TF7L1.H12CORE.1.P.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TF7L1.H12CORE.1.P.C
Gene (human)	TCF7L1 (GeneCards)
Gene synonyms (human)	TCF3
Gene (mouse)	Tcf7l1
Gene synonyms (mouse)	Tcf3
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	C

Motif length	12
Consensus	CTTTGWWvTKbd
GC content	34.44%
Information content (bits; total / per base)	11.64 / 0.97
Data sources	ChIP-Seq
Aligned words	1004

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.672	0.682	0.532	0.55	0.708	0.711	1.982	2.046	51.222	62.432
Mouse	1 (7)	0.846	0.85	0.765	0.775	0.847	0.854	3.388	3.455	148.222	165.538

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.677	0.664	0.574	0.586	0.52	0.544
Overall, 2 experiments	best	0.745	0.712	0.622	0.621	0.545	0.566
Methyl HT-SELEX, 1 experiments	median	0.61	0.616	0.525	0.55	0.494	0.521
Methyl HT-SELEX, 1 experiments	best	0.61	0.616	0.525	0.55	0.494	0.521
Non-Methyl HT-SELEX, 1 experiments	median	0.745	0.712	0.622	0.621	0.545	0.566
Non-Methyl HT-SELEX, 1 experiments	best	0.745	0.712	0.622	0.621	0.545	0.566

TF superclass	Other all-alpha-helical DNA-binding domains {4} (TFClass)
TF class	High-mobility group (HMG) domain factors {4.1} (TFClass)
TF family	TCF7-related {4.1.3} (TFClass)
TF subfamily	{4.1.3.0} (TFClass)
TFClass ID	TFClass: 4.1.3.0.2
HGNC	HGNC:11640
MGI	MGI:1202876
EntrezGene (human)	GeneID:83439 (SSTAR profile)
EntrezGene (mouse)	GeneID:21415 (SSTAR profile)
UniProt ID (human)	TF7L1_HUMAN
UniProt ID (mouse)	TF7L1_MOUSE
UniProt AC (human)	Q9HCS4 (TFClass)
UniProt AC (mouse)	Q9Z1J1 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 1 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	TF7L1.H12CORE.1.P.C.pcm
PWM	TF7L1.H12CORE.1.P.C.pwm
PFM	TF7L1.H12CORE.1.P.C.pfm
Alignment	TF7L1.H12CORE.1.P.C.words.tsv
Threshold to P-value map	TF7L1.H12CORE.1.P.C.thr
Motif in other formats
JASPAR format	TF7L1.H12CORE.1.P.C_jaspar_format.txt
MEME format	TF7L1.H12CORE.1.P.C_meme_format.meme
Transfac format	TF7L1.H12CORE.1.P.C_transfac_format.txt
Homer format	TF7L1.H12CORE.1.P.C_homer_format_0.001.txt TF7L1.H12CORE.1.P.C_homer_format_0.0005.txt TF7L1.H12CORE.1.P.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	11.0	856.0	27.0	110.0
02	78.0	22.0	2.0	902.0
03	0.0	41.0	16.0	947.0
04	15.0	1.0	14.0	974.0
05	15.0	131.0	808.0	50.0
06	686.0	32.0	56.0	230.0
07	351.0	60.0	76.0	517.0
08	551.0	175.0	216.0	62.0
09	43.0	23.0	21.0	917.0
10	32.0	83.0	710.0	179.0
11	59.0	498.0	127.0	320.0
12	470.0	73.0	81.0	380.0

PFM

	A	C	G	T
01	0.011	0.853	0.027	0.11
02	0.078	0.022	0.002	0.898
03	0.0	0.041	0.016	0.943
04	0.015	0.001	0.014	0.97
05	0.015	0.13	0.805	0.05
06	0.683	0.032	0.056	0.229
07	0.35	0.06	0.076	0.515
08	0.549	0.174	0.215	0.062
09	0.043	0.023	0.021	0.913
10	0.032	0.083	0.707	0.178
11	0.059	0.496	0.126	0.319
12	0.468	0.073	0.081	0.378

PWM

	A	C	G	T
01	-2.989	1.222	-2.174	-0.816
02	-1.154	-2.366	-4.216	1.274
03	-4.985	-1.777	-2.657	1.323
04	-2.715	-4.529	-2.777	1.351
05	-2.715	-0.644	1.164	-1.586
06	1.001	-2.014	-1.477	-0.087
07	0.333	-1.41	-1.179	0.719
08	0.783	-0.358	-0.149	-1.378
09	-1.732	-2.324	-2.409	1.291
10	-2.014	-1.093	1.035	-0.335
11	-1.426	0.682	-0.675	0.241
12	0.624	-1.218	-1.117	0.412

Standard thresholds

P-value	Threshold
0.001	4.299915
0.0005	5.242465
0.0001	7.188115