SRBP1.H12RSNP.0.P.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	SRBP1.H12RSNP.0.P.D
Gene (human)	SREBF1 (GeneCards)
Gene synonyms (human)	BHLHD1, SREBP1
Gene (mouse)	Srebf1
Gene synonyms (mouse)	Srebp1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	D

Motif length	12
Consensus	RTCASGTGAYbb
GC content	53.47%
Information content (bits; total / per base)	12.222 / 1.019
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (20)	0.866	0.935	0.807	0.897	0.861	0.936	4.185	5.495	107.016	489.959
Mouse	2 (14)	0.785	0.882	0.702	0.778	0.702	0.822	2.243	2.615	155.444	276.328

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.774	0.75	0.66	0.652	0.595	0.597
Overall, 4 experiments	best	0.919	0.892	0.829	0.799	0.733	0.715
Methyl HT-SELEX, 1 experiments	median	0.919	0.892	0.829	0.799	0.733	0.715
Methyl HT-SELEX, 1 experiments	best	0.919	0.892	0.829	0.799	0.733	0.715
Non-Methyl HT-SELEX, 3 experiments	median	0.77	0.728	0.626	0.645	0.561	0.583
Non-Methyl HT-SELEX, 3 experiments	best	0.777	0.773	0.694	0.659	0.628	0.611

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	SREBF {1.2.6.3} (TFClass)
TFClass ID	TFClass: 1.2.6.3.1
HGNC	HGNC:11289
MGI	MGI:107606
EntrezGene (human)	GeneID:6720 (SSTAR profile)
EntrezGene (mouse)	GeneID:20787 (SSTAR profile)
UniProt ID (human)	SRBP1_HUMAN
UniProt ID (mouse)	SRBP1_MOUSE
UniProt AC (human)	P36956 (TFClass)
UniProt AC (mouse)	Q9WTN3 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 2 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	SRBP1.H12RSNP.0.P.D.pcm
PWM	SRBP1.H12RSNP.0.P.D.pwm
PFM	SRBP1.H12RSNP.0.P.D.pfm
Alignment	SRBP1.H12RSNP.0.P.D.words.tsv
Threshold to P-value map	SRBP1.H12RSNP.0.P.D.thr
Motif in other formats
JASPAR format	SRBP1.H12RSNP.0.P.D_jaspar_format.txt
MEME format	SRBP1.H12RSNP.0.P.D_meme_format.meme
Transfac format	SRBP1.H12RSNP.0.P.D_transfac_format.txt
Homer format	SRBP1.H12RSNP.0.P.D_homer_format_0.001.txt SRBP1.H12RSNP.0.P.D_homer_format_0.0005.txt SRBP1.H12RSNP.0.P.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	421.0	151.0	425.0	3.0
02	38.0	30.0	29.0	903.0
03	15.0	718.0	263.0	4.0
04	729.0	0.0	244.0	27.0
05	17.0	339.0	599.0	45.0
06	19.0	44.0	932.0	5.0
07	31.0	16.0	6.0	947.0
08	1.0	16.0	982.0	1.0
09	937.0	17.0	22.0	24.0
10	9.0	324.0	109.0	558.0
11	111.0	449.0	190.0	250.0
12	128.0	369.0	143.0	360.0

PFM

	A	C	G	T
01	0.421	0.151	0.425	0.003
02	0.038	0.03	0.029	0.903
03	0.015	0.718	0.263	0.004
04	0.729	0.0	0.244	0.027
05	0.017	0.339	0.599	0.045
06	0.019	0.044	0.932	0.005
07	0.031	0.016	0.006	0.947
08	0.001	0.016	0.982	0.001
09	0.937	0.017	0.022	0.024
10	0.009	0.324	0.109	0.558
11	0.111	0.449	0.19	0.25
12	0.128	0.369	0.143	0.36

PWM

	A	C	G	T
01	0.518	-0.5	0.528	-3.975
02	-1.846	-2.071	-2.103	1.279
03	-2.711	1.051	0.05	-3.783
04	1.066	-4.982	-0.024	-2.171
05	-2.598	0.303	0.87	-1.684
06	-2.497	-1.706	1.311	-3.622
07	-2.04	-2.653	-3.484	1.327
08	-4.525	-2.653	1.363	-4.525
09	1.316	-2.598	-2.362	-2.281
10	-3.156	0.258	-0.821	0.799
11	-0.803	0.583	-0.272	0.0
12	-0.663	0.387	-0.553	0.363

Standard thresholds

P-value	Threshold
0.001	3.984825
0.0005	5.105915
0.0001	7.10493