SP1.H12INVIVO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	SP1.H12INVIVO.0.P.B
Gene (human)	SP1 (GeneCards)
Gene synonyms (human)	TSFP1
Gene (mouse)	Sp1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	14
Consensus	nRKGGGCGGGGCYd
GC content	77.43%
Information content (bits; total / per base)	15.859 / 1.133
Data sources	ChIP-Seq
Aligned words	971

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	14 (91)	0.876	0.969	0.762	0.925	0.928	0.986	4.176	5.558	66.367	209.469
Mouse	10 (52)	0.898	0.958	0.815	0.905	0.899	0.963	4.034	4.554	68.678	176.745

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.995	0.992	0.948	0.934	0.746	0.781
Overall, 3 experiments	best	0.996	0.993	0.973	0.969	0.768	0.807
Methyl HT-SELEX, 1 experiments	median	0.995	0.992	0.902	0.906	0.681	0.738
Methyl HT-SELEX, 1 experiments	best	0.995	0.992	0.902	0.906	0.681	0.738
Non-Methyl HT-SELEX, 2 experiments	median	0.99	0.983	0.96	0.951	0.757	0.794
Non-Methyl HT-SELEX, 2 experiments	best	0.996	0.993	0.973	0.969	0.768	0.807

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	1.205	0.43	0.024	0.017

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Sp1-like {2.3.1.1} (TFClass)
TFClass ID	TFClass: 2.3.1.1.1
HGNC	HGNC:11205
MGI	MGI:98372
EntrezGene (human)	GeneID:6667 (SSTAR profile)
EntrezGene (mouse)	GeneID:20683 (SSTAR profile)
UniProt ID (human)	SP1_HUMAN
UniProt ID (mouse)	SP1_MOUSE
UniProt AC (human)	P08047 (TFClass)
UniProt AC (mouse)	O89090 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	14 human, 10 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	SP1.H12INVIVO.0.P.B.pcm
PWM	SP1.H12INVIVO.0.P.B.pwm
PFM	SP1.H12INVIVO.0.P.B.pfm
Alignment	SP1.H12INVIVO.0.P.B.words.tsv
Threshold to P-value map	SP1.H12INVIVO.0.P.B.thr
Motif in other formats
JASPAR format	SP1.H12INVIVO.0.P.B_jaspar_format.txt
MEME format	SP1.H12INVIVO.0.P.B_meme_format.meme
Transfac format	SP1.H12INVIVO.0.P.B_transfac_format.txt
Homer format	SP1.H12INVIVO.0.P.B_homer_format_0.001.txt SP1.H12INVIVO.0.P.B_homer_format_0.0005.txt SP1.H12INVIVO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	369.0	154.0	218.0	230.0
02	263.0	48.0	626.0	34.0
03	116.0	4.0	610.0	241.0
04	124.0	0.0	844.0	3.0
05	0.0	1.0	967.0	3.0
06	2.0	1.0	965.0	3.0
07	24.0	891.0	0.0	56.0
08	4.0	4.0	959.0	4.0
09	6.0	4.0	753.0	208.0
10	149.0	4.0	798.0	20.0
11	62.0	13.0	866.0	30.0
12	39.0	849.0	10.0	73.0
13	58.0	538.0	93.0	282.0
14	222.0	70.0	236.0	443.0

PFM

	A	C	G	T
01	0.38	0.159	0.225	0.237
02	0.271	0.049	0.645	0.035
03	0.119	0.004	0.628	0.248
04	0.128	0.0	0.869	0.003
05	0.0	0.001	0.996	0.003
06	0.002	0.001	0.994	0.003
07	0.025	0.918	0.0	0.058
08	0.004	0.004	0.988	0.004
09	0.006	0.004	0.775	0.214
10	0.153	0.004	0.822	0.021
11	0.064	0.013	0.892	0.031
12	0.04	0.874	0.01	0.075
13	0.06	0.554	0.096	0.29
14	0.229	0.072	0.243	0.456

PWM

	A	C	G	T
01	0.416	-0.451	-0.107	-0.054
02	0.08	-1.593	0.943	-1.923
03	-0.731	-3.755	0.917	-0.007
04	-0.665	-4.957	1.241	-3.947
05	-4.957	-4.499	1.377	-3.947
06	-4.185	-4.499	1.375	-3.947
07	-2.252	1.295	-4.957	-1.443
08	-3.755	-3.755	1.369	-3.755
09	-3.455	-3.755	1.127	-0.153
10	-0.484	-3.755	1.185	-2.421
11	-1.345	-2.81	1.267	-2.042
12	-1.792	1.247	-3.038	-1.185
13	-1.409	0.792	-0.948	0.149
14	-0.089	-1.226	-0.028	0.598

Standard thresholds

P-value	Threshold
0.001	2.19451
0.0005	3.51691
0.0001	6.261315