SRBP1.H12INVIVO.1.S.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	SRBP1.H12INVIVO.1.S.C
Gene (human)	SREBF1 (GeneCards)
Gene synonyms (human)	BHLHD1, SREBP1
Gene (mouse)	Srebf1
Gene synonyms (mouse)	Srebp1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	C

Motif length	12
Consensus	bdWSRCGTGAbv
GC content	58.12%
Information content (bits; total / per base)	11.18 / 0.932
Data sources	HT-SELEX
Aligned words	1327

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (20)	0.838	0.895	0.76	0.841	0.83	0.896	3.169	4.689	103.858	433.796
Mouse	2 (14)	0.727	0.752	0.587	0.627	0.634	0.655	1.55	1.886	96.879	141.959

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.783	0.757	0.686	0.667	0.625	0.614
Overall, 4 experiments	best	0.835	0.772	0.761	0.712	0.687	0.656
Methyl HT-SELEX, 1 experiments	median	0.835	0.772	0.761	0.712	0.687	0.656
Methyl HT-SELEX, 1 experiments	best	0.835	0.772	0.761	0.712	0.687	0.656
Non-Methyl HT-SELEX, 3 experiments	median	0.758	0.757	0.641	0.646	0.581	0.59
Non-Methyl HT-SELEX, 3 experiments	best	0.807	0.757	0.73	0.688	0.668	0.639

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	SREBF {1.2.6.3} (TFClass)
TFClass ID	TFClass: 1.2.6.3.1
HGNC	HGNC:11289
MGI	MGI:107606
EntrezGene (human)	GeneID:6720 (SSTAR profile)
EntrezGene (mouse)	GeneID:20787 (SSTAR profile)
UniProt ID (human)	SRBP1_HUMAN
UniProt ID (mouse)	SRBP1_MOUSE
UniProt AC (human)	P36956 (TFClass)
UniProt AC (mouse)	Q9WTN3 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 2 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	SRBP1.H12INVIVO.1.S.C.pcm
PWM	SRBP1.H12INVIVO.1.S.C.pwm
PFM	SRBP1.H12INVIVO.1.S.C.pfm
Alignment	SRBP1.H12INVIVO.1.S.C.words.tsv
Threshold to P-value map	SRBP1.H12INVIVO.1.S.C.thr
Motif in other formats
JASPAR format	SRBP1.H12INVIVO.1.S.C_jaspar_format.txt
MEME format	SRBP1.H12INVIVO.1.S.C_meme_format.meme
Transfac format	SRBP1.H12INVIVO.1.S.C_transfac_format.txt
Homer format	SRBP1.H12INVIVO.1.S.C_homer_format_0.001.txt SRBP1.H12INVIVO.1.S.C_homer_format_0.0005.txt SRBP1.H12INVIVO.1.S.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	197.0	299.0	515.0	316.0
02	456.75	174.75	477.75	217.75
03	299.0	23.0	255.0	750.0
04	200.0	832.0	205.0	90.0
05	566.0	0.0	753.0	8.0
06	0.0	1233.0	94.0	0.0
07	0.0	0.0	1327.0	0.0
08	0.0	0.0	0.0	1327.0
09	18.0	0.0	1277.0	32.0
10	1101.0	11.0	199.0	16.0
11	81.0	307.0	344.0	595.0
12	246.5	310.5	617.5	152.5

PFM

	A	C	G	T
01	0.148	0.225	0.388	0.238
02	0.344	0.132	0.36	0.164
03	0.225	0.017	0.192	0.565
04	0.151	0.627	0.154	0.068
05	0.427	0.0	0.567	0.006
06	0.0	0.929	0.071	0.0
07	0.0	0.0	1.0	0.0
08	0.0	0.0	0.0	1.0
09	0.014	0.0	0.962	0.024
10	0.83	0.008	0.15	0.012
11	0.061	0.231	0.259	0.448
12	0.186	0.234	0.465	0.115

PWM

	A	C	G	T
01	-0.517	-0.103	0.438	-0.048
02	0.318	-0.636	0.363	-0.418
03	-0.103	-2.599	-0.261	0.813
04	-0.503	0.916	-0.478	-1.29
05	0.532	-5.223	0.817	-3.528
06	-5.223	1.309	-1.248	-5.223
07	-5.223	-5.223	1.382	-5.223
08	-5.223	-5.223	-5.223	1.382
09	-2.824	-5.223	1.344	-2.289
10	1.196	-3.261	-0.507	-2.931
11	-1.393	-0.077	0.036	0.582
12	-0.295	-0.066	0.619	-0.771

Standard thresholds

P-value	Threshold
0.001	4.34316
0.0005	5.54052
0.0001	7.599915