MotifTCF7.H12INVIVO.0.PSM.A
Gene (human)TCF7
(GeneCards)
Gene synonyms (human)TCF1
Gene (mouse)Tcf7
Gene synonyms (mouse)Tcf-1, Tcf1
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length15
ConsensusnnnvRSWTSAAAGvv
GC content45.55%
Information content (bits; total / per base)10.854 / 0.724
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words999

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 10 (59) 0.837 0.908 0.734 0.85 0.832 0.896 2.777 3.587 50.036 353.229
Mouse 5 (32) 0.808 0.844 0.71 0.752 0.809 0.839 2.76 2.916 77.983 212.509

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 2 experiments median 0.912 0.892 0.743 0.747 0.61 0.643
best 0.932 0.917 0.758 0.765 0.616 0.653
Methyl HT-SELEX, 1 experiments median 0.932 0.917 0.758 0.765 0.616 0.653
best 0.932 0.917 0.758 0.765 0.616 0.653
Non-Methyl HT-SELEX, 1 experiments median 0.892 0.868 0.729 0.729 0.604 0.633
best 0.892 0.868 0.729 0.729 0.604 0.633

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.45 0.076 0.34 0.114
TF superclassOther all-alpha-helical DNA-binding domains {4} (TFClass)
TF classHigh-mobility group (HMG) domain factors {4.1} (TFClass)
TF familyTCF7-related {4.1.3} (TFClass)
TF subfamily {4.1.3.0} (TFClass)
TFClass IDTFClass: 4.1.3.0.1
HGNCHGNC:11639
MGIMGI:98507
EntrezGene (human)GeneID:6932
(SSTAR profile)
EntrezGene (mouse)GeneID:21414
(SSTAR profile)
UniProt ID (human)TCF7_HUMAN
UniProt ID (mouse)TCF7_MOUSE
UniProt AC (human)P36402
(TFClass)
UniProt AC (mouse)Q00417
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 10 human, 5 mouse
HT-SELEX 1
Methyl-HT-SELEX 1
PCM
ACGT
01320.0225.0290.0164.0
02309.0254.0267.0169.0
03238.0362.0258.0141.0
04285.0388.0254.072.0
05732.035.0141.091.0
0615.0584.0372.028.0
07651.035.013.0300.0
08107.021.053.0818.0
0958.0773.0156.012.0
10960.08.09.022.0
11869.048.080.02.0
12940.05.043.011.0
13102.051.0830.016.0
14280.0208.0429.082.0
15277.0290.0344.088.0
PFM
ACGT
010.320.2250.290.164
020.3090.2540.2670.169
030.2380.3620.2580.141
040.2850.3880.2540.072
050.7330.0350.1410.091
060.0150.5850.3720.028
070.6520.0350.0130.3
080.1070.0210.0530.819
090.0580.7740.1560.012
100.9610.0080.0090.022
110.870.0480.080.002
120.9410.0050.0430.011
130.1020.0510.8310.016
140.280.2080.4290.082
150.2770.290.3440.088
PWM
ACGT
010.246-0.1040.148-0.417
020.2120.0170.066-0.387
03-0.0480.3690.032-0.566
040.1310.4380.017-1.227
051.071-1.924-0.566-0.998
06-2.710.8460.396-2.135
070.954-1.924-2.8380.182
08-0.839-2.404-1.5251.182
09-1.4381.125-0.466-2.908
101.341-3.252-3.155-2.361
111.242-1.621-1.124-4.212
121.32-3.621-1.727-2.984
13-0.886-1.5621.196-2.652
140.114-0.1820.538-1.1
150.1030.1480.318-1.031
Standard thresholds
P-value Threshold
0.001 4.52101
0.0005 5.41461
0.0001 7.24951