SPIB.H12RSNP.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	SPIB.H12RSNP.0.P.B
Gene (human)	SPIB (GeneCards)
Gene synonyms (human)
Gene (mouse)	Spib
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	17
Consensus	vRARWGRGGAAGTGRvd
GC content	45.05%
Information content (bits; total / per base)	18.484 / 1.087
Data sources	ChIP-Seq
Aligned words	877

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (26)	0.982	0.988	0.966	0.976	0.985	0.99	6.709	7.148	634.421	825.959
Mouse	1 (5)	0.925	0.941	0.907	0.919	0.943	0.955	5.91	5.985	526.26	611.036

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 7 experiments	median	0.973	0.958	0.9	0.892	0.793	0.778
Overall, 7 experiments	best	0.999	0.998	0.993	0.991	0.956	0.95
Methyl HT-SELEX, 3 experiments	median	0.973	0.958	0.936	0.914	0.845	0.828
Methyl HT-SELEX, 3 experiments	best	0.999	0.998	0.993	0.991	0.956	0.95
Non-Methyl HT-SELEX, 4 experiments	median	0.971	0.957	0.899	0.882	0.753	0.762
Non-Methyl HT-SELEX, 4 experiments	best	0.995	0.992	0.985	0.979	0.947	0.936

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.894	0.479	0.872	0.577
batch 2	0.748	0.399	0.683	0.528

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	SPI-like {3.5.2.5} (TFClass)
TFClass ID	TFClass: 3.5.2.5.2
HGNC	HGNC:11242
MGI	MGI:892986
EntrezGene (human)	GeneID:6689 (SSTAR profile)
EntrezGene (mouse)	GeneID:272382 (SSTAR profile)
UniProt ID (human)	SPIB_HUMAN
UniProt ID (mouse)	SPIB_MOUSE
UniProt AC (human)	Q01892 (TFClass)
UniProt AC (mouse)	O35906 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 1 mouse
HT-SELEX	4
Methyl-HT-SELEX	3

PCM	SPIB.H12RSNP.0.P.B.pcm
PWM	SPIB.H12RSNP.0.P.B.pwm
PFM	SPIB.H12RSNP.0.P.B.pfm
Alignment	SPIB.H12RSNP.0.P.B.words.tsv
Threshold to P-value map	SPIB.H12RSNP.0.P.B.thr
Motif in other formats
JASPAR format	SPIB.H12RSNP.0.P.B_jaspar_format.txt
MEME format	SPIB.H12RSNP.0.P.B_meme_format.meme
Transfac format	SPIB.H12RSNP.0.P.B_transfac_format.txt
Homer format	SPIB.H12RSNP.0.P.B_homer_format_0.001.txt SPIB.H12RSNP.0.P.B_homer_format_0.0005.txt SPIB.H12RSNP.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	350.0	167.0	220.0	140.0
02	427.0	93.0	317.0	40.0
03	708.0	23.0	95.0	51.0
04	674.0	26.0	147.0	30.0
05	646.0	7.0	64.0	160.0
06	99.0	38.0	730.0	10.0
07	588.0	54.0	230.0	5.0
08	48.0	0.0	829.0	0.0
09	1.0	0.0	876.0	0.0
10	877.0	0.0	0.0	0.0
11	870.0	1.0	2.0	4.0
12	26.0	151.0	699.0	1.0
13	11.0	6.0	7.0	853.0
14	6.0	28.0	843.0	0.0
15	491.0	104.0	249.0	33.0
16	328.0	137.0	295.0	117.0
17	461.0	118.0	161.0	137.0

PFM

	A	C	G	T
01	0.399	0.19	0.251	0.16
02	0.487	0.106	0.361	0.046
03	0.807	0.026	0.108	0.058
04	0.769	0.03	0.168	0.034
05	0.737	0.008	0.073	0.182
06	0.113	0.043	0.832	0.011
07	0.67	0.062	0.262	0.006
08	0.055	0.0	0.945	0.0
09	0.001	0.0	0.999	0.0
10	1.0	0.0	0.0	0.0
11	0.992	0.001	0.002	0.005
12	0.03	0.172	0.797	0.001
13	0.013	0.007	0.008	0.973
14	0.007	0.032	0.961	0.0
15	0.56	0.119	0.284	0.038
16	0.374	0.156	0.336	0.133
17	0.526	0.135	0.184	0.156

PWM

	A	C	G	T
01	0.465	-0.27	0.003	-0.444
02	0.663	-0.847	0.366	-1.668
03	1.167	-2.191	-0.826	-1.433
04	1.118	-2.077	-0.396	-1.942
05	1.076	-3.235	-1.213	-0.312
06	-0.786	-1.717	1.197	-2.939
07	0.982	-1.378	0.048	-3.497
08	-1.492	-4.871	1.324	-4.871
09	-4.407	-4.871	1.379	-4.871
10	1.381	-4.871	-4.871	-4.871
11	1.373	-4.407	-4.091	-3.658
12	-2.077	-0.369	1.154	-4.407
13	-2.857	-3.357	-3.235	1.353
14	-3.357	-2.007	1.341	-4.871
15	0.802	-0.737	0.126	-1.851
16	0.4	-0.466	0.295	-0.621
17	0.739	-0.613	-0.306	-0.466

Standard thresholds

P-value	Threshold
0.001	0.66691
0.0005	2.13966
0.0001	5.22226