TEAD4.H12INVITRO.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TEAD4.H12INVITRO.1.P.B
Gene (human)	TEAD4 (GeneCards)
Gene synonyms (human)	RTEF1, TCF13L1, TEF3
Gene (mouse)	Tead4
Gene synonyms (mouse)	Tcf13r1, Tef3, Tefr1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	16
Consensus	RMATTCCWnvvMKdbb
GC content	45.85%
Information content (bits; total / per base)	13.003 / 0.813
Data sources	ChIP-Seq
Aligned words	999

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	27 (163)	0.83	0.944	0.736	0.892	0.82	0.933	2.917	4.55	208.367	583.721
Mouse	17 (104)	0.877	0.955	0.777	0.917	0.846	0.939	3.175	4.606	191.28	441.721

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	0.832	0.798	0.717	0.699	0.622	0.626
Non-Methyl HT-SELEX, 2 experiments	best	0.895	0.868	0.767	0.751	0.654	0.661

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	7.711	14.217	0.122	0.037

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	TEA domain factors {3.6} (TFClass)
TF family	TEF1-related {3.6.1} (TFClass)
TF subfamily	{3.6.1.0} (TFClass)
TFClass ID	TFClass: 3.6.1.0.2
HGNC	HGNC:11717
MGI	MGI:106907
EntrezGene (human)	GeneID:7004 (SSTAR profile)
EntrezGene (mouse)	GeneID:21679 (SSTAR profile)
UniProt ID (human)	TEAD4_HUMAN
UniProt ID (mouse)	TEAD4_MOUSE
UniProt AC (human)	Q15561 (TFClass)
UniProt AC (mouse)	Q62296 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	27 human, 17 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	TEAD4.H12INVITRO.1.P.B.pcm
PWM	TEAD4.H12INVITRO.1.P.B.pwm
PFM	TEAD4.H12INVITRO.1.P.B.pfm
Alignment	TEAD4.H12INVITRO.1.P.B.words.tsv
Threshold to P-value map	TEAD4.H12INVITRO.1.P.B.thr
Motif in other formats
JASPAR format	TEAD4.H12INVITRO.1.P.B_jaspar_format.txt
MEME format	TEAD4.H12INVITRO.1.P.B_meme_format.meme
Transfac format	TEAD4.H12INVITRO.1.P.B_transfac_format.txt
Homer format	TEAD4.H12INVITRO.1.P.B_homer_format_0.001.txt TEAD4.H12INVITRO.1.P.B_homer_format_0.0005.txt TEAD4.H12INVITRO.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	537.0	11.0	417.0	34.0
02	252.0	617.0	130.0	0.0
03	991.0	0.0	7.0	1.0
04	0.0	1.0	2.0	996.0
05	71.0	2.0	79.0	847.0
06	2.0	957.0	23.0	17.0
07	5.0	847.0	0.0	147.0
08	361.0	57.0	32.0	549.0
09	169.0	116.0	598.0	116.0
10	251.0	142.0	501.0	105.0
11	283.0	467.0	217.0	32.0
12	663.0	127.0	97.0	112.0
13	87.0	113.0	119.0	680.0
14	238.0	111.0	241.0	409.0
15	89.0	513.0	188.0	209.0
16	101.0	471.0	126.0	301.0

PFM

	A	C	G	T
01	0.538	0.011	0.417	0.034
02	0.252	0.618	0.13	0.0
03	0.992	0.0	0.007	0.001
04	0.0	0.001	0.002	0.997
05	0.071	0.002	0.079	0.848
06	0.002	0.958	0.023	0.017
07	0.005	0.848	0.0	0.147
08	0.361	0.057	0.032	0.55
09	0.169	0.116	0.599	0.116
10	0.251	0.142	0.502	0.105
11	0.283	0.467	0.217	0.032
12	0.664	0.127	0.097	0.112
13	0.087	0.113	0.119	0.681
14	0.238	0.111	0.241	0.409
15	0.089	0.514	0.188	0.209
16	0.101	0.471	0.126	0.301

PWM

	A	C	G	T
01	0.762	-2.984	0.51	-1.951
02	0.009	0.9	-0.647	-4.981
03	1.373	-4.981	-3.361	-4.524
04	-4.981	-4.524	-4.212	1.378
05	-1.241	-4.212	-1.136	1.216
06	-4.212	1.338	-2.319	-2.597
07	-3.621	1.216	-4.981	-0.525
08	0.366	-1.454	-2.009	0.784
09	-0.387	-0.759	0.869	-0.759
10	0.005	-0.559	0.693	-0.857
11	0.124	0.623	-0.14	-2.009
12	0.972	-0.67	-0.935	-0.794
13	-1.042	-0.785	-0.734	0.997
14	-0.048	-0.802	-0.035	0.491
15	-1.019	0.716	-0.282	-0.177
16	-0.895	0.631	-0.677	0.185

Standard thresholds

P-value	Threshold
0.001	3.78601
0.0005	4.90441
0.0001	7.12936