TF7L1.H12INVITRO.0.PM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TF7L1.H12INVITRO.0.PM.A
Gene (human)	TCF7L1 (GeneCards)
Gene synonyms (human)	TCF3
Gene (mouse)	Tcf7l1
Gene synonyms (mouse)	Tcf3
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	17
Consensus	nhhnbbCTTTGATSYhn
GC content	47.33%
Information content (bits; total / per base)	13.882 / 0.817
Data sources	ChIP-Seq + Methyl-HT-SELEX
Aligned words	1130

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.738	0.755	0.633	0.65	0.724	0.73	2.133	2.174	88.018	101.276
Mouse	1 (7)	0.695	0.7	0.557	0.571	0.686	0.687	1.839	1.871	65.886	71.745

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.811	0.793	0.695	0.686	0.609	0.617
Overall, 2 experiments	best	0.881	0.857	0.751	0.737	0.645	0.651
Methyl HT-SELEX, 1 experiments	median	0.742	0.729	0.638	0.635	0.574	0.582
Methyl HT-SELEX, 1 experiments	best	0.742	0.729	0.638	0.635	0.574	0.582
Non-Methyl HT-SELEX, 1 experiments	median	0.881	0.857	0.751	0.737	0.645	0.651
Non-Methyl HT-SELEX, 1 experiments	best	0.881	0.857	0.751	0.737	0.645	0.651

TF superclass	Other all-alpha-helical DNA-binding domains {4} (TFClass)
TF class	High-mobility group (HMG) domain factors {4.1} (TFClass)
TF family	TCF7-related {4.1.3} (TFClass)
TF subfamily	{4.1.3.0} (TFClass)
TFClass ID	TFClass: 4.1.3.0.2
HGNC	HGNC:11640
MGI	MGI:1202876
EntrezGene (human)	GeneID:83439 (SSTAR profile)
EntrezGene (mouse)	GeneID:21415 (SSTAR profile)
UniProt ID (human)	TF7L1_HUMAN
UniProt ID (mouse)	TF7L1_MOUSE
UniProt AC (human)	Q9HCS4 (TFClass)
UniProt AC (mouse)	Q9Z1J1 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 1 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	TF7L1.H12INVITRO.0.PM.A.pcm
PWM	TF7L1.H12INVITRO.0.PM.A.pwm
PFM	TF7L1.H12INVITRO.0.PM.A.pfm
Alignment	TF7L1.H12INVITRO.0.PM.A.words.tsv
Threshold to P-value map	TF7L1.H12INVITRO.0.PM.A.thr
Motif in other formats
JASPAR format	TF7L1.H12INVITRO.0.PM.A_jaspar_format.txt
MEME format	TF7L1.H12INVITRO.0.PM.A_meme_format.meme
Transfac format	TF7L1.H12INVITRO.0.PM.A_transfac_format.txt
Homer format	TF7L1.H12INVITRO.0.PM.A_homer_format_0.001.txt TF7L1.H12INVITRO.0.PM.A_homer_format_0.0005.txt TF7L1.H12INVITRO.0.PM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	391.5	254.5	209.5	274.5
02	247.5	480.5	175.5	226.5
03	456.0	255.0	184.0	235.0
04	225.0	276.0	349.0	280.0
05	147.0	573.0	159.0	251.0
06	98.0	522.0	409.0	101.0
07	2.0	1080.0	14.0	34.0
08	0.0	229.0	0.0	901.0
09	0.0	16.0	0.0	1114.0
10	0.0	248.0	0.0	882.0
11	0.0	81.0	1049.0	0.0
12	1057.0	73.0	0.0	0.0
13	2.0	0.0	0.0	1128.0
14	7.0	565.0	556.0	2.0
15	120.0	264.0	27.0	719.0
16	214.25	305.25	161.25	449.25
17	243.5	347.5	229.5	309.5

PFM

	A	C	G	T
01	0.346	0.225	0.185	0.243
02	0.219	0.425	0.155	0.2
03	0.404	0.226	0.163	0.208
04	0.199	0.244	0.309	0.248
05	0.13	0.507	0.141	0.222
06	0.087	0.462	0.362	0.089
07	0.002	0.956	0.012	0.03
08	0.0	0.203	0.0	0.797
09	0.0	0.014	0.0	0.986
10	0.0	0.219	0.0	0.781
11	0.0	0.072	0.928	0.0
12	0.935	0.065	0.0	0.0
13	0.002	0.0	0.0	0.998
14	0.006	0.5	0.492	0.002
15	0.106	0.234	0.024	0.636
16	0.19	0.27	0.143	0.398
17	0.215	0.308	0.203	0.274

PWM

	A	C	G	T
01	0.325	-0.104	-0.297	-0.029
02	-0.131	0.529	-0.472	-0.219
03	0.476	-0.102	-0.425	-0.183
04	-0.226	-0.023	0.21	-0.009
05	-0.648	0.704	-0.57	-0.117
06	-1.047	0.611	0.368	-1.018
07	-4.326	1.336	-2.893	-2.073
08	-5.086	-0.209	-5.086	1.156
09	-5.086	-2.773	-5.086	1.367
10	-5.086	-0.129	-5.086	1.134
11	-5.086	-1.234	1.307	-5.086
12	1.315	-1.336	-5.086	-5.086
13	-4.326	-5.086	-5.086	1.38
14	-3.48	0.69	0.674	-4.326
15	-0.848	-0.067	-2.291	0.93
16	-0.275	0.077	-0.556	0.462
17	-0.148	0.206	-0.206	0.091

Standard thresholds

P-value	Threshold
0.001	2.86296
0.0005	4.17136
0.0001	6.96266