MotifSOX2.H12INVIVO.1.P.B
Gene (human)SOX2
(GeneCards)
Gene synonyms (human)
Gene (mouse)Sox2
Gene synonyms (mouse)Sox-2
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length17
ConsensusbSYWTTGThhTKYhdWh
GC content37.14%
Information content (bits; total / per base)12.706 / 0.747
Data sourcesChIP-Seq
Aligned words1002

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 38 (216) 0.696 0.911 0.545 0.86 0.756 0.934 2.259 4.897 57.523 315.538
Mouse 116 (745) 0.807 0.948 0.729 0.923 0.833 0.958 3.076 5.639 101.959 626.523

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Non-Methyl HT-SELEX, 5 experiments median 0.547 0.528 0.534 0.522 0.521 0.516
best 0.568 0.54 0.55 0.531 0.535 0.523
TF superclassOther all-alpha-helical DNA-binding domains {4} (TFClass)
TF classHigh-mobility group (HMG) domain factors {4.1} (TFClass)
TF familySOX-related {4.1.1} (TFClass)
TF subfamilyGroup B {4.1.1.2} (TFClass)
TFClass IDTFClass: 4.1.1.2.2
HGNCHGNC:11195
MGIMGI:98364
EntrezGene (human)GeneID:6657
(SSTAR profile)
EntrezGene (mouse)GeneID:20674
(SSTAR profile)
UniProt ID (human)SOX2_HUMAN
UniProt ID (mouse)SOX2_MOUSE
UniProt AC (human)P48431
(TFClass)
UniProt AC (mouse)P48432
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 38 human, 116 mouse
HT-SELEX 5
Methyl-HT-SELEX 0
PCM
ACGT
01100.0243.0281.0378.0
0235.0636.0166.0165.0
0324.0632.026.0320.0
04524.06.04.0468.0
052.02.012.0986.0
0612.01.05.0984.0
0739.0138.0803.022.0
08136.03.04.0859.0
09124.0258.0120.0500.0
10560.0238.070.0134.0
1157.079.042.0824.0
1250.095.0694.0163.0
1366.0604.0147.0185.0
14558.0124.068.0252.0
15543.0101.0190.0168.0
16650.0131.086.0135.0
17210.0161.0157.0474.0
PFM
ACGT
010.10.2430.280.377
020.0350.6350.1660.165
030.0240.6310.0260.319
040.5230.0060.0040.467
050.0020.0020.0120.984
060.0120.0010.0050.982
070.0390.1380.8010.022
080.1360.0030.0040.857
090.1240.2570.120.499
100.5590.2380.070.134
110.0570.0790.0420.822
120.050.0950.6930.163
130.0660.6030.1470.185
140.5570.1240.0680.251
150.5420.1010.190.168
160.6490.1310.0860.135
170.210.1610.1570.473
PWM
ACGT
01-0.908-0.030.1140.409
02-1.9270.928-0.408-0.414
03-2.2830.921-2.2080.243
040.734-3.486-3.7850.622
05-4.215-4.215-2.9111.365
06-2.911-4.527-3.6241.363
07-1.823-0.5911.16-2.364
08-0.605-3.977-3.7851.227
09-0.6960.029-0.7290.688
100.801-0.051-1.257-0.62
11-1.457-1.139-1.7521.186
12-1.584-0.9581.015-0.426
13-1.3150.876-0.528-0.301
140.797-0.696-1.2860.006
150.77-0.898-0.274-0.396
160.949-0.642-1.056-0.612
17-0.175-0.438-0.4630.635
Standard thresholds
P-value Threshold
0.001 4.01841
0.0005 5.02746
0.0001 7.08256