TEAD4.H12CORE.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TEAD4.H12CORE.0.PS.A
Gene (human)	TEAD4 (GeneCards)
Gene synonyms (human)	RTEF1, TCF13L1, TEF3
Gene (mouse)	Tead4
Gene synonyms (mouse)	Tcf13r1, Tef3, Tefr1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	12
Consensus	nRMATTCCWdnv
GC content	46.93%
Information content (bits; total / per base)	11.145 / 0.929
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	27 (163)	0.87	0.95	0.786	0.907	0.863	0.94	3.269	4.214	244.959	651.357
Mouse	17 (104)	0.902	0.953	0.828	0.909	0.891	0.939	3.371	4.104	206.104	555.824

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	0.847	0.807	0.73	0.709	0.634	0.635
Non-Methyl HT-SELEX, 2 experiments	best	0.909	0.875	0.783	0.763	0.667	0.671

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	7.999	14.9	0.151	0.043

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	TEA domain factors {3.6} (TFClass)
TF family	TEF1-related {3.6.1} (TFClass)
TF subfamily	{3.6.1.0} (TFClass)
TFClass ID	TFClass: 3.6.1.0.2
HGNC	HGNC:11717
MGI	MGI:106907
EntrezGene (human)	GeneID:7004 (SSTAR profile)
EntrezGene (mouse)	GeneID:21679 (SSTAR profile)
UniProt ID (human)	TEAD4_HUMAN
UniProt ID (mouse)	TEAD4_MOUSE
UniProt AC (human)	Q15561 (TFClass)
UniProt AC (mouse)	Q62296 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	27 human, 17 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	TEAD4.H12CORE.0.PS.A.pcm
PWM	TEAD4.H12CORE.0.PS.A.pwm
PFM	TEAD4.H12CORE.0.PS.A.pfm
Alignment	TEAD4.H12CORE.0.PS.A.words.tsv
Threshold to P-value map	TEAD4.H12CORE.0.PS.A.thr
Motif in other formats
JASPAR format	TEAD4.H12CORE.0.PS.A_jaspar_format.txt
MEME format	TEAD4.H12CORE.0.PS.A_meme_format.meme
Transfac format	TEAD4.H12CORE.0.PS.A_transfac_format.txt
Homer format	TEAD4.H12CORE.0.PS.A_homer_format_0.001.txt TEAD4.H12CORE.0.PS.A_homer_format_0.0005.txt TEAD4.H12CORE.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	180.25	358.25	219.25	242.25
02	559.25	18.25	411.25	11.25
03	256.0	693.0	48.0	3.0
04	981.0	6.0	8.0	5.0
05	3.0	2.0	3.0	992.0
06	36.0	4.0	15.0	945.0
07	4.0	947.0	8.0	41.0
08	6.0	871.0	6.0	117.0
09	456.0	35.0	46.0	463.0
10	168.0	143.0	499.0	190.0
11	228.0	283.0	314.0	175.0
12	190.0	380.0	314.0	116.0

PFM

	A	C	G	T
01	0.18	0.358	0.219	0.242
02	0.559	0.018	0.411	0.011
03	0.256	0.693	0.048	0.003
04	0.981	0.006	0.008	0.005
05	0.003	0.002	0.003	0.992
06	0.036	0.004	0.015	0.945
07	0.004	0.947	0.008	0.041
08	0.006	0.871	0.006	0.117
09	0.456	0.035	0.046	0.463
10	0.168	0.143	0.499	0.19
11	0.228	0.283	0.314	0.175
12	0.19	0.38	0.314	0.116

PWM

	A	C	G	T
01	-0.324	0.358	-0.13	-0.031
02	0.801	-2.534	0.495	-2.965
03	0.024	1.015	-1.622	-3.975
04	1.362	-3.484	-3.253	-3.622
05	-3.975	-4.213	-3.975	1.373
06	-1.898	-3.783	-2.711	1.325
07	-3.783	1.327	-3.253	-1.774
08	-3.484	1.243	-3.484	-0.752
09	0.598	-1.925	-1.663	0.613
10	-0.394	-0.553	0.688	-0.272
11	-0.091	0.123	0.227	-0.354
12	-0.272	0.416	0.227	-0.76

Standard thresholds

P-value	Threshold
0.001	4.30896
0.0005	5.32863
0.0001	7.55633