MotifSP1.H12CORE.2.P.B
Gene (human)SP1
(GeneCards)
Gene synonyms (human)TSFP1
Gene (mouse)Sp1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype2
Quality
B
Motif length21
ConsensusnRKGGGCGGGGCbnvvvvvvv
GC content75.02%
Information content (bits; total / per base)16.626 / 0.792
Data sourcesChIP-Seq
Aligned words978

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 14 (91) 0.869 0.969 0.726 0.929 0.937 0.993 4.742 6.766 61.347 195.268
Mouse 10 (52) 0.885 0.948 0.804 0.888 0.897 0.962 4.304 4.851 56.406 136.824

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 3 experiments median 0.966 0.948 0.804 0.812 0.621 0.674
best 0.984 0.974 0.938 0.925 0.736 0.772
Methyl HT-SELEX, 1 experiments median 0.966 0.948 0.804 0.812 0.621 0.674
best 0.966 0.948 0.804 0.812 0.621 0.674
Non-Methyl HT-SELEX, 2 experiments median 0.951 0.931 0.829 0.83 0.658 0.7
best 0.984 0.974 0.938 0.925 0.736 0.772

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 1.283 0.636 0.02 0.013
TF superclassZinc-coordinating DNA-binding domains {2} (TFClass)
TF classC2H2 zinc finger factors {2.3} (TFClass)
TF familyThree-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamilySp1-like {2.3.1.1} (TFClass)
TFClass IDTFClass: 2.3.1.1.1
HGNCHGNC:11205
MGIMGI:98372
EntrezGene (human)GeneID:6667
(SSTAR profile)
EntrezGene (mouse)GeneID:20683
(SSTAR profile)
UniProt ID (human)SP1_HUMAN
UniProt ID (mouse)SP1_MOUSE
UniProt AC (human)P08047
(TFClass)
UniProt AC (mouse)O89090
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 14 human, 10 mouse
HT-SELEX 2
Methyl-HT-SELEX 1
PCM
ACGT
01360.0165.0244.0209.0
02258.069.0601.050.0
03102.04.0649.0223.0
04133.01.0840.04.0
053.02.0970.03.0
063.03.0972.00.0
0756.0862.01.059.0
0811.00.0960.07.0
093.02.0790.0183.0
10142.04.0815.017.0
1172.027.0838.041.0
1246.0836.020.076.0
1362.0472.0145.0299.0
14251.0112.0251.0364.0
15184.0221.0465.0108.0
16212.0200.0467.099.0
17203.0198.0461.0116.0
18147.0229.0487.0115.0
19194.0168.0468.0148.0
20176.0186.0486.0130.0
21171.0203.0513.091.0
PFM
ACGT
010.3680.1690.2490.214
020.2640.0710.6150.051
030.1040.0040.6640.228
040.1360.0010.8590.004
050.0030.0020.9920.003
060.0030.0030.9940.0
070.0570.8810.0010.06
080.0110.00.9820.007
090.0030.0020.8080.187
100.1450.0040.8330.017
110.0740.0280.8570.042
120.0470.8550.020.078
130.0630.4830.1480.306
140.2570.1150.2570.372
150.1880.2260.4750.11
160.2170.2040.4780.101
170.2080.2020.4710.119
180.150.2340.4980.118
190.1980.1720.4790.151
200.180.190.4970.133
210.1750.2080.5250.093
PWM
ACGT
010.385-0.39-0.002-0.156
020.053-1.2470.895-1.56
03-0.865-3.7620.972-0.091
04-0.603-4.5051.229-3.762
05-3.954-4.1921.373-3.954
06-3.954-3.9541.375-4.963
07-1.4511.255-4.505-1.4
08-2.963-4.9631.362-3.34
09-3.954-4.1921.168-0.287
10-0.538-3.7621.199-2.577
11-1.206-2.1491.227-1.752
12-1.6411.224-2.428-1.153
13-1.3520.654-0.5180.2
140.026-0.7720.0260.396
15-0.282-0.10.64-0.808
16-0.142-0.1990.644-0.894
17-0.185-0.2090.631-0.738
18-0.504-0.0650.686-0.746
19-0.23-0.3720.646-0.497
20-0.326-0.2710.684-0.626
21-0.355-0.1850.737-0.977
Standard thresholds
P-value Threshold
0.001 2.10391
0.0005 3.40661
0.0001 6.11391