TFE2.H12CORE.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TFE2.H12CORE.0.PS.A
Gene (human)	TCF3 (GeneCards)
Gene synonyms (human)	BHLHB21, E2A, ITF1
Gene (mouse)	Tcf3
Gene synonyms (mouse)	Alf2, Me2, Tcfe2a
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	10
Consensus	nvCASCTGSn
GC content	63.3%
Information content (bits; total / per base)	11.432 / 1.143
Data sources	ChIP-Seq + HT-SELEX
Aligned words	999

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	8 (48)	0.828	0.917	0.709	0.855	0.787	0.891	2.174	2.846	86.641	179.585
Mouse	23 (149)	0.903	0.954	0.798	0.896	0.846	0.894	2.442	2.798	187.854	343.42

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	0.997	0.995	0.994	0.991	0.971	0.968
Non-Methyl HT-SELEX, 2 experiments	best	0.998	0.997	0.996	0.993	0.985	0.981

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	E2A {1.2.1} (TFClass)
TF subfamily	E2A-like {1.2.1.0} (TFClass)
TFClass ID	TFClass: 1.2.1.0.1
HGNC	HGNC:11633
MGI	MGI:98510
EntrezGene (human)	GeneID:6929 (SSTAR profile)
EntrezGene (mouse)	GeneID:21423 (SSTAR profile)
UniProt ID (human)	TFE2_HUMAN
UniProt ID (mouse)	TFE2_MOUSE
UniProt AC (human)	P15923 (TFClass)
UniProt AC (mouse)	P15806 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	8 human, 23 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	TFE2.H12CORE.0.PS.A.pcm
PWM	TFE2.H12CORE.0.PS.A.pwm
PFM	TFE2.H12CORE.0.PS.A.pfm
Alignment	TFE2.H12CORE.0.PS.A.words.tsv
Threshold to P-value map	TFE2.H12CORE.0.PS.A.thr
Motif in other formats
JASPAR format	TFE2.H12CORE.0.PS.A_jaspar_format.txt
MEME format	TFE2.H12CORE.0.PS.A_meme_format.meme
Transfac format	TFE2.H12CORE.0.PS.A_transfac_format.txt
Homer format	TFE2.H12CORE.0.PS.A_homer_format_0.001.txt TFE2.H12CORE.0.PS.A_homer_format_0.0005.txt TFE2.H12CORE.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	315.0	309.0	224.0	151.0
02	417.0	249.0	305.0	28.0
03	2.0	994.0	1.0	2.0
04	989.0	0.0	5.0	5.0
05	1.0	671.0	275.0	52.0
06	3.0	993.0	2.0	1.0
07	0.0	3.0	2.0	994.0
08	1.0	1.0	993.0	4.0
09	7.0	543.0	243.0	206.0
10	284.0	257.0	254.0	204.0

PFM

	A	C	G	T
01	0.315	0.309	0.224	0.151
02	0.417	0.249	0.305	0.028
03	0.002	0.995	0.001	0.002
04	0.99	0.0	0.005	0.005
05	0.001	0.672	0.275	0.052
06	0.003	0.994	0.002	0.001
07	0.0	0.003	0.002	0.995
08	0.001	0.001	0.994	0.004
09	0.007	0.544	0.243	0.206
10	0.284	0.257	0.254	0.204

PWM

	A	C	G	T
01	0.231	0.212	-0.108	-0.499
02	0.51	-0.003	0.199	-2.135
03	-4.212	1.376	-4.524	-4.212
04	1.371	-4.981	-3.621	-3.621
05	-4.524	0.984	0.096	-1.543
06	-3.974	1.375	-4.212	-4.524
07	-4.981	-3.974	-4.212	1.376
08	-4.524	-4.524	1.375	-3.782
09	-3.361	0.773	-0.027	-0.191
10	0.128	0.028	0.017	-0.201

Standard thresholds

P-value	Threshold
0.001	3.27893
0.0005	4.76615
0.0001	8.0644