SP1.H12INVITRO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	SP1.H12INVITRO.0.P.B
Gene (human)	SP1 (GeneCards)
Gene synonyms (human)	TSFP1
Gene (mouse)	Sp1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	14
Consensus	nRKGGGCGGGGCYd
GC content	79.23%
Information content (bits; total / per base)	16.989 / 1.214
Data sources	ChIP-Seq
Aligned words	985

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	14 (91)	0.875	0.968	0.763	0.923	0.924	0.986	4.153	5.531	69.796	205.796
Mouse	10 (52)	0.897	0.958	0.815	0.905	0.896	0.962	4.032	4.552	70.39	172.509

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.995	0.992	0.948	0.935	0.745	0.781
Overall, 3 experiments	best	0.997	0.994	0.974	0.97	0.766	0.807
Methyl HT-SELEX, 1 experiments	median	0.995	0.992	0.9	0.905	0.679	0.737
Methyl HT-SELEX, 1 experiments	best	0.995	0.992	0.9	0.905	0.679	0.737
Non-Methyl HT-SELEX, 2 experiments	median	0.991	0.984	0.961	0.952	0.756	0.794
Non-Methyl HT-SELEX, 2 experiments	best	0.997	0.994	0.974	0.97	0.766	0.807

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	1.262	0.565	0.025	0.015

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Sp1-like {2.3.1.1} (TFClass)
TFClass ID	TFClass: 2.3.1.1.1
HGNC	HGNC:11205
MGI	MGI:98372
EntrezGene (human)	GeneID:6667 (SSTAR profile)
EntrezGene (mouse)	GeneID:20683 (SSTAR profile)
UniProt ID (human)	SP1_HUMAN
UniProt ID (mouse)	SP1_MOUSE
UniProt AC (human)	P08047 (TFClass)
UniProt AC (mouse)	O89090 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	14 human, 10 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	SP1.H12INVITRO.0.P.B.pcm
PWM	SP1.H12INVITRO.0.P.B.pwm
PFM	SP1.H12INVITRO.0.P.B.pfm
Alignment	SP1.H12INVITRO.0.P.B.words.tsv
Threshold to P-value map	SP1.H12INVITRO.0.P.B.thr
Motif in other formats
JASPAR format	SP1.H12INVITRO.0.P.B_jaspar_format.txt
MEME format	SP1.H12INVITRO.0.P.B_meme_format.meme
Transfac format	SP1.H12INVITRO.0.P.B_transfac_format.txt
Homer format	SP1.H12INVITRO.0.P.B_homer_format_0.001.txt SP1.H12INVITRO.0.P.B_homer_format_0.0005.txt SP1.H12INVITRO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	348.0	164.0	252.0	221.0
02	239.0	70.0	648.0	28.0
03	94.0	2.0	640.0	249.0
04	98.0	0.0	887.0	0.0
05	3.0	0.0	980.0	2.0
06	0.0	0.0	984.0	1.0
07	13.0	944.0	1.0	27.0
08	1.0	1.0	982.0	1.0
09	3.0	2.0	776.0	204.0
10	143.0	1.0	832.0	9.0
11	37.0	6.0	920.0	22.0
12	24.0	888.0	6.0	67.0
13	47.0	584.0	72.0	282.0
14	222.0	59.0	225.0	479.0

PFM

	A	C	G	T
01	0.353	0.166	0.256	0.224
02	0.243	0.071	0.658	0.028
03	0.095	0.002	0.65	0.253
04	0.099	0.0	0.901	0.0
05	0.003	0.0	0.995	0.002
06	0.0	0.0	0.999	0.001
07	0.013	0.958	0.001	0.027
08	0.001	0.001	0.997	0.001
09	0.003	0.002	0.788	0.207
10	0.145	0.001	0.845	0.009
11	0.038	0.006	0.934	0.022
12	0.024	0.902	0.006	0.068
13	0.048	0.593	0.073	0.286
14	0.225	0.06	0.228	0.486

PWM

	A	C	G	T
01	0.344	-0.403	0.023	-0.107
02	-0.03	-1.241	0.963	-2.121
03	-0.952	-4.199	0.951	0.011
04	-0.911	-4.969	1.276	-4.969
05	-3.961	-4.969	1.376	-4.199
06	-4.969	-4.969	1.38	-4.512
07	-2.824	1.339	-4.512	-2.156
08	-4.512	-4.512	1.378	-4.512
09	-3.961	-4.199	1.143	-0.187
10	-0.538	-4.512	1.213	-3.141
11	-1.857	-3.469	1.313	-2.347
12	-2.266	1.278	-3.469	-1.283
13	-1.627	0.86	-1.213	0.135
14	-0.103	-1.407	-0.09	0.662

Standard thresholds

P-value	Threshold
0.001	1.21781
0.0005	2.67306
0.0001	5.70896