SPI1.H12RSNP.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	SPI1.H12RSNP.1.S.B
Gene (human)	SPI1 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Spi1
Gene synonyms (mouse)	Sfpi-1, Sfpi1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	12
Consensus	dddvGGAAGYdn
GC content	54.03%
Information content (bits; total / per base)	11.251 / 0.938
Data sources	HT-SELEX
Aligned words	1641

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	94 (173)	0.929	0.968	0.86	0.924	0.915	0.96	3.73	4.307	408.658	762.268
Mouse	158 (286)	0.927	0.954	0.866	0.934	0.919	0.954	3.787	4.329	418.511	699.097

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	0.61	0.597	0.551	0.553	0.524	0.53
Non-Methyl HT-SELEX, 2 experiments	best	0.643	0.629	0.57	0.571	0.535	0.542

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	3.525	128.69	0.316	0.222

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	SPI-like {3.5.2.5} (TFClass)
TFClass ID	TFClass: 3.5.2.5.1
HGNC	HGNC:11241
MGI	MGI:98282
EntrezGene (human)	GeneID:6688 (SSTAR profile)
EntrezGene (mouse)	GeneID:20375 (SSTAR profile)
UniProt ID (human)	SPI1_HUMAN
UniProt ID (mouse)	SPI1_MOUSE
UniProt AC (human)	P17947 (TFClass)
UniProt AC (mouse)	P17433 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	94 human, 158 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	SPI1.H12RSNP.1.S.B.pcm
PWM	SPI1.H12RSNP.1.S.B.pwm
PFM	SPI1.H12RSNP.1.S.B.pfm
Alignment	SPI1.H12RSNP.1.S.B.words.tsv
Threshold to P-value map	SPI1.H12RSNP.1.S.B.thr
Motif in other formats
JASPAR format	SPI1.H12RSNP.1.S.B_jaspar_format.txt
MEME format	SPI1.H12RSNP.1.S.B_meme_format.meme
Transfac format	SPI1.H12RSNP.1.S.B_transfac_format.txt
Homer format	SPI1.H12RSNP.1.S.B_homer_format_0.001.txt SPI1.H12RSNP.1.S.B_homer_format_0.0005.txt SPI1.H12RSNP.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	610.0	178.0	508.0	345.0
02	533.5	153.5	471.5	482.5
03	281.0	186.0	934.0	240.0
04	320.0	436.0	828.0	57.0
05	3.0	7.0	1631.0	0.0
06	0.0	0.0	1641.0	0.0
07	1640.0	0.0	1.0	0.0
08	1638.0	0.0	0.0	3.0
09	15.0	64.0	1562.0	0.0
10	156.0	257.0	167.0	1061.0
11	559.0	158.0	629.0	295.0
12	417.0	329.0	498.0	397.0

PFM

	A	C	G	T
01	0.372	0.108	0.31	0.21
02	0.325	0.094	0.287	0.294
03	0.171	0.113	0.569	0.146
04	0.195	0.266	0.505	0.035
05	0.002	0.004	0.994	0.0
06	0.0	0.0	1.0	0.0
07	0.999	0.0	0.001	0.0
08	0.998	0.0	0.0	0.002
09	0.009	0.039	0.952	0.0
10	0.095	0.157	0.102	0.647
11	0.341	0.096	0.383	0.18
12	0.254	0.2	0.303	0.242

PWM

	A	C	G	T
01	0.395	-0.829	0.213	-0.172
02	0.262	-0.976	0.139	0.162
03	-0.376	-0.786	0.82	-0.533
04	-0.247	0.061	0.7	-1.946
05	-4.442	-3.841	1.377	-5.406
06	-5.406	-5.406	1.383	-5.406
07	1.382	-5.406	-4.974	-5.406
08	1.381	-5.406	-5.406	-4.442
09	-3.197	-1.834	1.334	-5.406
10	-0.96	-0.465	-0.892	0.947
11	0.308	-0.947	0.426	-0.328
12	0.016	-0.22	0.193	-0.033

Standard thresholds

P-value	Threshold
0.001	4.09136
0.0005	5.673925
0.0001	7.70146