TFE2.H12INVITRO.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TFE2.H12INVITRO.0.PS.A
Gene (human)	TCF3 (GeneCards)
Gene synonyms (human)	BHLHB21, E2A, ITF1
Gene (mouse)	Tcf3
Gene synonyms (mouse)	Alf2, Me2, Tcfe2a
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	14
Consensus	nnnhRCACCTGbnn
GC content	56.28%
Information content (bits; total / per base)	13.334 / 0.952
Data sources	ChIP-Seq + HT-SELEX
Aligned words	9390

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	8 (48)	0.786	0.897	0.624	0.761	0.763	0.888	2.045	2.849	60.987	149.77
Mouse	23 (149)	0.869	0.929	0.72	0.829	0.815	0.89	2.317	2.828	142.0	267.678

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	0.997	0.995	0.996	0.993	0.969	0.967
Non-Methyl HT-SELEX, 2 experiments	best	0.998	0.996	0.997	0.995	0.983	0.981

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	E2A {1.2.1} (TFClass)
TF subfamily	E2A-like {1.2.1.0} (TFClass)
TFClass ID	TFClass: 1.2.1.0.1
HGNC	HGNC:11633
MGI	MGI:98510
EntrezGene (human)	GeneID:6929 (SSTAR profile)
EntrezGene (mouse)	GeneID:21423 (SSTAR profile)
UniProt ID (human)	TFE2_HUMAN
UniProt ID (mouse)	TFE2_MOUSE
UniProt AC (human)	P15923 (TFClass)
UniProt AC (mouse)	P15806 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	8 human, 23 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	TFE2.H12INVITRO.0.PS.A.pcm
PWM	TFE2.H12INVITRO.0.PS.A.pwm
PFM	TFE2.H12INVITRO.0.PS.A.pfm
Alignment	TFE2.H12INVITRO.0.PS.A.words.tsv
Threshold to P-value map	TFE2.H12INVITRO.0.PS.A.thr
Motif in other formats
JASPAR format	TFE2.H12INVITRO.0.PS.A_jaspar_format.txt
MEME format	TFE2.H12INVITRO.0.PS.A_meme_format.meme
Transfac format	TFE2.H12INVITRO.0.PS.A_transfac_format.txt
Homer format	TFE2.H12INVITRO.0.PS.A_homer_format_0.001.txt TFE2.H12INVITRO.0.PS.A_homer_format_0.0005.txt TFE2.H12INVITRO.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2336.25	1874.25	2931.25	2248.25
02	2067.5	1940.5	2843.5	2538.5
03	2120.0	1522.0	3199.0	2549.0
04	4193.0	2408.0	730.0	2059.0
05	5211.0	554.0	3520.0	105.0
06	4.0	9386.0	0.0	0.0
07	9390.0	0.0	0.0	0.0
08	0.0	9323.0	64.0	3.0
09	0.0	9382.0	8.0	0.0
10	0.0	0.0	0.0	9390.0
11	0.0	1.0	9389.0	0.0
12	138.0	3986.0	2118.0	3148.0
13	2318.25	1603.25	2365.25	3103.25
14	2393.0	2998.0	1834.0	2165.0

PFM

	A	C	G	T
01	0.249	0.2	0.312	0.239
02	0.22	0.207	0.303	0.27
03	0.226	0.162	0.341	0.271
04	0.447	0.256	0.078	0.219
05	0.555	0.059	0.375	0.011
06	0.0	1.0	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.0	0.993	0.007	0.0
09	0.0	0.999	0.001	0.0
10	0.0	0.0	0.0	1.0
11	0.0	0.0	1.0	0.0
12	0.015	0.424	0.226	0.335
13	0.247	0.171	0.252	0.33
14	0.255	0.319	0.195	0.231

PWM

	A	C	G	T
01	-0.005	-0.225	0.222	-0.043
02	-0.127	-0.19	0.192	0.078
03	-0.102	-0.433	0.309	0.082
04	0.58	0.025	-1.166	-0.131
05	0.797	-1.441	0.405	-3.087
06	-5.924	1.385	-6.935	-6.935
07	1.386	-6.935	-6.935	-6.935
08	-6.935	1.378	-3.568	-6.097
09	-6.935	1.385	-5.431	-6.935
10	-6.935	-6.935	-6.935	1.386
11	-6.935	-6.572	1.385	-6.935
12	-2.818	0.529	-0.103	0.293
13	-0.013	-0.381	0.008	0.279
14	0.019	0.244	-0.247	-0.081

Standard thresholds

P-value	Threshold
0.001	1.06151
0.0005	1.99931
0.0001	7.37522