MotifSPDEF.H12INVIVO.1.SM.B
Gene (human)SPDEF
(GeneCards)
Gene synonyms (human)PDEF, PSE
Gene (mouse)Spdef
Gene synonyms (mouse)Pdef, Pse
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length20
ConsensusnWhCCGGATGTdnnnhhbbn
GC content54.97%
Information content (bits; total / per base)14.681 / 0.734
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words840

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 2 (12) 0.804 0.876 0.712 0.792 0.765 0.844 2.468 2.971 55.308 111.284

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 8 experiments median 0.726 0.728 0.605 0.621 0.556 0.57
best 0.999 0.998 0.995 0.993 0.944 0.943
Methyl HT-SELEX, 2 experiments median 0.85 0.852 0.777 0.784 0.687 0.703
best 0.993 0.99 0.97 0.961 0.837 0.846
Non-Methyl HT-SELEX, 6 experiments median 0.701 0.694 0.604 0.608 0.556 0.565
best 0.999 0.998 0.995 0.993 0.944 0.943

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.748 0.608 0.693 0.465
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classTryptophan cluster factors {3.5} (TFClass)
TF familyEts-related {3.5.2} (TFClass)
TF subfamilySPDEF-like {3.5.2.7} (TFClass)
TFClass IDTFClass: 3.5.2.7.1
HGNCHGNC:17257
MGIMGI:1353422
EntrezGene (human)GeneID:25803
(SSTAR profile)
EntrezGene (mouse)GeneID:30051
(SSTAR profile)
UniProt ID (human)SPDEF_HUMAN
UniProt ID (mouse)SPDEF_MOUSE
UniProt AC (human)O95238
(TFClass)
UniProt AC (mouse)Q9WTP3
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 2 human, 0 mouse
HT-SELEX 6
Methyl-HT-SELEX 2
PCM
ACGT
01253.5168.5250.5167.5
02504.7545.7587.75201.75
03342.0267.0106.0125.0
0434.0748.056.02.0
05222.0616.02.00.0
060.00.0840.00.0
070.01.0839.00.0
08840.00.00.00.0
0917.04.00.0819.0
10126.017.0696.01.0
114.0209.07.0620.0
12286.087.0256.0211.0
13241.0261.0228.0110.0
14290.0230.0182.0138.0
15301.0154.0140.0245.0
16154.0304.0109.0273.0
17135.0463.089.0153.0
1877.0354.0274.0135.0
1980.5194.5465.599.5
20202.75161.75321.75153.75
PFM
ACGT
010.3020.2010.2980.199
020.6010.0540.1040.24
030.4070.3180.1260.149
040.040.890.0670.002
050.2640.7330.0020.0
060.00.01.00.0
070.00.0010.9990.0
081.00.00.00.0
090.020.0050.00.975
100.150.020.8290.001
110.0050.2490.0080.738
120.340.1040.3050.251
130.2870.3110.2710.131
140.3450.2740.2170.164
150.3580.1830.1670.292
160.1830.3620.130.325
170.1610.5510.1060.182
180.0920.4210.3260.161
190.0960.2320.5540.118
200.2410.1930.3830.183
PWM
ACGT
010.187-0.2180.175-0.224
020.872-1.496-0.862-0.04
030.4850.238-0.676-0.513
04-1.781.265-1.3-4.051
050.0551.071-4.051-4.834
06-4.834-4.8341.38-4.834
07-4.834-4.3681.379-4.834
081.38-4.834-4.834-4.834
09-2.427-3.618-4.8341.355
10-0.506-2.4271.193-4.368
11-3.618-0.005-3.1941.077
120.307-0.870.1970.005
130.1370.2160.082-0.639
140.3210.09-0.142-0.416
150.358-0.307-0.4010.153
16-0.3070.367-0.6480.261
17-0.4370.786-0.848-0.314
18-0.990.5190.264-0.437
19-0.946-0.0760.792-0.738
20-0.035-0.2590.424-0.309
Standard thresholds
P-value Threshold
0.001 2.57616
0.0005 3.91411
0.0001 6.71091