	1.366
04	-4.987	1.38	-4.531	-4.987
05	1.373	-3.789	-4.218	-4.218
06	-4.987	1.327	-3.072	-1.734
07	-0.827	-3.789	1.262	-4.987
08	-2.016	-3.981	-3.161	1.337
09	-4.531	-4.987	1.38	-4.987
10	1.125	-1.207	-0.724	-1.987
11	-2.326	0.496	-0.766	0.585

Standard thresholds

P-value	Threshold
0.001	1.667425
0.0005	3.102605
0.0001	6.084515