SRBP1.H12INVITRO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	SRBP1.H12INVITRO.0.P.B
Gene (human)	SREBF1 (GeneCards)
Gene synonyms (human)	BHLHD1, SREBP1
Gene (mouse)	Srebf1
Gene synonyms (mouse)	Srebp1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	11
Consensus	RTCASGTGAYb
GC content	57.13%
Information content (bits; total / per base)	11.646 / 1.059
Data sources	ChIP-Seq
Aligned words	934

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (20)	0.867	0.934	0.823	0.891	0.854	0.929	4.208	5.439	101.849	478.745
Mouse	2 (14)	0.78	0.862	0.695	0.755	0.697	0.785	2.211	2.35	139.831	239.032

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.781	0.758	0.668	0.659	0.599	0.601
Overall, 4 experiments	best	0.903	0.872	0.809	0.778	0.721	0.701
Methyl HT-SELEX, 1 experiments	median	0.903	0.872	0.809	0.778	0.721	0.701
Methyl HT-SELEX, 1 experiments	best	0.903	0.872	0.809	0.778	0.721	0.701
Non-Methyl HT-SELEX, 3 experiments	median	0.779	0.736	0.638	0.653	0.569	0.589
Non-Methyl HT-SELEX, 3 experiments	best	0.782	0.78	0.699	0.665	0.63	0.614

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	SREBF {1.2.6.3} (TFClass)
TFClass ID	TFClass: 1.2.6.3.1
HGNC	HGNC:11289
MGI	MGI:107606
EntrezGene (human)	GeneID:6720 (SSTAR profile)
EntrezGene (mouse)	GeneID:20787 (SSTAR profile)
UniProt ID (human)	SRBP1_HUMAN
UniProt ID (mouse)	SRBP1_MOUSE
UniProt AC (human)	P36956 (TFClass)
UniProt AC (mouse)	Q9WTN3 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 2 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	SRBP1.H12INVITRO.0.P.B.pcm
PWM	SRBP1.H12INVITRO.0.P.B.pwm
PFM	SRBP1.H12INVITRO.0.P.B.pfm
Alignment	SRBP1.H12INVITRO.0.P.B.words.tsv
Threshold to P-value map	SRBP1.H12INVITRO.0.P.B.thr
Motif in other formats
JASPAR format	SRBP1.H12INVITRO.0.P.B_jaspar_format.txt
MEME format	SRBP1.H12INVITRO.0.P.B_meme_format.meme
Transfac format	SRBP1.H12INVITRO.0.P.B_transfac_format.txt
Homer format	SRBP1.H12INVITRO.0.P.B_homer_format_0.001.txt SRBP1.H12INVITRO.0.P.B_homer_format_0.0005.txt SRBP1.H12INVITRO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	276.0	63.0	583.0	12.0
02	31.0	28.0	35.0	840.0
03	23.0	718.0	183.0	10.0
04	727.0	8.0	183.0	16.0
05	12.0	499.0	388.0	35.0
06	12.0	17.0	897.0	8.0
07	49.0	7.0	39.0	839.0
08	6.0	12.0	909.0	7.0
09	784.0	10.0	81.0	59.0
10	7.0	316.0	206.0	405.0
11	78.0	442.0	246.0	168.0

PFM

	A	C	G	T
01	0.296	0.067	0.624	0.013
02	0.033	0.03	0.037	0.899
03	0.025	0.769	0.196	0.011
04	0.778	0.009	0.196	0.017
05	0.013	0.534	0.415	0.037
06	0.013	0.018	0.96	0.009
07	0.052	0.007	0.042	0.898
08	0.006	0.013	0.973	0.007
09	0.839	0.011	0.087	0.063
10	0.007	0.338	0.221	0.434
11	0.084	0.473	0.263	0.18

PWM

	A	C	G	T
01	0.166	-1.291	0.911	-2.842
02	-1.973	-2.069	-1.857	1.275
03	-2.253	1.118	-0.242	-3.0
04	1.131	-3.187	-0.242	-2.586
05	-2.842	0.756	0.505	-1.857
06	-2.842	-2.531	1.34	-3.187
07	-1.534	-3.296	-1.754	1.274
08	-3.418	-2.842	1.354	-3.296
09	1.206	-3.0	-1.045	-1.354
10	-3.296	0.301	-0.124	0.548
11	-1.082	0.635	0.052	-0.326

Standard thresholds

P-value	Threshold
0.001	4.239285
0.0005	5.234685
0.0001	7.19482