MotifSOX2.H12INVIVO.0.P.B
Gene (human)SOX2
(GeneCards)
Gene synonyms (human)
Gene (mouse)Sox2
Gene synonyms (mouse)Sox-2
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
B
Motif length12
ConsensusbSYWTTGTYhYb
GC content39.74%
Information content (bits; total / per base)11.628 / 0.969
Data sourcesChIP-Seq
Aligned words1007

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 38 (216) 0.794 0.863 0.656 0.758 0.808 0.868 2.437 2.952 103.321 214.027
Mouse 116 (745) 0.818 0.89 0.682 0.832 0.834 0.908 2.643 3.519 104.959 271.585

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Non-Methyl HT-SELEX, 5 experiments median 0.565 0.54 0.545 0.529 0.529 0.521
best 0.578 0.546 0.557 0.536 0.54 0.527
TF superclassOther all-alpha-helical DNA-binding domains {4} (TFClass)
TF classHigh-mobility group (HMG) domain factors {4.1} (TFClass)
TF familySOX-related {4.1.1} (TFClass)
TF subfamilyGroup B {4.1.1.2} (TFClass)
TFClass IDTFClass: 4.1.1.2.2
HGNCHGNC:11195
MGIMGI:98364
EntrezGene (human)GeneID:6657
(SSTAR profile)
EntrezGene (mouse)GeneID:20674
(SSTAR profile)
UniProt ID (human)SOX2_HUMAN
UniProt ID (mouse)SOX2_MOUSE
UniProt AC (human)P48431
(TFClass)
UniProt AC (mouse)P48432
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 38 human, 116 mouse
HT-SELEX 5
Methyl-HT-SELEX 0
PCM
ACGT
0171.0250.0313.0373.0
0213.0703.0147.0144.0
0311.0618.013.0365.0
04497.09.01.0500.0
051.04.04.0998.0
062.00.02.01003.0
0717.044.0941.05.0
0814.01.02.0990.0
0971.0296.087.0553.0
10386.0365.084.0172.0
1193.0145.063.0706.0
12120.0171.0539.0177.0
PFM
ACGT
010.0710.2480.3110.37
020.0130.6980.1460.143
030.0110.6140.0130.362
040.4940.0090.0010.497
050.0010.0040.0040.991
060.0020.00.0020.996
070.0170.0440.9340.005
080.0140.0010.0020.983
090.0710.2940.0860.549
100.3830.3620.0830.171
110.0920.1440.0630.701
120.1190.170.5350.176
PWM
ACGT
01-1.249-0.0070.2160.391
02-2.8451.023-0.533-0.554
03-2.9910.894-2.8450.369
040.677-3.162-4.5310.683
05-4.531-3.79-3.791.372
06-4.219-4.988-4.2191.377
07-2.605-1.7131.313-3.629
08-2.78-4.531-4.2191.364
09-1.2490.161-1.050.783
100.4250.369-1.084-0.378
11-0.984-0.547-1.3651.027
12-0.733-0.3840.758-0.349
Standard thresholds
P-value Threshold
0.001 4.15528
0.0005 5.29547
0.0001 7.489715