SRBP1.H12INVIVO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	SRBP1.H12INVIVO.0.P.B
Gene (human)	SREBF1 (GeneCards)
Gene synonyms (human)	BHLHD1, SREBP1
Gene (mouse)	Srebf1
Gene synonyms (mouse)	Srebp1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	vvRTSRGGTGAY
GC content	54.64%
Information content (bits; total / per base)	13.16 / 1.097
Data sources	ChIP-Seq
Aligned words	124

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (20)	0.868	0.941	0.814	0.909	0.866	0.936	3.767	4.943	101.459	495.678
Mouse	2 (14)	0.787	0.873	0.699	0.775	0.716	0.828	2.283	2.68	158.379	271.237

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.744	0.72	0.639	0.631	0.583	0.584
Overall, 4 experiments	best	0.894	0.862	0.801	0.768	0.722	0.697
Methyl HT-SELEX, 1 experiments	median	0.894	0.862	0.801	0.768	0.722	0.697
Methyl HT-SELEX, 1 experiments	best	0.894	0.862	0.801	0.768	0.722	0.697
Non-Methyl HT-SELEX, 3 experiments	median	0.744	0.694	0.611	0.629	0.553	0.574
Non-Methyl HT-SELEX, 3 experiments	best	0.744	0.746	0.667	0.634	0.613	0.594

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	SREBF {1.2.6.3} (TFClass)
TFClass ID	TFClass: 1.2.6.3.1
HGNC	HGNC:11289
MGI	MGI:107606
EntrezGene (human)	GeneID:6720 (SSTAR profile)
EntrezGene (mouse)	GeneID:20787 (SSTAR profile)
UniProt ID (human)	SRBP1_HUMAN
UniProt ID (mouse)	SRBP1_MOUSE
UniProt AC (human)	P36956 (TFClass)
UniProt AC (mouse)	Q9WTN3 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 2 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	SRBP1.H12INVIVO.0.P.B.pcm
PWM	SRBP1.H12INVIVO.0.P.B.pwm
PFM	SRBP1.H12INVIVO.0.P.B.pfm
Alignment	SRBP1.H12INVIVO.0.P.B.words.tsv
Threshold to P-value map	SRBP1.H12INVIVO.0.P.B.thr
Motif in other formats
JASPAR format	SRBP1.H12INVIVO.0.P.B_jaspar_format.txt
MEME format	SRBP1.H12INVIVO.0.P.B_meme_format.meme
Transfac format	SRBP1.H12INVIVO.0.P.B_transfac_format.txt
Homer format	SRBP1.H12INVIVO.0.P.B_homer_format_0.001.txt SRBP1.H12INVIVO.0.P.B_homer_format_0.0005.txt SRBP1.H12INVIVO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	30.0	40.0	48.0	6.0
02	51.0	22.0	45.0	6.0
03	54.0	18.0	51.0	1.0
04	3.0	1.0	4.0	116.0
05	1.0	70.0	53.0	0.0
06	73.0	0.0	43.0	8.0
07	0.0	33.0	89.0	2.0
08	1.0	7.0	116.0	0.0
09	5.0	1.0	0.0	118.0
10	0.0	0.0	124.0	0.0
11	120.0	1.0	0.0	3.0
12	0.0	35.0	12.0	77.0

PFM

	A	C	G	T
01	0.242	0.323	0.387	0.048
02	0.411	0.177	0.363	0.048
03	0.435	0.145	0.411	0.008
04	0.024	0.008	0.032	0.935
05	0.008	0.565	0.427	0.0
06	0.589	0.0	0.347	0.065
07	0.0	0.266	0.718	0.016
08	0.008	0.056	0.935	0.0
09	0.04	0.008	0.0	0.952
10	0.0	0.0	1.0	0.0
11	0.968	0.008	0.0	0.024
12	0.0	0.282	0.097	0.621

PWM

	A	C	G	T
01	-0.032	0.246	0.424	-1.497
02	0.483	-0.328	0.361	-1.497
03	0.539	-0.517	0.483	-2.681
04	-2.036	-2.681	-1.822	1.292
05	-2.681	0.793	0.521	-3.286
06	0.835	-3.286	0.317	-1.252
07	-3.286	0.06	1.03	-2.307
08	-2.681	-1.367	1.292	-3.286
09	-1.647	-2.681	-3.286	1.309
10	-3.286	-3.286	1.358	-3.286
11	1.325	-2.681	-3.286	-2.036
12	-3.286	0.117	-0.892	0.887

Standard thresholds

P-value	Threshold
0.001	4.082815
0.0005	5.157285
0.0001	7.13313