TF7L1.H12CORE.0.PM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TF7L1.H12CORE.0.PM.A
Gene (human)	TCF7L1 (GeneCards)
Gene synonyms (human)	TCF3
Gene (mouse)	Tcf7l1
Gene synonyms (mouse)	Tcf3
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	12
Consensus	nbCTTTSAWSWb
GC content	39.27%
Information content (bits; total / per base)	10.895 / 0.908
Data sources	ChIP-Seq + Methyl-HT-SELEX
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.833	0.849	0.737	0.769	0.815	0.826	2.707	2.788	135.42	158.745
Mouse	1 (7)	0.817	0.817	0.7	0.707	0.803	0.805	2.483	2.521	129.027	138.046

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.744	0.754	0.592	0.628	0.521	0.564
Overall, 2 experiments	best	0.857	0.842	0.667	0.689	0.556	0.6
Methyl HT-SELEX, 1 experiments	median	0.63	0.667	0.517	0.567	0.486	0.527
Methyl HT-SELEX, 1 experiments	best	0.63	0.667	0.517	0.567	0.486	0.527
Non-Methyl HT-SELEX, 1 experiments	median	0.857	0.842	0.667	0.689	0.556	0.6
Non-Methyl HT-SELEX, 1 experiments	best	0.857	0.842	0.667	0.689	0.556	0.6

TF superclass	Other all-alpha-helical DNA-binding domains {4} (TFClass)
TF class	High-mobility group (HMG) domain factors {4.1} (TFClass)
TF family	TCF7-related {4.1.3} (TFClass)
TF subfamily	{4.1.3.0} (TFClass)
TFClass ID	TFClass: 4.1.3.0.2
HGNC	HGNC:11640
MGI	MGI:1202876
EntrezGene (human)	GeneID:83439 (SSTAR profile)
EntrezGene (mouse)	GeneID:21415 (SSTAR profile)
UniProt ID (human)	TF7L1_HUMAN
UniProt ID (mouse)	TF7L1_MOUSE
UniProt AC (human)	Q9HCS4 (TFClass)
UniProt AC (mouse)	Q9Z1J1 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 1 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	TF7L1.H12CORE.0.PM.A.pcm
PWM	TF7L1.H12CORE.0.PM.A.pwm
PFM	TF7L1.H12CORE.0.PM.A.pfm
Alignment	TF7L1.H12CORE.0.PM.A.words.tsv
Threshold to P-value map	TF7L1.H12CORE.0.PM.A.thr
Motif in other formats
JASPAR format	TF7L1.H12CORE.0.PM.A_jaspar_format.txt
MEME format	TF7L1.H12CORE.0.PM.A_meme_format.meme
Transfac format	TF7L1.H12CORE.0.PM.A_transfac_format.txt
Homer format	TF7L1.H12CORE.0.PM.A_homer_format_0.001.txt TF7L1.H12CORE.0.PM.A_homer_format_0.0005.txt TF7L1.H12CORE.0.PM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	120.0	294.0	278.0	308.0
02	94.0	406.0	230.0	270.0
03	11.0	810.0	38.0	141.0
04	6.0	16.0	2.0	976.0
05	2.0	51.0	14.0	933.0
06	13.0	4.0	8.0	975.0
07	44.0	137.0	768.0	51.0
08	867.0	15.0	9.0	109.0
09	325.0	4.0	18.0	653.0
10	73.0	403.0	481.0	43.0
11	154.0	134.0	43.0	669.0
12	100.0	282.0	267.0	351.0

PFM

	A	C	G	T
01	0.12	0.294	0.278	0.308
02	0.094	0.406	0.23	0.27
03	0.011	0.81	0.038	0.141
04	0.006	0.016	0.002	0.976
05	0.002	0.051	0.014	0.933
06	0.013	0.004	0.008	0.975
07	0.044	0.137	0.768	0.051
08	0.867	0.015	0.009	0.109
09	0.325	0.004	0.018	0.653
10	0.073	0.403	0.481	0.043
11	0.154	0.134	0.043	0.669
12	0.1	0.282	0.267	0.351

PWM

	A	C	G	T
01	-0.727	0.161	0.105	0.207
02	-0.967	0.482	-0.083	0.076
03	-2.985	1.171	-1.846	-0.567
04	-3.484	-2.653	-4.213	1.357
05	-4.213	-1.563	-2.773	1.312
06	-2.839	-3.783	-3.253	1.356
07	-1.706	-0.596	1.118	-1.563
08	1.239	-2.711	-3.156	-0.821
09	0.261	-3.783	-2.546	0.956
10	-1.215	0.475	0.651	-1.728
11	-0.48	-0.618	-1.728	0.98
12	-0.906	0.12	0.065	0.337

Standard thresholds

P-value	Threshold
0.001	4.501665
0.0005	5.4473
0.0001	7.350455