MotifTF7L1.H12INVIVO.1.P.C
Gene (human)TCF7L1
(GeneCards)
Gene synonyms (human)TCF3
Gene (mouse)Tcf7l1
Gene synonyms (mouse)Tcf3
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
C
Motif length12
ConsensusCTTTGWWvTKbd
GC content34.44%
Information content (bits; total / per base)11.64 / 0.97
Data sourcesChIP-Seq
Aligned words1004

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 1 (7) 0.672 0.682 0.532 0.55 0.708 0.711 1.982 2.046 51.222 62.432
Mouse 1 (7) 0.846 0.85 0.765 0.775 0.847 0.854 3.388 3.455 148.222 165.538

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 2 experiments median 0.677 0.664 0.574 0.586 0.52 0.544
best 0.745 0.712 0.622 0.621 0.545 0.566
Methyl HT-SELEX, 1 experiments median 0.61 0.616 0.525 0.55 0.494 0.521
best 0.61 0.616 0.525 0.55 0.494 0.521
Non-Methyl HT-SELEX, 1 experiments median 0.745 0.712 0.622 0.621 0.545 0.566
best 0.745 0.712 0.622 0.621 0.545 0.566
TF superclassOther all-alpha-helical DNA-binding domains {4} (TFClass)
TF classHigh-mobility group (HMG) domain factors {4.1} (TFClass)
TF familyTCF7-related {4.1.3} (TFClass)
TF subfamily {4.1.3.0} (TFClass)
TFClass IDTFClass: 4.1.3.0.2
HGNCHGNC:11640
MGIMGI:1202876
EntrezGene (human)GeneID:83439
(SSTAR profile)
EntrezGene (mouse)GeneID:21415
(SSTAR profile)
UniProt ID (human)TF7L1_HUMAN
UniProt ID (mouse)TF7L1_MOUSE
UniProt AC (human)Q9HCS4
(TFClass)
UniProt AC (mouse)Q9Z1J1
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 1 human, 1 mouse
HT-SELEX 1
Methyl-HT-SELEX 1
PCM
ACGT
0111.0856.027.0110.0
0278.022.02.0902.0
030.041.016.0947.0
0415.01.014.0974.0
0515.0131.0808.050.0
06686.032.056.0230.0
07351.060.076.0517.0
08551.0175.0216.062.0
0943.023.021.0917.0
1032.083.0710.0179.0
1159.0498.0127.0320.0
12470.073.081.0380.0
PFM
ACGT
010.0110.8530.0270.11
020.0780.0220.0020.898
030.00.0410.0160.943
040.0150.0010.0140.97
050.0150.130.8050.05
060.6830.0320.0560.229
070.350.060.0760.515
080.5490.1740.2150.062
090.0430.0230.0210.913
100.0320.0830.7070.178
110.0590.4960.1260.319
120.4680.0730.0810.378
PWM
ACGT
01-2.9891.222-2.174-0.816
02-1.154-2.366-4.2161.274
03-4.985-1.777-2.6571.323
04-2.715-4.529-2.7771.351
05-2.715-0.6441.164-1.586
061.001-2.014-1.477-0.087
070.333-1.41-1.1790.719
080.783-0.358-0.149-1.378
09-1.732-2.324-2.4091.291
10-2.014-1.0931.035-0.335
11-1.4260.682-0.6750.241
120.624-1.218-1.1170.412
Standard thresholds
P-value Threshold
0.001 4.299915
0.0005 5.242465
0.0001 7.188115