TEAD1.H12CORE.1.P.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TEAD1.H12CORE.1.P.C
Gene (human)	TEAD1 (GeneCards)
Gene synonyms (human)	TCF13, TEF1
Gene (mouse)	Tead1
Gene synonyms (mouse)	Tcf13, Tef-1, Tef1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	C

Motif length	13
Consensus	RMATTCCWddvWK
GC content	37.25%
Information content (bits; total / per base)	11.484 / 0.883
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	12 (82)	0.85	0.904	0.742	0.833	0.859	0.91	3.083	4.003	261.927	544.252
Mouse	5 (31)	0.831	0.903	0.717	0.827	0.806	0.884	2.612	3.434	319.959	594.328

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.854	0.827	0.793	0.771	0.743	0.726
Overall, 4 experiments	best	0.964	0.939	0.946	0.916	0.911	0.877
Methyl HT-SELEX, 1 experiments	median	0.964	0.939	0.946	0.916	0.911	0.877
Methyl HT-SELEX, 1 experiments	best	0.964	0.939	0.946	0.916	0.911	0.877
Non-Methyl HT-SELEX, 3 experiments	median	0.749	0.722	0.646	0.635	0.581	0.584
Non-Methyl HT-SELEX, 3 experiments	best	0.959	0.932	0.94	0.907	0.905	0.868

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	17.02	3.625	0.274	0.131

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.796	0.556	0.815	0.589

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	TEA domain factors {3.6} (TFClass)
TF family	TEF1-related {3.6.1} (TFClass)
TF subfamily	{3.6.1.0} (TFClass)
TFClass ID	TFClass: 3.6.1.0.1
HGNC	HGNC:11714
MGI	MGI:101876
EntrezGene (human)	GeneID:7003 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	TEAD1_HUMAN
UniProt ID (mouse)	TEAD1_MOUSE
UniProt AC (human)	P28347 (TFClass)
UniProt AC (mouse)	P30051 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	12 human, 5 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	TEAD1.H12CORE.1.P.C.pcm
PWM	TEAD1.H12CORE.1.P.C.pwm
PFM	TEAD1.H12CORE.1.P.C.pfm
Alignment	TEAD1.H12CORE.1.P.C.words.tsv
Threshold to P-value map	TEAD1.H12CORE.1.P.C.thr
Motif in other formats
JASPAR format	TEAD1.H12CORE.1.P.C_jaspar_format.txt
MEME format	TEAD1.H12CORE.1.P.C_meme_format.meme
Transfac format	TEAD1.H12CORE.1.P.C_transfac_format.txt
Homer format	TEAD1.H12CORE.1.P.C_homer_format_0.001.txt TEAD1.H12CORE.1.P.C_homer_format_0.0005.txt TEAD1.H12CORE.1.P.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	610.0	21.0	315.0	54.0
02	290.0	666.0	37.0	7.0
03	979.0	6.0	4.0	11.0
04	3.0	6.0	6.0	985.0
05	73.0	8.0	47.0	872.0
06	4.0	873.0	42.0	81.0
07	13.0	665.0	0.0	322.0
08	325.0	58.0	14.0	603.0
09	181.0	166.0	385.0	268.0
10	322.0	119.0	418.0	141.0
11	269.0	475.0	187.0	69.0
12	709.0	55.0	73.0	163.0
13	98.0	61.0	135.0	706.0

PFM

	A	C	G	T
01	0.61	0.021	0.315	0.054
02	0.29	0.666	0.037	0.007
03	0.979	0.006	0.004	0.011
04	0.003	0.006	0.006	0.985
05	0.073	0.008	0.047	0.872
06	0.004	0.873	0.042	0.081
07	0.013	0.665	0.0	0.322
08	0.325	0.058	0.014	0.603
09	0.181	0.166	0.385	0.268
10	0.322	0.119	0.418	0.141
11	0.269	0.475	0.187	0.069
12	0.709	0.055	0.073	0.163
13	0.098	0.061	0.135	0.706

PWM

	A	C	G	T
01	0.888	-2.405	0.23	-1.508
02	0.147	0.976	-1.872	-3.362
03	1.36	-3.484	-3.783	-2.985
04	-3.975	-3.484	-3.484	1.366
05	-1.215	-3.253	-1.642	1.244
06	-3.783	1.246	-1.75	-1.113
07	-2.839	0.974	-4.982	0.252
08	0.261	-1.439	-2.773	0.876
09	-0.32	-0.406	0.429	0.069
10	0.252	-0.735	0.511	-0.567
11	0.073	0.639	-0.288	-1.27
12	1.038	-1.49	-1.215	-0.424
13	-0.926	-1.39	-0.61	1.034

Standard thresholds

P-value	Threshold
0.001	4.34586
0.0005	5.32116
0.0001	7.28256